World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
21201
World Ranking
5887
National Ranking
148

Overview

Frank J.T. Staal is affiliated with Leiden University Medical Center in the Netherlands. Their research spans various intersecting fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. The primary subfields of their work include Molecular Biology, Immunology, Oncology, Genetics, and Infectious Diseases.

The scientist's research topics cover a range of contemporary biomedical themes such as CAR-T cell therapy research, CRISPR and Genetic Engineering, Immune Cell Function and Interaction, Virus-based gene therapy research, T-cell and B-cell Immunology, SARS-CoV-2 and COVID-19 Research, and Immunodeficiency and Autoimmune Disorders.

Frequent coauthors collaborating with Frank J.T. Staal include:

  • Karin Pike-Overzet
  • Kirsten Canté-Barrett
  • Jacques J. M. van Dongen
  • Arjan C. Lankester
  • Sandra A. Vloemans

The scientist has published extensively, with a concentration of papers appearing in venues such as Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Frontiers in Immunology, Cells, Cancer Cell, and Frontiers in Cell and Developmental Biology.

Notable recent publications include:

  • "An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates" (2020, Cancer Cell)
  • "Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis" (2020, Cell Metabolism)
  • "Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?" (2021, Frontiers in Cell and Developmental Biology)
  • "An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates" (2020, Cancer Cell)
  • "Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19" (2021, Nature Immunology)

Best Publications

  • Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

    Steven J. Howe;Marc R. Mansour;Kerstin Schwarzwaelder;Cynthia Bartholomae

  • Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus

    F J Staal;M Roederer;L A Herzenberg

  • Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes

    Cindy J.M. Loomans;Eelco J.P. de Koning;Frank J.T. Staal;Maarten B. Rookmaaker

  • WNT signalling in the immune system: WNT is spreading its wings.

    Frank J. T. Staal;Tiago C. Luis;Machteld M. Tiemessen

  • Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

    M. Roederer;F. J. T. Staal;P. A. Raju;S. W. Ela

  • Glutathione deficiency and human immunodeficiency virus infection.

    F.J.T Staal;S.W Ela;M Roederer;M.T Anderson

  • Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway

    M. T. Anderson;F. J. T. Staal;C. Gitler;L. A. Herzenberg

  • WNT signalling and haematopoiesis: a WNT-WNT situation.

    Frank J.T. Staal;Hans C. Clevers

  • New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling

    Willem A. Dik;Karin Pike-Overzet;Floor Weerkamp;Dick de Ridder;Dick de Ridder

  • Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

    Irene Homminga;Rob Pieters;Anton W. Langerak;Johan J. de Rooi

  • Wnt signals are transmitted through N‐terminally dephosphorylated β‐catenin

    Frank J T Staal;Mascha van Noort;Ger J Strous;Hans C Clevers

  • A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes.

    Roos C. Padmos;Manon H. J. Hillegers;Esther M. Knijff;Ronald Vonk

  • Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

    Tiago C. Luis;Tiago C. Luis;Brigitta A.E. Naber;Brigitta A.E. Naber;Paul P.C. Roozen;Martijn H. Brugman

  • An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

    Jermaine Goveia;Katerina Rohlenova;Federico Taverna;Lucas Treps

  • Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

    Christopher Baum;Christof von Kalle;Frank J.T Staal;Zhixiong Li

  • Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

    Annette Deichmann;Salima Hacein-Bey-Abina;Manfred Schmidt;Manfred Schmidt;Alexandrine Garrigue

  • Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx

    F. J. T. Staal;M. T. Anderson;G. E. J. Staal;L. A. Herzenberg

  • Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

    Frank J. T. Staal;Jan Meeldijk;Petra Moerer;Philippe Jay

  • CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells

    P Res;E Martinez-Caceres;A Cristina Jaleco;F Staal

  • Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

    Kerstin Schwarzwaelder;Steven J. Howe;Manfred Schmidt;Manfred Schmidt;Martijn H. Brugman

Frequent Co-Authors

Jacques J.M. van Dongen
Jacques J.M. van Dongen Leiden University Medical Center
Leonore A. Herzenberg
Leonore A. Herzenberg Stanford University
Willem E. Fibbe
Willem E. Fibbe Leiden University Medical Center
Anton W. Langerak
Anton W. Langerak Erasmus University Rotterdam
Marcel J. T. Reinders
Marcel J. T. Reinders Delft University of Technology
Leonard A. Herzenberg
Leonard A. Herzenberg Stanford University
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Adrian J. Thrasher
Adrian J. Thrasher University College London
Mario Roederer
Mario Roederer National Institute of Allergy and Infectious Diseases
Arjan C. Lankester
Arjan C. Lankester Leiden University Medical Center

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