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Stephen L. Helfand

Stephen L. Helfand

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
15449
World Ranking
12382
National Ranking
5300

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Stephen L. Helfand is affiliated with Brown University in the United States. Their research spans fields including Medicine and Biochemistry, Genetics and Molecular Biology. Within these, Helfand's work focuses on subfields such as Physiology, Aging, Molecular Biology, Geriatrics and Gerontology, and Endocrine and Autonomic Systems.

The main topics of Helfand's research include Genetics, Aging, and Longevity in Model Organisms; Sirtuins and Resveratrol in Medicine; Dietary Effects on Health; Circadian Rhythm and Melatonin; Chromosomal and Genetic Variations; CRISPR and Genetic Engineering; and Advanced Biosensing and Bioanalysis Techniques.

Recent papers authored or co-authored by Helfand are as follows:

  • The role of retrotransposable elements in ageing and age-associated diseases, 2021, published in Nature
  • Sirt6 regulates lifespan in Drosophila melanogaster, 2022, published in Proceedings of the National Academy of Sciences
  • A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth, 2022, published in Proceedings of the National Academy of Sciences
  • The longevity gene mIndy (I'm Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms, 2021, published in JCI Insight
  • Evidence that overnight fasting could extend healthy lifespan, 2021, published in Nature

Frequent co-authors in Helfand's publications include Jackson Taylor, Rafael de Cabo, Vera Gorbunova, Andrei Seluanov, and Jef D. Boeke.

Helfand's research has been published predominantly in venues such as Nature and the Proceedings of the National Academy of Sciences, with multiple publications also appearing in Innovation in Aging, JCI Insight, and The Journals of Gerontology Series A.

In 2017, Helfand was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Sirtuin activators mimic caloric restriction and delay ageing in metazoans

    Jason G. Wood;Blanka Rogina;Siva Lavu;Konrad Howitz

  • L1 drives IFN in senescent cells and promotes age-associated inflammation

    Marco De Cecco;Takahiro Ito;Anna P. Petrashen;Amy E. Elias

  • Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1.

    R C McGarry;S L Helfand;R H Quarles;J C Roder

  • Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila

    Blanka Rogina;Robert A. Reenan;Steven P. Nilsen;Stephen L. Helfand

  • Segmental distribution of bithorax complex proteins during Drosophila development

    Philip A. Beachy;Stephen L. Helfand;David S. Hogness

  • Cell recognition during neuronal development.

    Corey S. Goodman;Michael J. Bastiani;Chris Q. Doe;Sascha Du Lac

  • LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

    Matthew Simon;Michael Van Meter;Julia Ablaeva;Zhonghe Ke

  • The role of retrotransposable elements in ageing and age-associated diseases

    Vera Gorbunova;Andrei Seluanov;Paolo Mita;Wilson McKerrow

  • Chemiluminescence response of human natural killer cells. I. The relationship between target cell binding, chemiluminescence, and cytolysis.

    Stephen L. Helfand;Jerome Werkmeister;John C. Roder

  • Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.

    Yih-Woei C. Fridell;Adolfo Sánchez-Blanco;Brian A. Silvia;Stephen L. Helfand

  • Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia.

    Stephen L. Helfand;Gary A. Smith;Norman K. Wessells

  • Genetics of aging in the fruit fly, Drosophila melanogaster.

    Stephen L. Helfand;Blanka Rogina

  • Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila

    Jason G. Wood;Brian C. Jones;Nan Jiang;Chengyi Chang

  • Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.

    Andreas L. Birkenfeld;Hui-Young Lee;Hui-Young Lee;Fitsum Guebre-Egziabher;Fitsum Guebre-Egziabher;Tiago C. Alves;Tiago C. Alves

  • Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies

    James H. Marden;Blanka Rogina;Kristi L. Montooth;Kristi L. Montooth;Stephen L. Helfand

  • Chromatin remodeling in the aging genome of Drosophila.

    Jason G. Wood;Sara Hillenmeyer;Charles Lawrence;Chengyi Chang

  • Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span

    Johannes H. Bauer;Peter C. Poon;Heather Glatt-Deeley;John M. Abrams

  • Non-equivalence of conditioned medium and nerve growth factor for sympathetic, parasympathetic, and sensory neurons.

    Stephen L. Helfand;Richard J. Riopelle;Norman K. Wessells

  • Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction

    Tyson G. Bross;Blanka Rogina;Stephen L. Helfand

  • Neuronal specificity and growth cone guidance in grasshopper and Drosophila embryos

    Michael J. Bastiani;Chris Q. Doe;Stephen L. Helfand;Corey S. Goodman

Frequent Co-Authors

John M. Sedivy
John M. Sedivy Brown University
David A. Sinclair
David A. Sinclair Harvard University
Marc Tatar
Marc Tatar Brown University
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Jens Jordan
Jens Jordan German Aerospace Center
Gerald I. Shulman
Gerald I. Shulman Yale University
Rafael de Cabo
Rafael de Cabo National Institutes of Health
Manuel Serrano
Manuel Serrano Institució Catalana de Recerca i Estudis Avançats
Vera Gorbunova
Vera Gorbunova University of Rochester
Andrei Seluanov
Andrei Seluanov University of Rochester

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