World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
127
Citations
61653
World Ranking
468
National Ranking
301

Medicine

D-Index
127
Citations
61618
World Ranking
2823
National Ranking
1574

Overview

H. Phillip Koeffler is affiliated with Cedars-Sinai Medical Center in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, as well as medicine. Koeffler has contributed extensively to subfields including molecular biology, oncology, immunology, cancer research, and hematology.

The scientist's work addresses several key topics, notably:

  • RNA modifications and cancer
  • Cancer-related gene regulation
  • Epigenetics and DNA methylation
  • Protein degradation and inhibitors
  • RNA research and splicing
  • Genomics and chromatin dynamics
  • Acute myeloid leukemia research

Koeffler's publication record includes recent papers that cover diverse aspects of cancer biology and molecular mechanisms, such as:

  • Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment, 2021, Nature Communications
  • Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas, 2020, Molecular Cancer
  • TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines, 2020, Gastroenterology
  • Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer, 2021, Nature Communications
  • PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells, 2022, Cancer Research

Their frequent collaborators include:

  • De-Chen Lin (20 publications)
  • Pushkar Dakle (13 publications)
  • Yueyuan Zheng (13 publications)
  • Ling-Wen Ding (13 publications)
  • Vikas Madan (12 publications)

Koeffler has a notable publication presence in several scientific journals, contributing multiple times to:

  • Cancer Research (8 publications)
  • Nature Communications (7 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (6 publications)
  • Oncogene (4 publications)
  • Blood (3 publications)

Best Publications

  • Maftools: efficient and comprehensive analysis of somatic variants in cancer.

    Anand Mayakonda;Anand Mayakonda;De Chen Lin;Yassen Assenov;Yassen Assenov;Christoph Plass;Christoph Plass

  • Frequent pathway mutations of splicing machinery in myelodysplasia

    Kenichi Yoshida;Masashi Sanada;Yuichi Shiraishi;Daniel Nowak

  • Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

    T Haferlach;Y Nagata;V Grossmann;Y Okuno

  • Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3

    Adrian F. Gombart;Niels Borregaard;H. Phillip Koeffler

  • Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions.

    Maximilien Evrard;Immanuel W.H. Kwok;Immanuel W.H. Kwok;Shu Zhen Chong;Karen W.W. Teng

  • The Circadian Gene Per1 Plays an Important Role in Cell Growth and DNA Damage Control in Human Cancer Cells

    Sigal Gery;Naoki Komatsu;Lilit Baldjyan;Andrew Yu

  • Genomic and molecular characterization of esophageal squamous cell carcinoma

    De-Chen Lin;De-Chen Lin;Jia-Jie Hao;Yasunobu Nagata;Liang Xu

  • Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes

    Yasunobu Nagata;Vera Grossmann;Yusuke Okuno;Ulrike Bacher

  • Capsaicin, a Component of Red Peppers, Inhibits the Growth of Androgen-Independent, p53 Mutant Prostate Cancer Cells

    Akio Mori;Sören Lehmann;James O'Kelly;Takashi Kumagai

  • Peroxisome proliferator-activated receptor γ and cancers

    H. Phillip Koeffler

  • Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.

    Masashi Sanada;Takahiro Suzuki;Lee-Yung Shih;Makoto Otsu

  • Absence of WAF1 Mutations in a Variety of Human Malignancies

    M. Shiohara;W. S. El-Deiry;M. Wada;T. Nakamaki

  • Differentiation therapy of leukemia: 3 decades of development

    Daniel Nowak;Daphne Stewart;H. Phillip Koeffler

  • Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

    Ayana Kon;Lee Yung Shih;Masashi Minamino;Masashi Sanada;Masashi Sanada

  • AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo

    Jing Yang;Takayuki Ikezoe;Chie Nishioka;Taizo Tasaka

  • Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.

    Wolf-K. Hofmann;Letetia C. Jones;Nathan A. Lemp;Sven de Vos

  • The genomic landscape of nasopharyngeal carcinoma

    De-Chen Lin;Xuan Meng;Masaharu Hazawa;Yasunobu Nagata

  • Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

    I Wolf;S Levanon-Cohen;S Levanon-Cohen;S Bose;H Ligumsky

  • Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.

    Adrian F. Gombart;Wolf-K. Hofmann;Seiji Kawano;Seisho Takeuchi

  • Frequent Pathway Mutations of Splicing Machinery in Myelodysplasia

    Kenichi Yoshida;Masashi Sanada;Yuichi Shiraishi;Daniel Nowak

Frequent Co-Authors

Seishi Ogawa
Seishi Ogawa Kyoto University
Jonathan W. Said
Jonathan W. Said University of California, Los Angeles
Henry Yang
Henry Yang National University of Singapore
Adrian F. Gombart
Adrian F. Gombart Oregon State University
Masashi Sanada
Masashi Sanada Kyoto University
Torsten Haferlach
Torsten Haferlach MLL Munich Leukemia Laboratory
Markus Müschen
Markus Müschen Yale University
kenichi yoshida
kenichi yoshida Kyoto University
Satoru Miyano
Satoru Miyano Tokyo Medical and Dental University
Claus R. Bartram
Claus R. Bartram Heidelberg University

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Related Online Degrees & Career Pathways

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