John O. Trent

Overview

Best Publications

• Discovery and Development of the G-rich Oligonucleotide AS1411 as a Novel Treatment for Cancer

  Paula J. Bates;Damian A. Laber;Donald M. Miller;Shelia D. Thomas

  1114
  Citations

• Inhibition of human telomerase by a G-quadruplex-interactive compound.

  Daekyu Sun;Brian Thompson;Brian E. Cathers;Miguel Salazar

  1061
  Citations

• Stability and kinetics of G-quadruplex structures

  Andrew N. Lane;J. Brad Chaires;Robert D. Gray;John O. Trent

  859
  Citations

• Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding *

  Paula J. Bates;Jasbir B. Kahlon;Shelia D. Thomas;John O. Trent

  605
  Citations

• G-Quadruplex Secondary Structure Obtained from Circular Dichroism Spectroscopy.

  Rafael del Villar-Guerra;John O. Trent;Jonathan B. Chaires

  533
  Citations

• Biophysical and biological properties of quadruplex oligodeoxyribonucleotides.

  Virna Đapić;Vedra Abdomerović;Rachel Marrington;Jemma Peberdy

  483
  Citations

• Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

  Brian Clem;Sucheta Telang;Amy Clem;Abdullah Yalcin

  477
  Citations

• Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal

  Jing-Jing Li;John J. Correia;Lei Wang;John O. Trent

  414
  Citations

• G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms.

  Paula J. Bates;Elsa M. Reyes-Reyes;Mohammad T. Malik;Emily M. Murphy

  331
  Citations

• Intercalative G-Tetraplex Stabilization of Telomeric DNA by a Cationic Porphyrin1

  Ihtshamul Haq;John O. Trent;and Babur Z. Chowdhry;Terence C. Jenkins

  314
  Citations

• Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

  Brian F. Clem;Julie O'Neal;Gilles Tapolsky;Amy L. Clem

  312
  Citations

• Molecular‐Size Reduction of a Potent CXCR4‐Chemokine Antagonist Using Orthogonal Combination of Conformation‐ and Sequence‐Based Libraries

  Nobutaka Fujii;Shinya Oishi;Kenichi Hiramatsu;Takanobu Araki

  292
  Citations

• Hydration is a major determinant of the G-quadruplex stability and conformation of the human telomere 3' sequence of d(AG3(TTAG3)3).

  M. Clarke Miller;Robert Buscaglia;Jonathan B. Chaires;Andrew N. Lane

  290
  Citations

• Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex.

  Patrick A. Holt;Jonathan B. Chaires;John O. Trent

  283
  Citations

• Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor–coactivator interactions

  Anne-Marie Leduc;John O. Trent;James L. Wittliff;Kelli S. Bramlett

  280
  Citations

• Both Hepatocyte Growth Factor (HGF) and Stromal-Derived Factor-1 Regulate the Metastatic Behavior of Human Rhabdomyosarcoma Cells, But Only HGF Enhances Their Resistance to Radiochemotherapy

  Kacper Jankowski;Magda Kucia;Marcin Wysoczynski;Ryan Reca

  265
  Citations

• Folding and unfolding pathways of the human telomeric G-quadruplex.

  Robert D. Gray;John O. Trent;Jonathan B. Chaires

  255
  Citations

• Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides.

  Xiaohua Xu;Fofi Hamhouyia;Shelia D. Thomas;Tom J. Burke

  231
  Citations

• Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-diones

  Philip J. Perry;Anthony P. Reszka;Alexis A. Wood;Martin A. Read

  227
  Citations

• Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence.

  Magdalena M. Dailey;M. Clarke Miller;Paula J. Bates;Andrew N. Lane

  200
  Citations