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Molecular Biology

D-Index
67
Citations
22703
World Ranking
1552
National Ranking
785

Overview

Deborah K. Morrison is affiliated with the National Institutes of Health in the United States and has a research focus centered on biochemistry, genetics, and molecular biology. The primary subfield of their work is molecular biology, with additional contributions to oncology, computational theory and mathematics, pharmacology, and cell biology.

The scientist's main research topics include:

  • Melanoma and MAPK Pathways
  • Protein Kinase Regulation and GTPase Signaling
  • 14-3-3 protein interactions
  • Protein Tyrosine Phosphatases
  • Computational Drug Discovery Methods
  • Cancer-related Molecular Pathways
  • Microbial Natural Products and Biosynthesis

Recent publications by Deborah K. Morrison reflect their focus on molecular signaling mechanisms and cancer-related pathways. Notable papers include:

  • "Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding," 2022, published in Nature Communications
  • "A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation," 2022, published in Cancer Discovery
  • "Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies," 2020, published in American Journal of Medical Genetics Part A
  • "TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin," 2021, published in Cancer Discovery
  • "Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation," 2022, published in Nature Communications

Deborah K. Morrison frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, The FASEB Journal, Molecular Cancer Research, and Nature Communications.

The scientist has collaborated extensively with coauthors including Daniel A. Ritt, Elizabeth M. Terrell, David Durrant, Andrew G. Stephen, and Russell Spencer-Smith. These collaborations have contributed to a significant body of work exploring molecular biology and cancer pathways.

Best Publications

  • The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

    Thomas F Franke;Sung-Il Yang;Tung O Chan;Ketaki Datta

  • Comparative Genomics of the Eukaryotes

    Gerald M. Rubin;Mark D. Yandell;Jennifer R. Wortman;George L. Gabor

  • Regulation of MAP kinase signaling modules by scaffold proteins in mammals.

    Deborah K. Morrison;Roger J. Davis

  • MAP Kinase Pathways

    Deborah K. Morrison

  • The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

    Deborah K. Morrison

  • Regulation of Raf-1 by Direct Feedback Phosphorylation

    Michele K. Dougherty;Jürgen Müller;Daniel A. Ritt;Ming Zhou

  • Unlocking the code of 14-3-3

    Michele K. Dougherty;Deborah K. Morrison

  • PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex

    David R. Kaplan;Deborah K. Morrison;Gail Wong;Frank McCormick

  • Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

    Deborah K. Morrison;David R. Kaplan;Jaime A. Escobedo;Ulf R. Rapp

  • Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.

    J R Fabian;I O Daar;D K Morrison

  • Identification of the major phosphorylation sites of the Raf-1 kinase.

    D K Morrison;G Heidecker;U R Rapp;T D Copeland

  • Raf functions downstream of Ras1 in the Sevenless signal transduction pathway.

    Barry Dickson;Frank Sprenger;Frank Sprenger;Deborah Morrison;Ernst Hafen

  • Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites.

    Stéphane Ory;Ming Zhou;Thomas P Conrads;Timothy D Veenstra

  • C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1.

    Jürgen Müller;Stéphane Ory;Terry Copeland;Helen Piwnica-Worms

  • KSR modulates signal propagation within the MAPK cascade.

    M Therrien;N R Michaud;G M Rubin;D K Morrison

  • The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

    Lyuba Varticovski;Brian Druker;Deborah Morrison;Deborah Morrison;Lewis Cantley

  • Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate.

    Giulio Draetta;Helen Piwnica-Worms;Deborah Morrison;Brian Druker

  • Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling

    Daniel A. Ritt;Daniel M. Monson;Suzanne I. Specht;Deborah K. Morrison

  • 14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner.

    N R Michaud;J R Fabian;K D Mathes;D K Morrison

  • 14-3-3 Proteins: Diverse functions in cell proliferation and cancer progression

    Alyson K. Freeman;Deborah K. Morrison

Frequent Co-Authors

Terry D. Copeland
Terry D. Copeland National Institutes of Health
Ming Zhou
Ming Zhou Science Applications International Corporation (United States)
Gerald M. Rubin
Gerald M. Rubin Howard Hughes Medical Institute
Timothy D. Veenstra
Timothy D. Veenstra Lake Erie College of Osteopathic Medicine
Peter F. Johnson
Peter F. Johnson National Institutes of Health
Thomas P. Conrads
Thomas P. Conrads University of Pittsburgh
Michele K. Dougherty
Michele K. Dougherty Imperial College London
Mitsuhiko Ikura
Mitsuhiko Ikura Princess Margaret Cancer Centre
Norbert Perrimon
Norbert Perrimon Harvard University
Benjamin E. Turk
Benjamin E. Turk Yale University

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