World's Best Scientists 2026 revealed!
Award Badge
Genetics and Molecular Biology
Ireland
2024

D-Index & Metrics

Molecular Biology

D-Index
102
Citations
43144
World Ranking
493
National Ranking
1

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Ireland Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Ireland Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Ireland Leader Award
  • 2016 - Member of the Royal Irish Academy
  • 2006 - Fellow of the Royal Society of Edinburgh

Overview

Walter Kolch is affiliated with University College Dublin in Ireland and specializes in research within the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work has a strong focus on Molecular Biology, Oncology, Immunology, Cell Biology, and Cancer Research as subfields of study.

The scientist's research covers several main topics, including:

  • Melanoma and MAPK Pathways
  • Computational Drug Discovery Methods
  • Protein Kinase Regulation and GTPase Signaling
  • Single-cell and spatial transcriptomics
  • Cancer Genomics and Diagnostics
  • Cancer Immunotherapy and Biomarkers
  • Neuroblastoma Research and Treatments

Walter Kolch has contributed to numerous publications. Notable recent papers include:

  • "Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity," 2020, published in International Journal of Molecular Sciences
  • "Control of cell state transitions," 2022, published in Nature
  • "Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D," 2020, published in Nature Communications
  • "Dynamic regulation of RAS and RAS signaling," 2023, published in Biochemical Journal
  • "Precision Therapy in RAS Mutant Colorectal Cancer," 2020, published in Gastroenterology

Frequent co-authors collaborating with Walter Kolch include Kieran Wynne, Donal J. Brennan, Vadim Zhernovkov, Donagh Egan, and Aleksandar Krstić. These collaborations reflect ongoing partnerships within the research community.

Research outputs often appear in the following publication venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancers
  • Journal of Personalized Medicine
  • Biomolecules
  • Scientific Reports

Walter Kolch has received recognition from academic institutions, being awarded the status of Fellow of the Royal Society of Edinburgh in 2006 and becoming a Member of the Royal Irish Academy in 2016. These distinctions highlight their standing within the scientific community.

Best Publications

  • MAP kinase signalling pathways in cancer.

    A. S. Dhillon;Suzanne Hagan;O. Rath;W. Kolch

  • Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.

    Walter Kolch

  • Protein kinase C alpha activates RAF-1 by direct phosphorylation

    Walter Kolch;Gisela Heidecker;Georg Kochs;Richard Hummel

  • Coordinating ERK/MAPK signalling through scaffolds and inhibitors

    Walter Kolch

  • Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

    Kam Yeung;Thomas Seitz;Shengfeng Li;Petra Janosch

  • Signalling ballet in space and time

    Boris N. Kholodenko;John F. Hancock;Walter Kolch

  • Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

    H Mischak;J A Goodnight;W Kolch;G Martiny-Baron

  • Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

    A Kieser;H A Weich;G Brandner;D Marmé

  • Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

    Walter Kolch;Gisela Heidecker;Patricia Lloyd;Ulf R. Rapp

  • Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease

    David M. Good;Petra Zürbig;Àngel Argilés;Hartwig W. Bauer

  • Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity.

    Shannon Lee;Jens Rauch;Walter Kolch

  • The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

    Christian Johannes Gloeckner;Norbert Kinkl;Annette Schumacher;Ralf J. Braun

  • Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

    Richard J. Orton;Oliver E. Sturm;Vladislav Vyshemirsky;Muffy Calder

  • Regulation and role of Raf-1/B-Raf heterodimerization.

    Linda K. Rushworth;Alison D. Hindley;Eric O'Neill;Walter Kolch

  • Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein

    Kam Yeung;Petra Janosch;Brian McFerran;David W. Rose

  • Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells.

    Shih Chu Kao;Rama K. Jaiswal;Walter Kolch;Gary E. Landreth

  • Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation

    Kam C. Yeung;David W. Rose;Amardeep S. Dhillon;Diane Yaros

  • RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein.

    David Matallanas;David Romano;Karen Yee;Katrin Meissl

  • Raf Family Kinases: Old Dogs Have Learned New Tricks

    David Matallanas;Marc Birtwistle;David Romano;Armin Zebisch

  • Epstein–Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade

    Arnd Kieser;Ellen Kilger;Olivier Gires;Marius Ueffing

Frequent Co-Authors

Boris N. Kholodenko
Boris N. Kholodenko University College Dublin
Harald Mischak
Harald Mischak University of Glasgow
Alex von Kriegsheim
Alex von Kriegsheim University of Edinburgh
Mark Girolami
Mark Girolami University of Cambridge
Ulf R. Rapp
Ulf R. Rapp Max Planck Society
Kwang-Hyun Cho
Kwang-Hyun Cho Korea Advanced Institute of Science and Technology
David Gilbert
David Gilbert Brunel University London
John M. Sedivy
John M. Sedivy Brown University
Olaf Wolkenhauer
Olaf Wolkenhauer University of Rostock
Fahd Al-Mulla
Fahd Al-Mulla Kuwait University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring a degree in Molecular Biology opens doors to several related fields, many of which offer flexible online study options. For those interested in healthcare and communication sciences, accredited speech pathology programs are becoming more accessible, allowing students to pursue certification remotely while meeting ASHA standards.

If you come from a non-science background but want to shift into speech-language pathology, specialized transition to SLP master’s for non-CSD majors pathways can help you prepare for graduate programs in this high-growth area.

The healthcare industry also offers accelerated educational tracks. Individuals with a non-nursing background can enroll in accelerated bsn programs for non nurses, earning a nursing degree online in less time than traditional routes.

Career opportunities following these pathways are promising. For instance, those interested in advanced nursing can investigate how much does a psychiatric nurse practitioner make to understand salary trends and long-term career growth. Online degrees in related health sciences continue to evolve, making it easier for students to pursue new and rewarding professional directions.

Best Scientists Citing Walter Kolch

Trending Scientists

Recently Published Articles