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Molecular Biology

D-Index
88
Citations
40437
World Ranking
774
National Ranking
410

Overview

John M. Sedivy is affiliated with Brown University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine.

Their main subfields of study include molecular biology, physiology, plant science, immunology, and cardiology and cardiovascular medicine. Sedivy's work frequently addresses topics such as telomeres, telomerase, and senescence; chromosomal and genetic variations; CRISPR and genetic engineering; genetics, aging, and longevity in model organisms; cardiac fibrosis and remodeling; epigenetics and DNA methylation; and advanced biosensing and bioanalysis techniques.

The scientist has published extensively, with notable papers including:

  • Loss of epigenetic information as a cause of mammalian aging, 2023, Cell
  • The role of retrotransposable elements in ageing and age-associated diseases, 2021, Nature
  • Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention, 2021, Signal Transduction and Targeted Therapy
  • CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels, 2020, Nature Metabolism
  • Guidelines for minimal information on cellular senescence experimentation in vivo, 2024, Cell

Frequently publishing in venues such as bioRxiv (Cold Spring Harbor Laboratory), The FASEB Journal, Cell, Cancer Research, and Signal Transduction and Targeted Therapy, Sedivy maintains a consistent presence in high-impact journals.

Collaborations feature prominently in their work. Notable frequent coauthors include Jill A. Kreiling, Vadim N. Gladyshev, Jef D. Boeke, Nicola Neretti, and Brett Baggett.

Best Publications

  • Requirement for p53 and p21 to Sustain G2 Arrest After DNA Damage

    Fred Bunz;A. Dutriaux;C. Lengauer;T. Waldman

  • Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging

    G. C. Kujoth;A. Hiona;T. D. Pugh;S. Someya

  • Cellular Senescence: Defining a Path Forward

    Vassilis Gorgoulis;Peter D. Adams;Andrea Alimonti;Dorothy C. Bennett

  • Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

    Utz Herbig;Wendy A Jobling;Benjamin P.C Chen;David J Chen

  • Cellular senescence in aging primates.

    Utz Herbig;Mark Ferreira;Mark Ferreira;Laura Condel;Laura Condel;Dee Carey;Dee Carey

  • Bypass of Senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

    Jeremy P. Brown;Wenyi Wei;John M. Sedivy

  • Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP

    Kam Yeung;Thomas Seitz;Shengfeng Li;Petra Janosch

  • L1 drives IFN in senescent cells and promotes age-associated inflammation

    Marco De Cecco;Takahiro Ito;Anna P. Petrashen;Amy E. Elias

  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

    Christopher M. Counter;William C. Hahn;Wenyi Wei;Stephanie Dickinson Caddle

  • Accumulation of senescent cells in mitotic tissue of aging primates.

    Jessie C. Jeyapalan;Mark Ferreira;John M. Sedivy;Utz Herbig

  • Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

    Tammy Bowman;Martin A. Broome;Dominic Sinibaldi;Walker Wharton

  • Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination

    Maria K. Mateyak;Alvaro J. Obaya;Susumu Adachi;John M. Sedivy

  • Interventions to Slow Aging in Humans: Are We Ready?

    Valter D. Longo;Adam Antebi;Andrzej Bartke;Nir Barzilai

  • Identification of CDK4 as a target of c-MYC.

    Heiko Hermeking;Carlo Rago;Marino Schuhmacher;Qing Li

  • Regulation of cyclin-Cdk activity in mammalian cells.

    A.J. Obaya;J.M. Sedivy

  • Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein

    Kam Yeung;Petra Janosch;Brian McFerran;David W. Rose

  • Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation

    Kam C. Yeung;David W. Rose;Amardeep S. Dhillon;Diane Yaros

  • Cellular senescence and organismal aging.

    Jessie C. Jeyapalan;John M. Sedivy

  • c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points.

    Maria K. Mateyak;Alvaro J. Obaya;John M. Sedivy

  • Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

    Marco De Cecco;Steven W. Criscione;Edward J. Peckham;Sara Hillenmeyer

Frequent Co-Authors

Wenyi Wei
Wenyi Wei Beth Israel Deaconess Medical Center
Adam Antebi
Adam Antebi Max Planck Society
Claudio Franceschi
Claudio Franceschi University of Bologna
Walter Kolch
Walter Kolch University College Dublin
Peter D. Adams
Peter D. Adams Sanford Burnham Prebys Medical Discovery Institute
Stephen L. Helfand
Stephen L. Helfand Brown University
Linda Z. Penn
Linda Z. Penn University of Toronto
Harald Mischak
Harald Mischak University of Glasgow
David A. Sinclair
David A. Sinclair Harvard University
Ana Maria Cuervo
Ana Maria Cuervo Albert Einstein College of Medicine

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