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Immunology

D-Index
119
Citations
58471
World Ranking
340
National Ranking
11

Medicine

D-Index
120
Citations
59295
World Ranking
3718
National Ranking
144

Overview

Jacques J.M. van Dongen is affiliated with Leiden University Medical Center in the Netherlands, with a research focus primarily in Medicine and Immunology and Microbiology. Their work spans various subfields such as Immunology, Molecular Biology, Hematology, Genetics, and Oncology, highlighting a multidisciplinary approach to biomedical science.

The scientist's research covers several main topics, including:

  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Immunodeficiency and Autoimmune Disorders
  • Lymphoma Diagnosis and Treatment
  • Single-cell and Spatial Transcriptomics
  • Chronic Lymphocytic Leukemia Research
  • Acute Lymphoblastic Leukemia Research

Jacques J.M. van Dongen has contributed to multiple scientific papers across leading journals. Selected recent publications include:

  • Prolonged activation of nasal immune cell populations and development of tissue-resident SARS-CoV-2-specific CD8+ T cell responses following COVID-19, 2021, published in Nature Immunology
  • Single-cell immune profiling reveals thymus-seeding populations, T cell commitment, and multilineage development in the human thymus, 2022, published in Science Immunology
  • Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID, 2020, published in Molecular Therapy - Methods & Clinical Development
  • Age Distribution of Multiple Functionally Relevant Subsets of CD4+ T Cells in Human Blood Using a Standardized and Validated 14-Color EuroFlow Immune Monitoring Tube, 2020, published in Frontiers in Immunology
  • Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective, 2020, published in Frontiers in Immunology

The scientist collaborates extensively with fellow researchers, with frequent co-authors including Alberto Órfão, Cristina Teodósio, Vincent H. J. van der Velden, Magdalena A. Berkowska, and Martín Pérez-Andrés.

The venues where Jacques J.M. van Dongen most frequently publishes are:

  • Frontiers in Immunology
  • Cancers
  • bioRxiv (Cold Spring Harbor Laboratory)
  • HemaSphere
  • Blood

Best Publications

  • Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.

    J J M van Dongen;A W Langerak;M Brüggemann;P A S Evans

  • Standardization and quality control studies of ‘real-time’ quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – A Europe Against Cancer Program

    J Gabert;E Beillard;V H J van der Velden;W Bi

  • Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia.

    van Dongen Jj;Macintyre Ea;Gabert Ja;Delabesse E

  • Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program

    E Beillard;N Pallisgaard;V H J van der Velden;W Bi

  • Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood

    Jacques Jm van Dongen;Taku Seriu;E Renate Panzer-Grümayer;Andrea Biondi

  • EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes.

    J J M van Dongen;L Lhermitte;S Böttcher;J Almeida

  • Immunophenotyping of blood lymphocytes in childhood: Reference values for lymphocyte subpopulations

    W.Marieke Comans-Bitter;Ronald de Groot;René van den Beemd;Herman J. Neijens

  • Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study

    Valentino Conter;Claus R. Bartram;Maria Grazia Valsecchi;Andre Schrauder

  • EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols

    T Kalina;J Flores-Montero;V H J van der Velden;M Martin-Ayuso

  • Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.

    V H J van der Velden;G Cazzaniga;A Schrauder;J Hancock

  • Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects.

    V H J van der Velden;A Hochhaus;G Cazzaniga;T Szczepanski

  • Next Generation Flow for highly sensitive and standardized detection of minimal residual disease in multiple myeloma

    J Flores-Montero;L Sanoja-Flores;B Paiva;N Puig

  • An antibody-deficiency syndrome due to mutations in the CD19 gene

    Menno C van Zelm;Ismail Reisli;Mirjam van der Burg;Diana Castaño

  • Minimal residual disease diagnostics in acute lymphoblastic leukemia: need for sensitive, fast, and standardized technologies

    Jacques J. M. van Dongen;Vincent H. J. van der Velden;Monika Brüggemann;Alberto Orfao

  • EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

    A. W. Langerak;P. J. T. A. Groenen;M. Brüggemann;K. Beldjord

  • Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study

    Martin Schrappe;Maria Grazia Valsecchi;Claus R. Bartram;André Schrauder

  • Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence

    Richard A. Larson;Eric L. Sievers;Eric L. Sievers;Edward A. Stadtmauer;Bob Löwenberg

  • Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia.

    T Flohr;T Flohr;A Schrauder;G Cazzaniga;R Panzer-Grümayer

  • New insights to the MLL recombinome of acute leukemias

    C. Meyer;E. Kowarz;J. Hofmann;A. Renneville

  • The MLL recombinome of acute leukemias.

    C. Meyer;B. Schneider;S. Jakob;S. Strehl

  • Proposals for immunological classification of acute leukemias

    J. J. M. Van Dongen

Frequent Co-Authors

Alberto Orfao
Alberto Orfao University of Salamanca
Mirjam van der Burg
Mirjam van der Burg Erasmus University Rotterdam
Anton W. Langerak
Anton W. Langerak Erasmus University Rotterdam
Menno C. van Zelm
Menno C. van Zelm Monash University
Frank J.T. Staal
Frank J.T. Staal Leiden University Medical Center
Julia Almeida
Julia Almeida University of Salamanca
Dik C. van Gent
Dik C. van Gent Erasmus University Rotterdam
Arjan C. Lankester
Arjan C. Lankester Leiden University Medical Center
Herbert Hooijkaas
Herbert Hooijkaas Erasmus University Rotterdam
Maria-Victoria Mateos
Maria-Victoria Mateos University of Salamanca

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