Shin-ichiro Imai

Overview

Best Publications

• Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

  Shin-ichiro Imai;Christopher M. Armstrong;Matt Kaeberlein;Leonard Guarente

  4141
  Citations

• hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

  Homayoun Vaziri;Scott K. Dessain;Scott K. Dessain;Elinor Ng Eaton;Shin Ichiro Imai

  3284
  Citations

• Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

  Jianyuan Luo;Anatoly Y. Nikolaev;Shin ichiro Imai;Delin Chen

  2685
  Citations

• Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice

  Jun Yoshino;Kathryn F. Mills;Myeong Jin Yoon;Shin-ichiro Imai

  1291
  Citations

• NAD+ and sirtuins in aging and disease

  Shin-Ichiro Imai;Leonard Pershing Guarente

  1256
  Citations

• Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

  Kathryn Moynihan Ramsey;Jun Yoshino;Cynthia S. Brace;Dana Abrassart

  1240
  Citations

• The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells.

  Javier R. Revollo;Andrew A. Grimm;Shin Ichiro Imai

  1151
  Citations

• Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme

  Javier R. Revollo;Antje Körner;Kathryn F. Mills;Akiko Satoh

  1136
  Citations

• Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice

  Kathryn A. Moynihan;Andrew A. Grimm;Marie M. Plueger;Ernesto Bernal-Mizrachi

  790
  Citations

• NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

  Jun Yoshino;Joseph A. Baur;Shin ichiro Imai;Shin ichiro Imai

  787
  Citations

• Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

  Akiko Satoh;Cynthia S. Brace;Nick Rensing;Paul Cliften

  780
  Citations

• Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.

  Kathryn F. Mills;Shohei Yoshida;Liana R. Stein;Alessia Grozio

  721
  Citations

• The dynamic regulation of NAD metabolism in mitochondria

  Liana Roberts Stein;Shin-ichiro Imai

  535
  Citations

• Nampt: linking NAD biology, metabolism and cancer.

  Antje Garten;Stefanie Petzold;Antje Körner;Shin-ichiro Imai

  493
  Citations

• Poly(ADP-ribose) Polymerase-1-dependent Cardiac Myocyte Cell Death during Heart Failure Is Mediated by NAD+ Depletion and Reduced Sir2α Deacetylase Activity *

  Jyothish B. Pillai;Ayman Isbatan;Shin Ichiro Imai;Mahesh P. Gupta

  473
  Citations

• Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

  Shin-ichiro Imai;Leonard Pershing Guarente

  472
  Citations

• Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

  Jun Yoshino;Caterina Conte;Caterina Conte;Luigi Fontana;Bettina Mittendorfer

  425
  Citations

• The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals.

  Javier R Revollo;Andrew A Grimm;Shin-ichiro Imai

  378
  Citations

• Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice.

  Kathryn Moynihan Ramsey;Kathryn F. Mills;Akiko Satoh;Shin Ichiro Imai

  350
  Citations

• Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.

  Tao Wang;Xiangbin Zhang;Poonam Bheda;Javier R. Revollo

  345
  Citations