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Biology and Biochemistry

D-Index
91
Citations
27124
World Ranking
2341
National Ranking
158

Overview

David Pearce is a researcher affiliated with Northumbria University in the United Kingdom. Their work spans multiple disciplines within the broader fields of Medicine and Biochemistry, Genetics and Molecular Biology. Most of their research focuses on genetics, physiology, molecular biology, orthopedics and sports medicine, and cell biology as specialized subfields.

The scientist's research topics cover a range of areas related to rare diseases and molecular biology, including:

  • Genomics and Rare Diseases
  • Lysosomal Storage Disorders Research
  • Mesenchymal Stem Cell Research
  • Cellular Transport and Secretion
  • Sports Injuries and Prevention
  • Cancer Genomics and Diagnostics
  • CRISPR and Genetic Engineering

David Pearce has published extensively in various scientific journals. Frequent venues for their publications include:

  • Scientific Reports
  • Rare Disease and Orphan Drugs Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Orphanet Journal of Rare Diseases
  • Cells

Some of their recent papers are:

  • The IDeaS initiative: pilot study to assess the impact of rare diseases on patients and healthcare systems, 2021, Orphanet Journal of Rare Diseases
  • Recommendations from the IRDiRC Working Group on methodologies to assess the impact of diagnoses and therapies on rare disease patients, 2022, Orphanet Journal of Rare Diseases
  • Methodological Flaws in Meta-Analyses of Clinical Studies on the Management of Knee Osteoarthritis with Stem Cells: A Systematic Review, 2022, Cells
  • Research on rare diseases: ten years of progress and challenges at IRDiRC, 2022, Nature Reviews Drug Discovery
  • Targeting shared molecular etiologies to accelerate drug development for rare diseases, 2023, EMBO Molecular Medicine

Collaboration has been a significant aspect of Pearce's research, with frequent co-authors including:

  • Christopher Alt
  • Nicola Maffulli
  • Eckhard Alt
  • Christoph Schmitz
  • Chun-Hung Chan

Best Publications

  • Epithelial sodium channel regulated by aldosterone-induced protein sgk.

    Sei-yu Chen;Aditi Bhargava;Luca Mastroberardino;Onno C. Meijer

  • Phosphorylation of Nedd4‐2 by Sgk1 regulates epithelial Na+ channel cell surface expression

    Christophe Debonneville;Christophe Debonneville;Sandra Y. Flores;Sandra Y. Flores;Elena Kamynina;Pamela J. Plant

  • A multi-decade record of high-quality fCO2 data in version 3 of the Surface Ocean CO2 Atlas (SOCAT)

    Dorothee C. E. Bakker;Benjamin Pfeil;Benjamin Pfeil;Camilla S. Landa;Camilla S. Landa;Nicolas Metzl

  • Mineralocorticoid and glucocorticoid receptor activities distinguished by nonreceptor factors at a composite response element

    David Pearce;Keith R. Yamamoto

  • Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK.

    Johannes Loffing;Marija Zecevic;Eric Féraille;Brigitte Kaissling

  • Subcellular localization of mineralocorticoid receptors in living cells: Effects of receptor agonists and antagonists

    Géza Fejes-Tóth;David Pearce;Anikó Náray-Fejes-Tóth

  • Reelin signaling is impaired in autism.

    S. Hossein Fatemi;Anne V. Snow;Joel M. Stary;Mohsen Araghi-Niknam

  • A Common Motif within the Negative Regulatory Regions of Multiple Factors Inhibits Their Transcriptional Synergy

    Jorge A. Iñiguez-Lluhí;David Pearce

  • Patterns of bacterial diversity across a range of Antarctic terrestrial habitats.

    Etienne Yergeau;Kevin K. Newsham;David A. Pearce;George A. Kowalchuk

  • Multiple corticosteroid receptors in a teleost fish: distinct sequences, expression patterns, and transcriptional activities.

    Anna K. Greenwood;Paul C. Butler;Richard B. White;Ulrike DeMarco

  • The Discovery of New Deep-Sea Hydrothermal Vent Communities in the Southern Ocean and Implications for Biogeography

    Alex D. Rogers;Paul A. Tyler;Douglas P. Connelly;Jonathan T. Copley

  • Collecting Duct Principal Cell Transport Processes and Their Regulation

    David Pearce;Rama Soundararajan;Christiane Trimpert;Ossama B. Kashlan

  • Steroid receptor heterodimerization demonstrated in vitro and in vivo.

    Weihong Liu;Jian Wang;Nicholas K. Sauter;David Pearce

  • Androgen and Glucocorticoid Receptor Heterodimer Formation A POSSIBLE MECHANISM FOR MUTUAL INHIBITION OF TRANSCRIPTIONAL ACTIVITY

    Sei-yu Chen;Jian Wang;Gui-qiu Yu;Weihong Liu

  • You say lipofuscin, we say ceroid: defining autofluorescent storage material.

    Sabrina S Seehafer;David A Pearce

  • SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport.

    Jian Wang;Pascal Barbry;Anita C. Maiyar;David J. Rozansky

  • Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.

    Kevin T Jones;Elisabeth R Greer;David Pearce;Kaveh Ashrafi

  • Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3.

    Vivek Bhalla;Dorothée Daidié;Hongyan Li;Alan C. Pao

  • Nonsense-mediated decay in genetic disease: friend or foe?

    Jake N. Miller;David A. Pearce

  • SGK1 regulation of epithelial sodium transport.

    David Pearce

Frequent Co-Authors

Peter Convey
Peter Convey British Antarctic Survey
Jonathan D. Cooper
Jonathan D. Cooper Washington University in St. Louis
Fred Sherman
Fred Sherman University of Rochester
Florian Lang
Florian Lang University of Tübingen
Andy Hodson
Andy Hodson University Centre in Svalbard
Martin J. Siegert
Martin J. Siegert University of Exeter
Martyn Tranter
Martyn Tranter Aarhus University
Charles S. Cockell
Charles S. Cockell University of Edinburgh
Kok-Gan Chan
Kok-Gan Chan University of Malaya
Dominic A. Hodgson
Dominic A. Hodgson British Antarctic Survey

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