Iannis Aifantis mainly focuses on Cancer research, Haematopoiesis, Leukemia, Immunology and Signal transduction. His research in Cancer research intersects with topics in PRC2, Mutation, Progenitor cell, Histone and Hematopoietic stem cell. His Haematopoiesis study is concerned with Stem cell in general.
He has included themes like Oncogene and Myeloid leukemia in his Leukemia study. His study on Signal transduction is covered under Cell biology. His studies deal with areas such as T cell and Molecular biology as well as T-cell leukemia.
His scientific interests lie mostly in Cancer research, Cell biology, Immunology, Leukemia and Haematopoiesis. His work deals with themes such as Mutation, Epigenetics and Notch signaling pathway, which intersect with Cancer research. His Cell biology research incorporates elements of T cell, Ubiquitin, Ubiquitin ligase and Cellular differentiation.
His Immunology study frequently links to other fields, such as Progenitor cell. His Leukemia research includes themes of Molecular biology and Oncogene. His Haematopoiesis study deals with the bigger picture of Stem cell.
His main research concerns Cancer research, Cell biology, Leukemia, Cancer and Myeloid leukemia. His Cancer research study incorporates themes from T cell, Downregulation and upregulation, Germinal center, B cell and Bone marrow. His research in Cell biology is mostly focused on Stem cell.
His biological study focuses on Haematopoiesis. The study incorporates disciplines such as Myeloid and Innate immune system in addition to Haematopoiesis. His studies in Leukemia integrate themes in fields like Precursor cell and DISEASE RELAPSE.
Iannis Aifantis mainly investigates Cell biology, Cancer research, Stem cell, Epigenetics and Leukemia. Iannis Aifantis studies Signal transduction, a branch of Cell biology. He does research in Cancer research, focusing on Melanoma specifically.
His Stem cell research integrates issues from Regulation of gene expression, Transcriptome, Cellular differentiation and Single-cell analysis. His Epigenetics study combines topics in areas such as Chromatin, CTCF, DNA methylation and Acute leukemia. His work carried out in the field of Leukemia brings together such families of science as Azacitidine, Mitochondrion and CLPB.
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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Kelly Moran-Crusio;Linsey Reavie;Alan Shih;Omar Abdel-Wahab.
Cancer Cell (2011)
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
Omar Abdel-Wahab;Mazhar Adli;Lindsay M. LaFave;Jie Gao.
Cancer Cell (2012)
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Benjamin J. Thompson;Silvia Buonamici;Maria Luisa Sulis;Teresa Palomero.
Journal of Experimental Medicine (2007)
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
Panagiotis Ntziachristos;Panagiotis Ntziachristos;Aristotelis Tsirigos;Pieter Van Vlierberghe;Jelena Nedjic.
Nature Medicine (2012)
Molecular pathogenesis of T-cell leukaemia and lymphoma
Iannis Aifantis;Elizabeth Raetz;Silvia Buonamici.
Nature Reviews Immunology (2008)
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Luisa Cimmino;Igor Dolgalev;Yubao Wang;Akihide Yoshimi.
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J Real;Valeria Tosello;Teresa Palomero;Teresa Palomero;Mireia Castillo.
Nature Medicine (2009)
SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition
Eunhee Kim;Janine O. Ilagan;Yang Liang;Gerrit M. Daubner.
Cancer Cell (2015)
The bone marrow microenvironment at single-cell resolution.
Anastasia N. Tikhonova;Igor Dolgalev;Hai Hu;Kishor K Sivaraj.
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
Tomas Vilimas;Joaquina Mascarenhas;Teresa Palomero;Malay Mandal.
Nature Medicine (2007)
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