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Eduardo N. Chini

Eduardo N. Chini

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
13227
World Ranking
14297
National Ranking
6025

Overview

Eduardo N. Chini is affiliated with the Mayo Clinic in the United States. Their research spans several disciplines within biochemistry, genetics, molecular biology, and medicine, with notable contributions across physiology, molecular biology, geriatrics and gerontology, immunology, and genetics.

The scientist's work covers key topics including calcium signaling and nucleotide metabolism, adenosine and purinergic signaling, sirtuins and resveratrol in medicine, telomeres, telomerase, and senescence, PARP inhibition in cancer therapy, tryptophan and brain disorders, and genetic and kidney cyst diseases.

Among their recent papers are the following:

  • Mitochondrial dysfunction in cell senescence and aging (2022, Journal of Clinical Investigation)
  • CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels (2020, Nature Metabolism)
  • Evolving concepts in NAD+ metabolism (2021, Cell Metabolism)
  • Tissue-resident CD8 + T cells drive age-associated chronic lung sequelae after viral pneumonia (2020, Science Immunology)
  • A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease (2021, Cell Metabolism)

Frequent collaborators in their work include Claudia C.S. Chini, Thais Peclat, Sonu Kashyap, Julianna D. Zeidler, and Gina M. Warner.

The researcher has commonly published in the following venues:

  • SSRN Electronic Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation
  • Cell Metabolism
  • Aging Cell

Best Publications

  • CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

    Juliana Camacho-Pereira;Juliana Camacho-Pereira;Mariana G. Tarragó;Claudia C.S. Chini;Veronica Nin

  • Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

    Allyson K. Palmer;Ming Xu;Ming Xu;Yi Zhu;Tamar Pirtskhalava

  • Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

    Allyson K. Palmer;Tamara Tchkonia;Nathan K. LeBrasseur;Eduardo N. Chini

  • Regulation of intracellular levels of NAD: a novel role for CD38.

    Pinar Aksoy;Thomas A. White;Michael Thompson;Eduardo N. Chini

  • Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

    Carlos Escande;Veronica Nin;Nathan L. Price;Verena Capellini

  • A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

    Mariana G. Tarragó;Claudia C.S. Chini;Karina S. Kanamori;Gina M. Warner

  • The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity

    Maria Thereza P. Barbosa;Sandra M. Soares;Colleen M. Novak;David Sinclair

  • Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii

    Kisaburo Nagamune;Leslie M. Hicks;Blima Fux;Fabien Brossier;Fabien Brossier

  • The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases.

    Kelly A. Hogan;Claudia C. S. Chini;Eduardo N. Chini

  • Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice

    Carlos Escande;Claudia C S Chini;Veronica Nin;Katherine Minter Dykhouse

  • CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.

    Claudia C.S. Chini;Thais R. Peclat;Gina M. Warner;Sonu Kashyap

  • CD38 as a Regulator of Cellular NAD: A Novel Potential Pharmacological Target for Metabolic Conditions

    Eduardo Nunes Chini

  • NICOTINATE ADENINE DINUCLEOTIDE PHOSPHATE (NAADP) TRIGGERS A SPECIFIC CALCIUM RELEASE SYSTEM IN SEA URCHIN EGGS

    Eduardo N. Chini;Kelly W. Beers;Thomas P. Dousa

  • The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging

    Eduardo N. Chini;Claudia C.S. Chini;Jair Machado Espindola Netto;Guilherme C. de Oliveira

  • NAD and the aging process: Role in life, death and everything in between.

    Claudia C.S. Chini;Mariana G. Tarragó;Eduardo N. Chini

  • Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway.

    Eduardo N. Chini;Eunhee Choi;Joseph P. Grande;John C. Burnett

  • Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38.

    Pinar Aksoy;Carlos Escande;Thomas A. White;Michael Thompson

  • Cytoprotective effects of adrenomedullin in glomerular cell injury: Central role of cAMP signaling pathway

    Eduardo N. Chini;Claudia C.S. Chini;Chad Bolliger;Michihisa Jougasaki

  • Evolving concepts in NAD+ metabolism.

    Claudia C.S. Chini;Julianna D. Zeidler;Sonu Kashyap;Gina Warner

  • Food Restriction Ameliorates the Development of Polycystic Kidney Disease

    Gina Warner;Kyaw Zaw Hein;Veronica Nin;Marika Edwards

Frequent Co-Authors

Thomas A. White
Thomas A. White Mayo Clinic
Joseph P. Grande
Joseph P. Grande Mayo Clinic
David A. Sinclair
David A. Sinclair Harvard University
Gary C. Sieck
Gary C. Sieck Mayo Clinic
Colleen M. Novak
Colleen M. Novak Kent State University
Tamar Tchkonia
Tamar Tchkonia Cedars-Sinai Medical Center
John T. Penniston
John T. Penniston Harvard University
James A. Levine
James A. Levine Mayo Clinic
L. David Sibley
L. David Sibley Washington University in St. Louis

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