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Juan Carlos Zúñiga-Pflücker

Juan Carlos Zúñiga-Pflücker

D-Index & Metrics

Immunology

D-Index
76
Citations
23002
World Ranking
1897
National Ranking
39

Overview

Juan Carlos Zúñiga-Pflücker is affiliated with the University of Toronto in Canada. Their research primarily spans the fields of Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine. Within these disciplines, their work emphasizes subfields such as Immunology, Molecular Biology, Oncology, Cancer Research, and Endocrine and Autonomic Systems.

The scientist's research focuses on several key topics, including:

  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Epigenetics and DNA Methylation
  • Pluripotent Stem Cells Research
  • CRISPR and Genetic Engineering

Juan Carlos Zúñiga-Pflücker has contributed to academic literature with a number of recent papers covering various aspects of immunology and cell biology. Notable publications include:

  • "DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system" (2021), published in Nature Communications
  • "A 2020 View of Thymus Stromal Cells in T Cell Development" (2021), published in The Journal of Immunology
  • "Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection" (2020), published in Proceedings of the National Academy of Sciences
  • "Thymus aging and immune reconstitution, progresses and challenges" (2023), published in Seminars in Immunology
  • "The E protein-TCF1 axis controls γδ T cell development and effector fate" (2021), published in Cell Reports

The scientist has collaborated frequently with several researchers, including Michele K. Anderson, Mahmood Mohtashami, Jianxun Han, David L. Wiest, and Edward L.Y. Chen.

Juan Carlos Zúñiga-Pflücker's work is often published in venues such as The Journal of Immunology, Frontiers in Immunology, Cell Reports, bioRxiv (Cold Spring Harbor Laboratory), and Nature Communications. The Journal of Immunology and Frontiers in Immunology represent the most frequent platforms for their research dissemination.

In addition to journal articles, they have authored a book titled Molecular Switches of the Immune System: The E Protein/Id Axis in Hematopoietic Development and Function, published by Frontiers Media in 2022.

Best Publications

  • Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

    Nicholas Joza;Nicholas Joza;Santos A. Susin;Eric Daugas;William L. Stanford

  • Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

    Thomas M. Schmitt;Juan Carlos Zúñiga-Pflücker

  • Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

    Teresa Palomero;Maria Luisa Sulis;Maria Cortina;Pedro J Real

  • T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis

    Jeffrey M. Critchfield;Michael K. Racke;Juan Carlos Zúñiga-Pflücker;Barbara Cannella

  • Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus

    Howard T Petrie;Juan Carlos Zúñiga-Pflücker

  • IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

    Masato Sasaki;Christiane B. Knobbe;Christiane B. Knobbe;Joshua C. Munger;Evan F. Lind

  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.

    Maria Ciofani;Juan Carlos Zúñiga-Pflücker

  • Heterogeneity among DN1 Prothymocytes Reveals Multiple Progenitors with Different Capacities to Generate T Cell and Non-T Cell Lineages

    Helen E Porritt;Lynn L Rumfelt;Sahba Tabrizifard;Thomas M Schmitt

  • Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro.

    Thomas M Schmitt;Renée F de Pooter;Matthew A Gronski;Sarah K Cho;Sarah K Cho

  • T Lymphocyte Potential Marks the Emergence of Definitive Hematopoietic Progenitors in Human Pluripotent Stem Cell Differentiation Cultures

    Marion Kennedy;Geneve Awong;Geneve Awong;Christopher M. Sturgeon;Andrea Ditadi

  • T-cell development made simple

    Juan Carlos Zúñiga-Pflücker

  • Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions

    Thomas M. Schmitt;Maria Ciofani;Howard T. Petrie;Juan Carlos Zúñiga-Pflücker

  • Early hematopoietic lineage restrictions directed by Ikaros.

    Toshimi Yoshida;Samuel Yao-Ming Ng;Juan Carlos Zuniga-Pflucker;Katia Georgopoulos

  • Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro

    Ross N. La Motte-Mohs;Elaine Herer;Elaine Herer;Juan Carlos Zúñiga-Pflücker;Juan Carlos Zúñiga-Pflücker

  • Commitment and Developmental Potential of Extrathymic and Intrathymic T Cell Precursors: Plenty to Choose from

    Avinash Bhandoola;Harald von Boehmer;Howard T. Petrie;Juan Carlos Zúñiga-Pflücker

  • Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation

    Maria Ciofani;Gisèle C. Knowles;David L. Wiest;Harald von Boehmer

  • Obligatory Role for Cooperative Signaling by Pre-TCR and Notch during Thymocyte Differentiation

    Maria Ciofani;Thomas M. Schmitt;Amelia Ciofani;Alison M. Michie

  • The thymus as an inductive site for T lymphopoiesis.

    Maria Ciofani;Juan Carlos Zúñiga-Pflücker

  • Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.

    Alison M Michie;Juan Carlos Zúñiga-Pflücker

  • An Overview of the Intrathymic Intricacies of T Cell Development

    Divya K. Shah;Juan Carlos Zúñiga-Pflücker

Frequent Co-Authors

David L. Wiest
David L. Wiest Fox Chase Cancer Center
Michael J. Lenardo
Michael J. Lenardo National Institute of Allergy and Infectious Diseases
Pamela S. Ohashi
Pamela S. Ohashi Princess Margaret Cancer Centre
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Howard T. Petrie
Howard T. Petrie Scripps Research Institute
Robert Rottapel
Robert Rottapel University of Toronto
Christopher J. Paige
Christopher J. Paige Princess Margaret Cancer Centre
Marcel R.M. van den Brink
Marcel R.M. van den Brink Memorial Sloan Kettering Cancer Center

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