World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
75
Citations
15532
World Ranking
2017
National Ranking
987

Molecular Biology

D-Index
75
Citations
15511
World Ranking
1209
National Ranking
625

Research.com Recognitions

  • 2019 - Distinguished Fellows of the American Association of Immunologists (AAI)
  • 2018 - Fellow of the American Academy of Arts and Sciences
  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ellen V. Rothenberg is affiliated with the California Institute of Technology in the United States. Their research predominantly focuses on immunology and microbiology, with significant contributions in molecular biology and oncology. The primary emphasis of their work lies in T-cell and B-cell immunology, immune cell function and interaction, single-cell and spatial transcriptomics, as well as CAR-T cell therapy research. Additional topics covered include genomics and chromatin dynamics, CRISPR and genetic engineering, and immunotherapy and immune responses.

Rothenberg has published extensively, with 50 known publications in immunology and 37 in biochemistry, genetics, and molecular biology. Their subfields of specialization include immunology (50 publications), molecular biology (34 publications), oncology (11 publications), cell biology, and cancer research. Frequent publication venues where Rothenberg's work appears include Experimental Hematology, bioRxiv (Cold Spring Harbor Laboratory), Science Immunology, Frontiers in Immunology, and The Journal of Immunology.

Recent notable papers authored or co-authored by Rothenberg include:

  • "How transcription factors drive choice of the T cell fate," 2020, Nature Reviews. Immunology
  • "Single-cell deletion analyses show control of pro-T cell developmental speed and pathways by Tcf7, Spi1, Gata3, Bcl11a, Erg, and Bcl11b," 2022, Science Immunology
  • "Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching," 2021, Proceedings of the National Academy of Sciences
  • "Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development," 2020, The Journal of Cell Biology
  • "Single-cell insights into the hematopoietic generation of T-lymphocyte precursors in mouse and human," 2021, Experimental Hematology

Rothenberg collaborates frequently with several researchers, including Boyoung Shin, Wen Zhou, Fan Gao, Maile Romero-Wolf, and Hiroyuki Hosokawa.

The scientist has been recognized by multiple professional organizations. Awards include the Distinguished Fellows of the American Association of Immunologists (AAI) in 2019, election as Fellow of the American Academy of Arts and Sciences in 2018, and Fellow of the American Association for the Advancement of Science (AAAS) in 2017.

Best Publications

  • Launching the T-cell-lineage developmental programme.

    Ellen V. Rothenberg;Jonathan E. Moore;Mary A. Yui

  • An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b

    Long Li;Mark Leid;Ellen V. Rothenberg

  • Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus

    Tom Taghon;Mary A. Yui;Rashmi Pant;Rochelle A. Diamond

  • Developmental gene networks: a triathlon on the course to T cell identity

    Mary A. Yui;Ellen V. Rothenberg

  • Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity

    Jingli A. Zhang;Ali Mortazavi;Brian A. Williams;Barbara J. Wold

  • Molecular Genetics of T Cell Development

    Ellen V. Rothenberg;Tom Taghon

  • GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation

    Gabriela Hernández-Hoyos;Michele K. Anderson;Chi Wang;Ellen V. Rothenberg

  • Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage

    Michele K. Anderson;Gabriela Hernandez-Hoyos;Rochelle A. Diamond;Ellen V. Rothenberg

  • Positive feedback between PU.1 and the cell cycle controls myeloid differentiation

    Hao Yuan Kueh;Ameya Champhekar;Stephen L. Nutt;Michael B. Elowitz

  • cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells.

    Thomas J. Novak;Ellen V. Rothenberg

  • Lck Activity Controls CD4/CD8 T Cell Lineage Commitment

    Gabriela Hernández-Hoyos;Sue J Sohn;Ellen V Rothenberg;José Alberola-Ila

  • Transcriptional Control of Early T and B Cell Developmental Choices

    Ellen V. Rothenberg

  • How transcription factors drive choice of the T cell fate

    Hiroyuki Hosokawa;Hiroyuki Hosokawa;Ellen V. Rothenberg

  • Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

    Tom Taghon;Mary A Yui;Ellen V Rothenberg

  • A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation

    Ellen V. Rothenberg;Susan B. Ward

  • The development of functionally responsive T cells.

    Ellen V. Rothenberg

  • Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling

    Tom N. Taghon;Elizabeth-Sharon David;Juan Carlos Zúñiga-Pflücker;Ellen V. Rothenberg

  • High frequency of aberrant expression of moloney murine leukemia virus in clonal infections

    Anthony Shields;Owen N. Witte;Ellen Rothenberg;David Baltimore

  • Constitutive Expression of PU.1 in Fetal Hematopoietic Progenitors Blocks T Cell Development at the Pro-T Cell Stage

    Michele K Anderson;Angela H Weiss;Angela H Weiss;Gabriela Hernandez-Hoyos;Gabriela Hernandez-Hoyos;Christopher J Dionne

  • Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles.

    Dan Chen;Ellen V. Rothenberg

  • Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors.

    Paul A. Garrity;Dan Chen;Ellen V. Rothenberg;Barbara J. Wold

Frequent Co-Authors

Tom Taghon
Tom Taghon Ghent University
David Baltimore
David Baltimore California Institute of Technology
Michael B. Elowitz
Michael B. Elowitz California Institute of Technology
Wen Zhou
Wen Zhou Fudan University
Stephen L. Nutt
Stephen L. Nutt Walter and Eliza Hall Institute of Medical Research
Barbara J. Wold
Barbara J. Wold California Institute of Technology
Anjana Rao
Anjana Rao La Jolla Institute For Allergy & Immunology
Lee Rowen
Lee Rowen Institute for Systems Biology in Seattle
Gary W. Litman
Gary W. Litman University of South Florida
Christine Kinnon
Christine Kinnon University College London

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