World's Best Scientists 2026 revealed!
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Best Female Scientists
2025
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Plant Science and Agronomy
USA
2026

D-Index & Metrics

Best Female Scientists

D-Index
136
Citations
68656
World Ranking
274
National Ranking
172

Plant Science and Agronomy

D-Index
120
Citations
60740
World Ranking
66
National Ranking
19

Research.com Recognitions

  • 2026 - Research.com Plant Science and Agronomy in United States Leader Award
  • 2025 - Research.com Best Female Scientists Award
  • 2025 - Research.com Plant Science and Agronomy in United States Leader Award
  • 2022 - Dr. Gertrude Herzfeld International Jewish Woman of the Year Prize for Health
  • 2009 - Abraham White Lifetime Achievement in Science Award
  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1999 - Association for Women in Science Mentoring Award
  • 1993 - WISE Award, Women in Science and Engineering
  • 1992 - Debio-Pharm Peptide Award
  • 1991 - Senior Women in Science Award, American Society Cell Biology
  • 1987 - Hildegard Doerenkamp-Gerhard Zbinden Foundation Scientific Award
  • 1984 - NIH Director's Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Internal medicine

Hynda K. Kleinman focuses on Cell biology, Laminin, Basement membrane, Biochemistry and Angiogenesis. His Cell biology research includes themes of Vascular endothelial growth factor C, Vascular endothelial growth factor B, Growth factor and Cellular differentiation. His Laminin study combines topics in areas such as Molecular biology, Peptide sequence, Cell adhesion and Pentapeptide repeat, Peptide.

The Basement membrane study combines topics in areas such as Perlecan, Extracellular matrix, Collagen, type I, alpha 1, Type IV collagen and Matrix. Hynda K. Kleinman interconnects Endothelial stem cell, Vascular endothelial growth factor A and Cell migration in the investigation of issues within Angiogenesis. His Matrigel study combines topics from a wide range of disciplines, such as Immunology and Pathology.

His most cited work include:

  • A Rapid in Vitro Assay for Quantitating the Invasive Potential of Tumor Cells (1691 citations)
  • Basement Membrane Complexes with Biological Activity (1358 citations)
  • Role of collagenous matrices in the adhesion and growth of cells. (1227 citations)

What are the main themes of his work throughout his whole career to date?

Hynda K. Kleinman spends much of his time researching Laminin, Cell biology, Basement membrane, Biochemistry and Molecular biology. His biological study spans a wide range of topics, including Fibronectin, Cell culture, Cell adhesion and Peptide. His work carried out in the field of Cell biology brings together such families of science as Cellular differentiation, Angiogenesis, Matrigel and Endocrinology.

The study incorporates disciplines such as Endothelial stem cell, Tube formation and Wound healing, Immunology in addition to Angiogenesis. His work investigates the relationship between Basement membrane and topics such as In vitro that intersect with problems in In vivo. His Molecular biology study integrates concerns from other disciplines, such as Receptor, Antibody, Gene expression and Collagenase.

He most often published in these fields:

  • Laminin (45.15%)
  • Cell biology (38.50%)
  • Basement membrane (27.42%)

What were the highlights of his more recent work (between 2004-2020)?

  • Cell biology (38.50%)
  • Extracellular matrix (18.28%)
  • Angiogenesis (21.88%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Cell biology, Extracellular matrix, Angiogenesis, Pathology and Cancer research. The various areas that Hynda K. Kleinman examines in his Cell biology study include Endothelial stem cell and Cell adhesion. His Extracellular matrix research includes elements of Extracellular, Cell, Matrigel and Cellular differentiation.

His Angiogenesis research integrates issues from Cell migration, Wound healing, Vasculogenesis, Molecular biology and Tube formation. His Cancer research study incorporates themes from Tumor progression, Mesenchymal stem cell and Cell growth. His Laminin research is multidisciplinary, incorporating perspectives in Receptor, EGF-like domain and In vivo.

Between 2004 and 2020, his most popular works were:

  • Matrigel: basement membrane matrix with biological activity. (1031 citations)
  • A simplified laminin nomenclature (681 citations)
  • In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract (436 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

His main research concerns Cell biology, Extracellular matrix, Matrigel, Basement membrane and Pathology. Hynda K. Kleinman has researched Cell biology in several fields, including Endothelial stem cell, Cell culture and Angiogenesis. He mostly deals with Laminin in his studies of Extracellular matrix.

His study on Laminin is mostly dedicated to connecting different topics, such as EGF-like domain. Hynda K. Kleinman works mostly in the field of Matrigel, limiting it down to topics relating to Cellular differentiation and, in certain cases, Matrix, In vivo, Mesoderm and Molecular biology, as a part of the same area of interest. His Basement membrane research is multidisciplinary, relying on both Tissue engineering, Biomedical engineering, Granulation tissue and Fibrin glue.

Best Publications

  • Role of collagenous matrices in the adhesion and growth of cells.

    H K Kleinman;R J Klebe;G R Martin

  • Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

    Erin G. Schuetz;Donna Li;Curtis J. Omiecinski;Ursula Muller‐Eberhard

  • Platelet‐derived growth factor is a chemoattractant for vascular smooth muscle cells

    G. R. Grotendorst;T. Chang;H. E. J. Seppä;H. K. Kleinman

  • Type IV collagenase(s) and TIMPs modulate endothelial cell morphogenesis in vitro

    H. William Schnaper;H. William Schnaper;Derrick S. Grant;William G. Stetler-Stevenson;Rafael Fridman

  • Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo.

    Derrick S. Grant;James L. Kinsella;Rafael Fridman;Robert Auerbach

  • Complex Extracellular Matrices Promote Tissue-Specific Stem Cell Differentiation

    Deborah Philp;Silvia S. Chen;Wendy Fitzgerald;Jan Orenstein

  • Advancing science and technology via 3D culture on basement membrane matrix.

    G. Benton;J. George;H.K. Kleinman;I.P. Arnaoutova

  • Intracellular mechanisms involved in basement membrane induced blood vessel differentiation in vitro.

    Derrick S. Grant;Peter I. Lelkes;Katsunori Fukuda;Hynda K. Kleinman

  • The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro

    Paul M.J. Clement;Hartmut M. Hanauske-Abel;Edith C. Wolff;Hynda K. Kleinman

  • The RGD containing site of the mouse laminin A chain is active for cell attachment, spreading, migration and neurite outgrowth.

    Ken-Ichiro Tashiro;Gregory C. Sephel;Dave Greatorex;Makoto Sasaki

  • Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fc-mediated phagocytosis by cultured human macrophages

    J F Bohnsack;H K Kleinman;T Takahashi;J J O'Shea

  • The influence of extracellular matrix on the generation of vascularized, engineered, transplantable tissue.

    Oliver C.S. Cassell;Wayne A. Morrison;Aurora Messina;Anthony J. Penington

  • Plasminogen activators augment endothelial cell organization in vitro by two distinct pathways.

    H. William Schnaper;H. William Schnaper;Elliot S. Barnathan;Andrew Mazar;Shailendra Maheshwari

  • Regulation of cell attachment and cell number by fibronectin and laminin.

    Victor P. Terranova;Monique Aumailley;Leslie H. Sultan;George R. Martin

  • Tumor-Associated Macrophages as Targets for Cancer Therapy

    Larry M. Wahl;Hynda K. Kleinman

  • Effects of extracellular matrix components on the growth and differentiation of cultured rat hepatocytes.

    Norimasa Sawada;Akito Tomomura;Carol A. Sattler;Gerald L. Sattler

  • Differential effects of interferon gamma and alpha on in vitro model of angiogenesis

    R. K. Maheshwari;V. Srikantan;D. Bhartiya;H. K. Kleinman

  • The control of DNA synthesis in primary cultures of hepatocytes from adult and young rats: Interactions of extracellular matrix components, epidermal growth factor, and the cell cycle

    Akito Tomomura;Norimasa Sawada;Gerald L. Sattler;Hynda K. Kleinman

  • Growth of exocrine acinar cells on a reconstituted basement membrane gel.

    Constance Oliver;Judith F. Waters;Carolyn L. Tolbert;Hynda K. Kleinman

  • LAMININ SIKVAV PEPTIDE INDUCTION OF MONOCYTE/MACROPHAGE PROSTAGLANDIN E2 AND MATRIX METALLOPROTEINASES

    Marta L. Corcoran;Maura C. Kibbey;Hynda K. Kleinman;Larry M. Wahl

  • Human T lymphocytes synthesize the 92 kDa type IV collagenase (gelatinase B)

    Weeks Bs;Schnaper Hw;Handy M;Holloway E

Frequent Co-Authors

George R. Martin
George R. Martin Riptide Bioscience
Yoshihiko Yamada
Yoshihiko Yamada National Institutes of Health
Motoyoshi Nomizu
Motoyoshi Nomizu Tokyo University of Pharmacy and Life Sciences
Matthew P. Hoffman
Matthew P. Hoffman National Institutes of Health
Allan L. Goldstein
Allan L. Goldstein George Washington University
John R. Hassell
John R. Hassell University of South Florida
Martin Dym
Martin Dym Georgetown University Medical Center
Mathias Jucker
Mathias Jucker University of Tübingen
Maria C. Cid
Maria C. Cid University of Barcelona
Bruno Péault
Bruno Péault University of California, Los Angeles

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