2026 Dan R. Littman: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Best Scientists	180	609	560	383	345	455	151723
Immunology	179	38	35	27	25	435	156729
Medicine	180	366	333	229	206	446	157341

Research.com Recognitions

2026 - Research.com Immunology in United States Leader Award
2025 - Research.com Best Scientists Award
2025 - Research.com Immunology in United States Leader Award
2022 - Research.com Microbiology in United States Leader Award
2019 - Distinguished Fellows of the American Association of Immunologists (AAI)
2012 - Member of the National Academy of Medicine (NAM)
2004 - Member of the National Academy of Sciences
2003 - Fellow of the American Academy of Arts and Sciences
Member of the Association of American Physicians
Member of the Association of American Physicians
Member of the Association of American Physicians
Member of the Association of American Physicians
Member of the Association of American Physicians

Overview

Dan R. Littman is affiliated with New York University in the United States and has an extensive publication record in the fields of immunology, microbiology, and medicine. Their research primarily focuses on immune cell function, microbial interactions in the gut, and molecular mechanisms underlying immune responses.

The scientist's work covers a range of main topics, including:

Immune Cell Function and Interaction
IL-33, ST2, and ILC Pathways
T-cell and B-cell Immunology
Gut microbiota and health
Clostridium difficile and Clostridium perfringens research
SARS-CoV-2 and COVID-19 Research
Single-cell and spatial transcriptomics

Dan R. Littman has published extensively in prominent journals. Frequent publication venues include:

bioRxiv (Cold Spring Harbor Laboratory)
Nature
Cell Reports
Cell
UNC Libraries

Some recent representative publications are:

"Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians" (2021, Nature)
"Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier" (2020, Nature)
"A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation" (2022, Nature)
"TH17 cell heterogeneity and its role in tissue inflammation" (2023, Nature Immunology)
"Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia" (2022, Nature Communications)

Their frequent co-authors include:

Lina Kroehling
Jhimmy Talbot
Yuhan Hao
Maria Pokrovskii
Rabi Upadhyay

Dan R. Littman's research spans several subfields, including:

Immunology
Molecular Biology
Infectious Diseases
Oncology
Hematology

The scientist's work has been recognized with membership and fellowships in notable organizations:

Distinguished Fellow of the American Association of Immunologists (AAI), 2019
Member of the National Academy of Medicine (NAM), 2012
Member of the National Academy of Sciences, 2004
Fellow of the American Academy of Arts and Sciences, 2003
Member of the Association of American Physicians

Best Publications

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

Ivaylo I. Ivanov;Brent S. McKenzie;Liang Zhou;Carlos E. Tadokoro

6624
Citations
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivaylo I. Ivanov;Koji Atarashi;Nicolas Manel;Eoin L. Brodie

5065
Citations
Identification of a major co-receptor for primary isolates of HIV-1

H Deng;R Liu;W Ellmeier;S Choe

4984
Citations
Interactions between the microbiota and the immune system.

Lora V. Hooper;Dan R. Littman;Andrew J. Macpherson

4724
Citations
ATP mediates rapid microglial response to local brain injury in vivo

Dimitrios Davalos;Jaime Grutzendler;Jaime Grutzendler;Guang Yang;Jiyun V Kim

4517
Citations
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Frederic Geissmann;Steffen Jung;Dan R. Littman

4189
Citations
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

T.B.H. Geijtenbeek;D.S. Kwon;R. Torensma;S.J. van Vliet

3279
Citations
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

Yong-Rui Zou;Andreas H. Kottmann;Masahiko Kuroda;Ichiro Taniuchi

3096
Citations
Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.

Steffen Jung;Julio Aliberti;Petra Graemmel;Mary Jean Sunshine

2948
Citations
Signal transduction by lymphocyte antigen receptors

Arthur Weiss;Dan R. Littman

2815
Citations
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

Christopher N. Parkhurst;Guang Yang;Ipe Ninan;Jeffrey N. Savas

2798
Citations
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.

Liang Zhou;Ivaylo I Ivanov;Rosanne Spolski;Roy Min

2685
Citations
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.

Liang Zhou;Jared E. Lopes;Jared E. Lopes;Mark M. W. Chong;Ivaylo I. Ivanov

2648
Citations
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

Jose U Scher;Andrew Sczesnak;Andrew Sczesnak;Randy S Longman;Randy S Longman;Nicola Segata;Nicola Segata

2150
Citations
In Vivo Depletion of CD11c+ Dendritic Cells Abrogates Priming of CD8+ T Cells by Exogenous Cell-Associated Antigens

Steffen Jung;Derya Unutmaz;Phillip Wong;Gen Ichiro Sano

2140
Citations
The microbiota in adaptive immune homeostasis and disease

Kenya Honda;Dan R. Littman

2111
Citations
Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivaylo Ivanov Ivanov;Rosa de Llanos Frutos;Nicolas Manel;Keiji Yoshinaga

2027
Citations
Plasticity of CD4+ T Cell Lineage Differentiation

Liang Zhou;Mark M.W. Chong;Dan R. Littman

1997
Citations
CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

Jan Hendrik Niess;Stephan Brand;Xiubin Gu;Limor Landsman

1935
Citations
Sparse and Compositionally Robust Inference of Microbial Ecological Networks

Zachary D. Kurtz;Christian L. Müller;Emily R. Miraldi;Dan R. Littman

1764
Citations
The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat.

Nicolas Manel;Derya Unutmaz;Dan R Littman

1743
Citations

Frequent Co-Authors

Richard Bonneau New York University

Nigel Killeen University of California, San Francisco

Vineet N. KewalRamani National Institutes of Health

Nicolas Manel PSL University

Ichiro Taniuchi RIKEN Center for Integrative Medical Sciences

Derya Unutmaz University of Connecticut

Steffen Jung Weizmann Institute of Science

Wilfried Ellmeier Medical University of Vienna

Eric G. Pamer Memorial Sloan Kettering Cancer Center

Curtis Huttenhower Harvard University

External Links

Personal website of Dan R. Littman

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