World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
38351
World Ranking
3075
National Ranking
1557

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Matt Kaeberlein is affiliated with the University of Washington in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant number of publications in molecular biology, aging, physiology, genetics, and pediatrics, perinatology, and child health.

Their main topics of study include genetics, aging, and longevity in model organisms, mitochondrial function and pathology, human-animal interaction studies, fungal and yeast genetics research, diet and metabolism studies, circadian rhythm and melatonin, and birth, development, and health.

Recent scholarly contributions by Matt Kaeberlein include:

  • Biomarkers of aging for the identification and evaluation of longevity interventions (2023, Cell)
  • Taurine deficiency as a driver of aging (2023, Science)
  • Antiaging diets: Separating fact from fiction (2021, Science)
  • An open science study of ageing in companion dogs (2022, Nature)
  • Interpretable machine learning prediction of all-cause mortality (2022, Communications Medicine)

Matt Kaeberlein has collaborated frequently with several researchers, including:

  • Daniel Promislow
  • Kate E. Creevy
  • Matthew D. Dunbar
  • Audrey Ruple
  • Stephen M. Schwartz

Their publications appear predominantly in venues such as GeroScience, bioRxiv (Cold Spring Harbor Laboratory), Innovation in Aging, BioEssays, and eLife.

In 2017, Matt Kaeberlein was recognized as a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

    Shin-ichiro Imai;Christopher M. Armstrong;Matt Kaeberlein;Leonard Guarente

  • The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

    Matt Kaeberlein;Mitch McVey;Leonard Guarente

  • mTOR is a key modulator of ageing and age-related disease

    Simon C. Johnson;Peter S. Rabinovitch;Matt Kaeberlein;Matt Kaeberlein

  • Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

    Matt Kaeberlein;R. Wilson Powers;Kristan K. Steffen;Eric A. Westman

  • Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

    Su Ju Lin;Matt Kaeberlein;Alex A. Andalis;Lori A. Sturtz

  • Extension of chronological life span in yeast by decreased TOR pathway signaling

    R. Wilson Powers;Matt Kaeberlein;Seth D. Caldwell;Brian K. Kennedy

  • Substrate-specific Activation of Sirtuins by Resveratrol

    Matt Kaeberlein;Thomas McDonagh;Birgit Heltweg;Jeffrey Hixon

  • Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

    Camilla Burnett;Sara Valentini;Filipe Gomes Cabreiro;Martin Goss

  • Histone H4 lysine-16 acetylation regulates cellular lifespan

    Weiwei Dang;Kristan K. Steffen;Rocco Perry;Jean A. Dorsey

  • Replicative and Chronological Aging in Saccharomyces cerevisiae

    Valter D. Longo;Gerald S. Shadel;Matt Kaeberlein;Matt Kaeberlein;Brian Kennedy;Brian Kennedy

  • Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

    Matt Kaeberlein;Kathryn T Kirkland;Stanley Fields;Brian K Kennedy

  • mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

    Simon C. Johnson;Melana E. Yanos;Ernst Bernhard Kayser;Albert Quintana

  • Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

    Kristan K. Steffen;Vivian L. MacKay;Emily O. Kerr;Mitsuhiro Tsuchiya

  • Lessons on longevity from budding yeast

    Matt Kaeberlein;Matt Kaeberlein

  • Elimination of Replication Block Protein Fob1 Extends the Life Span of Yeast Mother Cells

    Pierre Antoine Defossez;Reeta Prusty;Matt Kaeberlein;Su Ju Lin

  • The TOR pathway comes of age.

    Monique N. Stanfel;Lara S. Shamieh;Matt Kaeberlein;Brian K. Kennedy

  • A molecular mechanism of chronological aging in yeast

    Christopher R. Burtner;Christopher J. Murakami;Brian K. Kennedy;Matt Kaeberlein

  • Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

    Alessandro Bitto;Takashi K Ito;Victor V Pineda;Nicolas J LeTexier

  • Lifespan extension in Caenorhabditis elegans by complete removal of food.

    Tammi L. Kaeberlein;Erica D. Smith;Mitsuhiro Tsuchiya;K. Linnea Welton

  • Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

    Fresnida J. Ramos;Steven C. Chen;Michael G. Garelick;Dao Fu Dai

Frequent Co-Authors

Brian K. Kennedy
Brian K. Kennedy National University of Singapore
Yousin Suh
Yousin Suh Columbia University
Daniel E. L. Promislow
Daniel E. L. Promislow University of Washington
Peter S. Rabinovitch
Peter S. Rabinovitch University of Washington
Daniel B. Carr
Daniel B. Carr Tufts University
Stanley Fields
Stanley Fields University of Washington
Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Vadim N. Gladyshev
Vadim N. Gladyshev Brigham and Women's Hospital
Thomas E. Johnson
Thomas E. Johnson University of Colorado Boulder

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