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Biology and Biochemistry

D-Index
64
Citations
14580
World Ranking
9675
National Ranking
4267

Overview

Timothy F. Walseth is affiliated with the University of Minnesota in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with particular attention to physiology, sensory systems, pharmacology, molecular biology, and biomedical engineering. The scientist's work extensively covers topics related to calcium signaling and nucleotide metabolism, adenosine and purinergic signaling, ion channels and receptors, as well as specialized areas such as Piperaceae chemical and biological studies, analog and mixed-signal circuit design, and ion channel regulation and function.

Throughout their career, Timothy F. Walseth has published multiple scientific papers, several of which appeared in the journal Science Signaling. Notable publications include:

  • Essential requirement for JPT2 in NAADP-evoked Ca 2+ signaling, 2021, Science Signaling
  • HN1L/JPT2: A signaling protein that connects NAADP generation to Ca 2+ microdomain formation, 2021, Science Signaling
  • Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12, 2023, Science Signaling
  • Role of CD38/cADPR signaling in obstructive pulmonary diseases, 2020, Current Opinion in Pharmacology
  • NAADP: From Discovery to Mechanism, 2021, Frontiers in Immunology

Their frequent co-authors, contributing to multiple publications, include Gihan S. Gunaratne, James T. Slama, Jonathan S. Marchant, Eugen Brailoiu, and Sandip Patel.

Timothy F. Walseth's work has appeared most often in the following publication venues:

  • Science Signaling
  • Bioorganic & Medicinal Chemistry
  • Current Opinion in Pharmacology
  • Frontiers in Immunology
  • Molecules

Best Publications

  • Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38

    M. Howard;J. C. Grimaldi;J. F. Bazan;F. E. Lund

  • Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

    DL Clapper;TF Walseth;PJ Dargie;Hon Cheung Lee

  • Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity.

    Hon Cheung Lee;T. F. Walseth;G. T. Bratt;R. N. Hayes

  • ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP.

    Robert Aarhus;Richard M. Graeff;Deborah M. Dickey;Timothy F. Walseth

  • Calcium mobilization by dual receptors during fertilization of sea urchin eggs

    Hon Cheung Lee;Robert Aarhus;Timothy F. Walseth

  • Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release

    Timothy F. Walseth;Hon Cheung Lee

  • Enzymatic synthesis and characterizations of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity.

    R. M. Graeff;T. F. Walseth;K. Fryxell;W. D. Branton

  • Cyclic ADP ribose activation of the ryanodine receptor is mediated by calmodulin

    Hon Cheung Lee;Robert Aarhus;Richard M Graeff;Mary E. Gurnack

  • Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations.

    R. Paul Robertson;Hui Jian Zhang;Kathryn L. Pyzdrowski;Timothy F. Walseth

  • Similarities in amino acid sequences of Aplysia ADP-ribosyl cyclase and human lymphocyte antigen CD38.

    David J. States;Timothy F. Walseth;Hon Cheung Lee

  • Nitric Oxide-induced Mobilization of Intracellular Calcium via the Cyclic ADP-ribose Signaling Pathway

    Nick Willmott;Jaswinder K. Sethi;Timothy F. Walseth;Hon Cheung Lee

  • CD38/cyclic ADP-ribose-mediated Ca2+ signaling contributes to airway smooth muscle hyper-responsiveness

    Deepak A. Deshpande;Timothy F. Walseth;Reynold A. Panettieri;Mathur S. Kannan

  • Activation and Inactivation of Ca Release by NAADP

    Robert Aarhus;Deborah M. Dickey;Richard M. Graeff;Kyle R. Gee

  • Cyclic AMP and LDL trigger a rapid enhancement in gap junction assembly through a stimulation of connexin trafficking

    Alicia F. Paulson;Paul D. Lampe;Rita A. Meyer;Erica TenBroek

  • Modulation of calcium signaling by interleukin-13 in human airway smooth muscle: role of CD38/cyclic adenosine diphosphate ribose pathway.

    Deepak A. Deshpande;Soner Dogan;Timothy F. Walseth;Steven M. Miller

  • Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

    Yaping Lin-Moshier;Timothy F. Walseth;Dev Churamani;Sean M. Davidson

  • Role of cyclic ADP-ribose in the regulation of [Ca2+]i in porcine tracheal smooth muscle

    Y. S. Prakash;Mathur S. Kannan;Timothy F. Walseth;Gary C. Sieck

  • Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

    Margarida Ruas;Lianne C. Davis;Cheng Chang Chen;Anthony J. Morgan

  • Identification of the enzymatic active site of CD38 by site-directed mutagenesis.

    Cyrus Munshi;Robert Aarhus;Richard Graeff;Timothy F. Walseth

  • Determination of endogenous levels of cyclic ADP-ribose in rat tissues.

    Timothy F. Walseth;Robert Aarhus;Robert J. Zeleznikar;Hon Cheung Lee

Frequent Co-Authors

Hon Cheung Lee
Hon Cheung Lee Peking University Shenzhen Graduate School
Reynold A. Panettieri
Reynold A. Panettieri Rutgers, The State University of New Jersey
Subbaya Subramanian
Subbaya Subramanian University of Minnesota
Frances E. Lund
Frances E. Lund University of Alabama at Birmingham
Thomas A. White
Thomas A. White Mayo Clinic
Sandip Patel
Sandip Patel University College London
Gary C. Sieck
Gary C. Sieck Mayo Clinic
Yassine Amrani
Yassine Amrani University of Leicester
Julian Solway
Julian Solway University of Chicago
Antony Galione
Antony Galione University of Oxford

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