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D-Index & Metrics

Medicine

D-Index
119
Citations
56477
World Ranking
3874
National Ranking
2120

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Omar Abdel-Wahab is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research primarily spans various areas within medicine and biochemistry, genetics, and molecular biology, with a focus on molecular biology, hematology, genetics, immunology, and cancer research as key subfields.

The scientist has contributed extensively to the study of hematologic malignancies and cancer biology, with main topics including acute myeloid leukemia research, RNA research and splicing, RNA modifications and cancer, chronic lymphocytic leukemia research, myeloproliferative neoplasms diagnosis and treatment, cancer genomics and diagnostics, and histiocytic disorders and treatments.

Abdel-Wahab's recent notable papers include:

  • "Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study" published in The Lancet in 2021
  • "Pharmacologic modulation of RNA splicing enhances anti-tumor immunity" published in Cell in 2021
  • "DNA methylation disruption reshapes the hematopoietic differentiation landscape" published in Nature Genetics in 2020
  • "Improved prediction of immune checkpoint blockade efficacy across multiple cancer types" published in Nature Biotechnology in 2021
  • "Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML" published in Blood Advances in 2021

Frequent co-authors collaborating with Abdel-Wahab include:

  • Justin Taylor
  • Benjamin H. Durham
  • Robert K. Bradley
  • Ross L. Levine
  • Eli L. Diamond

In terms of publication venues, Abdel-Wahab has contributed prolifically to:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood Advances
  • Leukemia
  • Cancer Research

The scientist has been recognized as a member of the Association of American Physicians.

Best Publications

  • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

    Maria E. Figueroa;Omar Abdel-Wahab;Chao Lu;Patrick S. Ward

  • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

    Jay P. Patel;Mithat Gönen;Maria E. Figueroa;Hugo Fernandez

  • The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

    Patrick S. Ward;Jay Patel;David R. Wise;Omar Abdel-Wahab

  • IDH mutation impairs histone demethylation and results in a block to cell differentiation

    Chao Lu;Patrick S. Ward;Patrick S. Ward;Gurpreet S. Kapoor;Dan Rohle;Dan Rohle

  • Clinical effect of point mutations in myelodysplastic syndromes.

    Rafael Bejar;Kristen Stevenson;Omar Abdel-Wahab;Naomi Galili

  • Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.

    Jean-François Emile;Oussama Abla;Sylvie Fraitag;Annacarin Horne

  • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

    Kelly Moran-Crusio;Linsey Reavie;Alan Shih;Omar Abdel-Wahab

  • EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

    Wendy Béguelin;Relja Popovic;Matt Teater;Yanwen Jiang

  • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

    Lambert Busque;Jay P Patel;Maria E Figueroa;Aparna Vasanthakumar

  • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

    Omar Abdel-Wahab;Ann Mullally;Cyrus Hedvat;Guillermo Garcia-Manero

  • The role of mutations in epigenetic regulators in myeloid malignancies

    Alan H. Shih;Omar Abdel-Wahab;Jay P. Patel;Ross L. Levine

  • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.

    Omar Abdel-Wahab;Mazhar Adli;Lindsay M. LaFave;Jie Gao

  • Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

    Luisa Cimmino;Igor Dolgalev;Yubao Wang;Akihide Yoshimi

  • RNA splicing factors as oncoproteins and tumour suppressors

    Heidi Dvinge;Eunhee Kim;Omar Abdel-Wahab;Robert K. Bradley

  • Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease

    Eli L. Diamond;Lorenzo Dagna;David M. Hyman;Giulio Cavalli

  • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis

    A. Tefferi;A. Pardanani;K. H. Lim;K. H. Lim;O. Abdel-Wahab

  • SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

    Eunhee Kim;Janine O. Ilagan;Yang Liang;Gerrit M. Daubner

  • Validation of a Prognostic Model and the Impact of Mutations in Patients With Lower-Risk Myelodysplastic Syndromes

    Rafael Bejar;Kristen E. Stevenson;Bennett A. Caughey;Omar Abdel-Wahab

  • BET inhibitor resistance emerges from leukaemia stem cells

    Chun Yew Fong;Omer Gilan;Omer Gilan;Enid Y N Lam;Alan Rubin

  • Therapeutic targeting of splicing in cancer

    Stanley Chun-Wei Lee;Omar Abdel-Wahab

Frequent Co-Authors

Ross L. Levine
Ross L. Levine Memorial Sloan Kettering Cancer Center
Martin S. Tallman
Martin S. Tallman Northwestern University
Ari Melnick
Ari Melnick Cornell University
Robert K. Bradley
Robert K. Bradley Fred Hutchinson Cancer Research Center
David M. Hyman
David M. Hyman Memorial Sloan Kettering Cancer Center
Ahmet Dogan
Ahmet Dogan Memorial Sloan Kettering Cancer Center
Iannis Aifantis
Iannis Aifantis New York University
Maria E. Figueroa
Maria E. Figueroa University of Miami
Neal Rosen
Neal Rosen Memorial Sloan Kettering Cancer Center
Benjamin L. Ebert
Benjamin L. Ebert Harvard University

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