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Antonio De Flora

Antonio De Flora

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
9388
World Ranking
12827
National Ranking
388

Overview

Antonio De Flora is affiliated with the University of Genoa in Italy and has contributed to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields, including Physiology, Geriatrics and Gerontology, Molecular Biology, Sensory Systems, and Oncology.

De Flora's research covers a range of topics with particular emphasis on Calcium signaling and nucleotide metabolism, Sirtuins and Resveratrol in Medicine, Adipose Tissue and Metabolism, Adenosine and Purinergic Signaling, Ion Channels and Receptors, Metabolism, Diabetes, and Cancer, and Pancreatic function and diabetes.

Some of the recent papers published by De Flora include:

  • Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation (2020, Scientific Reports)
  • CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues (2020, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids)
  • The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice (2024, Frontiers in Endocrinology)
  • CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD+-Lowering Agents (2023, Antioxidants)
  • SIRT6 pharmacological inhibition delays skin cancer progression in the squamous cell carcinoma (2023, Biomedicine & Pharmacotherapy)

De Flora has published frequently in the journals Cells, Scientific Reports, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Frontiers in Endocrinology, and Antioxidants. These venues reflect the scope and interdisciplinary nature of their research.

Collaborations are a notable aspect of De Flora's scientific outputs. Frequent coauthors include Santina Bruzzone, Laura Sturla, Andrea Benzi, Sonia Spinelli, and Elena Zocchi, with counts of 9, 8, 7, 5, and 4 coauthored publications respectively. These collaborations indicate a consistent research network focused on related scientific themes.

Best Publications

  • Connexin 43 hemichannels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells

    Santina Bruzzone;Lucrezia Guida;Elena Zocchi;Luisa Franco

  • Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger

    Santina Bruzzone;Iliana Moreschi;Cesare Usai;Lucrezia Guida

  • Autocrine and Paracrine Calcium Signaling by the CD38/NAD+/Cyclic ADP‐Ribose System

    Antonio De Flora;Elena Zocchi;Lucrezia Guida;Luisa Franco

  • In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds

    Silvio De Flora;Carlo Bennicelli;Anna Camoirano;Domizio Serra

  • Synthesis of GDP-L-fucose by the Human FX Protein

    Michela Tonetti;Laura Sturla;Angela Bisso;Umberto Benatti

  • Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger

    Santina Bruzzone;Nicoletta Bodrato;Cesare Usai;Lucrezia Guida

  • T-cell suppression mediated by mesenchymal stem cells is deficient in patients with severe aplastic anemia.

    Andrea Bacigalupo;Marisa Valle;Marina Podestà;Anna Pitto

  • The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes

    Luisa Franco;Lucrezia Guida;Santina Bruzzone;Elena Zocchi

  • Evidence of a role for cyclic ADP‐ribose in calcium signalling and neurotransmitter release in cultured astrocytes

    Claudia Verderio;Santina Bruzzone;Elena Zocchi;Ernesto Fedele

  • Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes.

    Iliana Moreschi;Santina Bruzzone;Robert A. Nicholas;Floriana Fruscione

  • CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells

    Alessia Grozio;Giovanna Sociali;Laura Sturla;Irene Caffa

  • LANCL2 Is Necessary for Abscisic Acid Binding and Signaling in Human Granulocytes and in Rat Insulinoma Cells

    Laura Sturla;Chiara Fresia;Lucrezia Guida;Santina Bruzzone

  • Expression of CD38 Increases Intracellular Calcium Concentration and Reduces Doubling Time in HeLa and 3T3 Cells

    Elena Zocchi;Antonio Daga;Cesare Usai;Luisa Franco

  • A self-restricted CD38-connexin 43 cross-talk affects NAD+ and cyclic ADP-ribose metabolism and regulates intracellular calcium in 3T3 fibroblasts.

    Santina Bruzzone;Luisa Franco;Lucrezia Guida;Elena Zocchi

  • Paracrine roles of NAD+ and cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts.

    Luisa Franco;Elena Zocchi;Cesare Usai;Lucrezia Guida

  • Cyclic GMP-dependent and -independent Effects on the Synthesis of the Calcium Messengers Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate

    Richard M. Graeff;Luisa Franco;Antonio De Flora;Hon Cheung Lee

  • Identification and characterization of an active soluble form of human CD38 in normal and pathological fluids.

    Ada Funaro;Alberto L. Horenstein;Liliana Calosso;Massimo Morra

  • Ligand-induced internalization of CD38 results in intracellular Ca2+ mobilization: role of NAD+ transport across cell membranes

    Elena Zocchi;Cesare Usai;Lucrezia Guida;Luisa Franco

  • The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.

    Silvia Garavaglia;Santina Bruzzone;Camilla Cassani;Laura Canella

  • Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis.

    Mirko Magnone;Santina Bruzzone;Lucrezia Guida;Gianluca Damonte

Frequent Co-Authors

Elena Zocchi
Elena Zocchi University of Genoa
Santina Bruzzone
Santina Bruzzone University of Genoa
Umberto Benatti
Umberto Benatti University of Genoa
Mauro Magnani
Mauro Magnani University of Urbino
Edon Melloni
Edon Melloni University of Genoa
Sandro Pontremoli
Sandro Pontremoli University of Genoa
Andrea Bacigalupo
Andrea Bacigalupo Catholic University of the Sacred Heart
Bianca Sparatore
Bianca Sparatore University of Genoa
Alessio Nencioni
Alessio Nencioni University of Genoa
Martino Bolognesi
Martino Bolognesi University of Milan

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