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Chemistry

D-Index
65
Citations
13442
World Ranking
7758
National Ranking
515

Biology and Biochemistry

D-Index
68
Citations
14057
World Ranking
7926
National Ranking
537

Overview

Akira Otaka is a researcher affiliated with the University of Tokushima in Japan, with significant contributions across biochemistry, genetics, molecular biology, medicine, and chemistry. Their body of work spans several specialized domains, particularly molecular biology and organic chemistry, with relevant applications in oncology and immunology.

The main fields of study that characterize Akira Otaka's research include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Chemistry

Subfields of focus involve:

  • Molecular Biology
  • Organic Chemistry
  • Oncology
  • Immunology
  • Biochemistry

Research topics frequently addressed by Otaka cover:

  • Chemical Synthesis and Analysis
  • Click Chemistry and Applications
  • Peptidase Inhibition and Analysis
  • Monoclonal and Polyclonal Antibodies Research
  • Sulfur-Based Synthesis Techniques
  • Lanthanide and Transition Metal Complexes
  • Receptor Mechanisms and Signaling

Otaka has published extensively, with recent papers including:

  • Peptide Cyclization Mediated by Metal-Free S-Arylation: S-Protected Cysteine Sulfoxide as an Umpolung of the Cysteine Nucleophile (2021, Chemistry - A European Journal)
  • Development of a 1,3a,6a-triazapentalene derivative as a compact and thiol-specific fluorescent labeling reagent (2020, Communications Chemistry)
  • Identification of Functional Domains of CXCL14 Involved in High-Affinity Binding and Intracellular Transport of CpG DNA (2021, The Journal of Immunology)
  • Sequence-Independent Traceless Method for Preparation of Peptide/Protein Thioesters Using CPaseY-Mediated Hydrazinolysis (2020, Chemical and Pharmaceutical Bulletin)
  • CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses (2023, Journal of Pharmacological Sciences)

Their research has appeared most frequently in the following venues:

  • Chemical and Pharmaceutical Bulletin
  • Chemistry - A European Journal
  • Communications Chemistry
  • Journal of Pharmacological Sciences
  • The Journal of Immunology

Frequent co-authors collaborating with Otaka include:

  • Masaya Denda
  • Akira Shigenaga
  • Daishiro Kobayashi
  • Yutaka Kohmura
  • Toshihiko Sugiki

Best Publications

  • Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats.

    Ryoya Oku;Masamichi Satoh;Nobutaka Fujii;Akira Otaka

  • A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

    Hirokazu Tamamura;Younong Xu;Toshio Hattori;Xiaoyan Zhang

  • T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer

    Hirokazu Tamamura;Akira Hori;Naoyuki Kanzaki;Kenichi Hiramatsu

  • Identification of cell binding sites in the laminin α1 chain carboxyl- terminal globular domain by systematic screening of synthetic peptides

    Motoyoshi Nomizu;Woo Ho Kim;Keizo Yamamura;Atsushi Utani

  • HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus.

    Norio Yamamoto;Rongge Yang;Yoshiyuki Yoshinaka;Shinji Amari

  • Molecular‐Size Reduction of a Potent CXCR4‐Chemokine Antagonist Using Orthogonal Combination of Conformation‐ and Sequence‐Based Libraries

    Nobutaka Fujii;Shinya Oishi;Kenichi Hiramatsu;Takanobu Araki

  • Nonhydrolyzable Phosphotyrosyl Mimetics for the Preparation Of Phosphatase-Resistant SH2 Domain Inhibitors

    Terrence R. Jr. Burke;Mark S. Smyth;Akira Otaka;Motoyoshi Nomizu

  • Preparation of fluoro- and hydroxy-4-(phosphonomethyl)-D,L-phenylalanine suitably protected for solid-phase synthesis of peptides containing hydrolytically stable analogs of O-phosphotyrosine

    Terrence R. Burke;Mark S. Smyth;Motoyoshi Nomizu;Akira Otaka

  • Cell Binding Sequences in Mouse Laminin α1 Chain

    Motoyoshi Nomizu;Yuichiro Kuratomi;Katherine M. Malinda;Sang-Yong Song

  • Remodeling of gp41‐C34 Peptide Leads to Highly Effective Inhibitors of the Fusion of HIV‐1 with Target Cells

    Akira Otaka;Miki Nakamura;Daisuke Nameki;Eiichi Kodama

  • A highly stereoselective synthesis of (E)-alkene dipeptide isosteres via organocyanocopper-Lewis acid mediated reaction

    Toshiro Ibuka;Hiromu Habashita;Akira Otaka;Nobutaka Fujii

  • Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

    Sang-Moon Yun;Tinoush Moulaei;Dan Lim;Jeong K. Bang

  • Possible involvement of the α1 isoform of 5′AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle

    Taro Toyoda;Tatsuya Hayashi;Licht Miyamoto;Shin Yonemitsu

  • A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II)

    Masao Masuda;Hideki Nakashima;Toshihiro Ueda;Hiroyasu Naba

  • Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent.

    Hirokazu Tamamura;Miho Fujisawa;Kenichi Hiramatsu;Makiko Mizumoto

  • Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes.

    Hirokazu Tamamura;Akane Omagari;Shinya Oishi;Taisei Kanamoto

  • New strategy for the chemical synthesis of proteins

    Haruaki Yajima;Nobutaka Fujii;Susumu Funakoshi;Toshihiro Watanabe

  • Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.

    Hirokazu Tamamura;Akane Omagari;Kenichi Hiramatsu;Kazuyo Gotoh

  • Identification of Cell Binding Sequences in Mouse Laminin γ1 Chain by Systematic Peptide Screening

    Motoyoshi Nomizu;Yuichiro Kuratomi;Sang-Yong Song;M. Lourdes Ponce

  • Why is phosphonodifluoromethyl phenylalanine a more potent inhibitory moiety than phosphonomethyl phenylalanine toward protein-tyrosine phosphatases?

    L. Chen;L. Wu;L. Wu;A. Otaka;M.S. Smyth

  • Chemical Synthesis of Biologically Active Monoglycosylated GM2‐Activator Protein Analogue Using N‐Sulfanylethylanilide Peptide

    Kohei Sato;Akira Shigenaga;Keisuke Kitakaze;Ken Sakamoto

Frequent Co-Authors

Nobutaka Fujii
Nobutaka Fujii Kyoto University
Hirokazu Tamamura
Hirokazu Tamamura Tokyo Medical and Dental University
Shinya Oishi
Shinya Oishi Kyoto University
Naoki Yamamoto
Naoki Yamamoto Kyoto University
Motoyoshi Nomizu
Motoyoshi Nomizu Tokyo University of Pharmacy and Life Sciences
Peter P. Roller
Peter P. Roller National Institutes of Health
Terrence R. Burke
Terrence R. Burke National Institutes of Health
Hiroaki Ohno
Hiroaki Ohno Kyoto University
Stephen C. Peiper
Stephen C. Peiper Thomas Jefferson University
Masao Matsuoka
Masao Matsuoka Kumamoto University

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