World's Best Scientists 2026 revealed!
Stephen L. Helfand

Stephen L. Helfand

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
15449
World Ranking
12382
National Ranking
5300

Stephen L. Helfand publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Stephen L. Helfand sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 124 publications — 14th percentile

14% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Stephen L. Helfand D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Stephen L. Helfand sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 59 D-Index — 38th percentile

38% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Stephen L. Helfand is affiliated with Brown University in the United States. Their research spans fields including Medicine and Biochemistry, Genetics and Molecular Biology. Within these, Helfand's work focuses on subfields such as Physiology, Aging, Molecular Biology, Geriatrics and Gerontology, and Endocrine and Autonomic Systems.

The main topics of Helfand's research include Genetics, Aging, and Longevity in Model Organisms; Sirtuins and Resveratrol in Medicine; Dietary Effects on Health; Circadian Rhythm and Melatonin; Chromosomal and Genetic Variations; CRISPR and Genetic Engineering; and Advanced Biosensing and Bioanalysis Techniques.

Recent papers authored or co-authored by Helfand are as follows:

  • The role of retrotransposable elements in ageing and age-associated diseases, 2021, published in Nature
  • Sirt6 regulates lifespan in Drosophila melanogaster, 2022, published in Proceedings of the National Academy of Sciences
  • A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth, 2022, published in Proceedings of the National Academy of Sciences
  • The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms, 2021, published in JCI Insight
  • Evidence that overnight fasting could extend healthy lifespan, 2021, published in Nature

Frequent co-authors in Helfand's publications include Jackson Taylor, Rafael de Cabo, Vera Gorbunova, Andrei Seluanov, and Jef D. Boeke.

Helfand's research has been published predominantly in venues such as Nature and the Proceedings of the National Academy of Sciences, with multiple publications also appearing in Innovation in Aging, JCI Insight, and The Journals of Gerontology Series A.

In 2017, Helfand was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Sirtuin activators mimic caloric restriction and delay ageing in metazoans

    Jason G. Wood;Blanka Rogina;Siva Lavu;Konrad Howitz

  • L1 drives IFN in senescent cells and promotes age-associated inflammation

    Marco De Cecco;Takahiro Ito;Anna P. Petrashen;Amy E. Elias

  • Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1.

    R C McGarry;S L Helfand;R H Quarles;J C Roder

  • Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

    Blanka Rogina;Robert A. Reenan;Steven P. Nilsen;Stephen L. Helfand

  • Segmental distribution of bithorax complex proteins during Drosophila development

    Philip A. Beachy;Stephen L. Helfand;David S. Hogness

  • Cell recognition during neuronal development.

    Corey S. Goodman;Michael J. Bastiani;Chris Q. Doe;Sascha Du Lac

  • LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

    Matthew Simon;Michael Van Meter;Julia Ablaeva;Zhonghe Ke

  • The role of retrotransposable elements in ageing and age-associated diseases

    Vera Gorbunova;Andrei Seluanov;Paolo Mita;Wilson McKerrow

  • Chemiluminescence response of human natural killer cells. I. The relationship between target cell binding, chemiluminescence, and cytolysis.

    Stephen L. Helfand;Jerome Werkmeister;John C. Roder

  • Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

    Yih-Woei C. Fridell;Adolfo Sánchez-Blanco;Brian A. Silvia;Stephen L. Helfand

  • Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia.

    Stephen L. Helfand;Gary A. Smith;Norman K. Wessells

  • Genetics of aging in the fruit fly, Drosophila melanogaster.

    Stephen L. Helfand;Blanka Rogina

  • Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila

    Jason G. Wood;Brian C. Jones;Nan Jiang;Chengyi Chang

  • Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.

    Andreas L. Birkenfeld;Hui-Young Lee;Hui-Young Lee;Fitsum Guebre-Egziabher;Fitsum Guebre-Egziabher;Tiago C. Alves;Tiago C. Alves

  • Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies

    James H. Marden;Blanka Rogina;Kristi L. Montooth;Kristi L. Montooth;Stephen L. Helfand

  • Chromatin remodeling in the aging genome of Drosophila.

    Jason G. Wood;Sara Hillenmeyer;Charles Lawrence;Chengyi Chang

  • Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span

    Johannes H. Bauer;Peter C. Poon;Heather Glatt-Deeley;John M. Abrams

  • Non-equivalence of conditioned medium and nerve growth factor for sympathetic, parasympathetic, and sensory neurons.

    Stephen L. Helfand;Richard J. Riopelle;Norman K. Wessells

  • Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction

    Tyson G. Bross;Blanka Rogina;Stephen L. Helfand

  • Neuronal specificity and growth cone guidance in grasshopper and Drosophila embryos

    Michael J. Bastiani;Chris Q. Doe;Stephen L. Helfand;Corey S. Goodman

Frequent Co-Authors

John M. Sedivy
John M. Sedivy Brown University
David A. Sinclair
David A. Sinclair Harvard University
Marc Tatar
Marc Tatar Brown University
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Jens Jordan
Jens Jordan German Aerospace Center
Gerald I. Shulman
Gerald I. Shulman Yale University
Rafael de Cabo
Rafael de Cabo National Institutes of Health
Manuel Serrano
Manuel Serrano Institució Catalana de Recerca i Estudis Avançats
Vera Gorbunova
Vera Gorbunova University of Rochester
Andrei Seluanov
Andrei Seluanov University of Rochester

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