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Biology and Biochemistry
Germany
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
162
Citations
80027
World Ranking
119
National Ranking
7

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Germany Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Biochemistry

His primary areas of study are Biochemistry, Laminin, Molecular biology, Basement membrane and Cell biology. Much of his study explores Biochemistry relationship to Biophysics. The study incorporates disciplines such as Protein structure, Fibronectin and Integrin in addition to Laminin.

He has researched Molecular biology in several fields, including Epitope, Cell culture, Mesenchyme and Immunofluorescence. His Basement membrane study incorporates themes from Membrane, Membrane protein, Morphogenesis, Matrix and 7S Collagen. His Cell biology research is multidisciplinary, relying on both Binding protein and Polyclonal antibodies.

His most cited work include:

  • Laminin and Other Basement Membrane Components (795 citations)
  • A Network Model for the Organization of Type IV Collagen Molecules in Basement Membranes (763 citations)
  • A new nomenclature for the laminins. (668 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Biochemistry, Molecular biology, Laminin, Basement membrane and Cell biology. Rupert Timpl regularly ties together related areas like Biophysics in his Biochemistry studies. His Molecular biology research is multidisciplinary, incorporating elements of Epitope, Antibody, Antigen and Cell culture.

His research in Laminin focuses on subjects like Fibronectin, which are connected to Matrix. Rupert Timpl interconnects Membrane, Membrane protein and Type IV collagen in the investigation of issues within Basement membrane. The concepts of his Binding site study are interwoven with issues in Peptide sequence and Plasma protein binding.

He most often published in these fields:

  • Biochemistry (49.34%)
  • Molecular biology (35.02%)
  • Laminin (28.63%)

What were the highlights of his more recent work (between 1998-2018)?

  • Biochemistry (49.34%)
  • Cell biology (18.28%)
  • Laminin (28.63%)

In recent papers he was focusing on the following fields of study:

Rupert Timpl mainly investigates Biochemistry, Cell biology, Laminin, Basement membrane and Extracellular matrix. His research combines Biophysics and Biochemistry. His Cell biology study integrates concerns from other disciplines, such as Angiogenesis, Endostatin and Cell adhesion.

His Laminin research includes themes of Molecular biology and Integrin. His Basement membrane study combines topics from a wide range of disciplines, such as Phenotype, Immunogold labelling, Antibody and Nidogen-2. His work deals with themes such as Cell culture and Pathology, which intersect with Extracellular matrix.

Between 1998 and 2018, his most popular works were:

  • Endostatin inhibits VEGF‐induced endothelial cell migration and tumor growth independently of zinc binding (419 citations)
  • Binding of the G domains of laminin α1 and α2 chains and perlecan to heparin, sulfatides, α‐dystroglycan and several extracellular matrix proteins (414 citations)
  • Fibulins: a versatile family of extracellular matrix proteins (341 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Amino acid

Rupert Timpl mainly focuses on Biochemistry, Laminin, Extracellular matrix, Cell biology and Binding site. Many of his studies involve connections with topics such as Biophysics and Biochemistry. His Laminin study combines topics in areas such as Perlecan, Transfection, Glycoprotein and Recombinant DNA.

His biological study spans a wide range of topics, including Glycolipid, Molecular biology and Basement membrane, Pathology. In the subject of general Cell biology, his work in Lectican, Brevican and Neurocan is often linked to CD69, thereby combining diverse domains of study. His Binding site research includes elements of Protein structure and Heparan sulfate, Heparin.

Best Publications

  • Laminin--a glycoprotein from basement membranes.

    R Timpl;H Rohde;P G Robey;S I Rennard

  • Structure and biological activity of basement membrane proteins

    Rupert Timpl

  • Laminin and Other Basement Membrane Components

    George R. Martin;Rupert Timpl

  • A Network Model for the Organization of Type IV Collagen Molecules in Basement Membranes

    Rupert Timpl;Hanna Wiedemann;Vera Van Delden;Heinz Furthmayr

  • Supramolecular assembly of basement membranes

    Rupert Timpl;Judith C. Brown

  • Macromolecular organization of basement membranes

    Rupert Timpl

  • Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix.

    Jürgen Engel;Erich Odermatt;Andreas Engel;Joseph A. Madri

  • A new nomenclature for the laminins.

    Robert E. Burgeson;Matthias Chiquet;Rainer Deutzmann;Peter Ekblom

  • The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival.

    D Edgar;R Timpl;H Thoenen

  • Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes

    Mercedes Costell;Erika Gustafsson;Attila Aszódi;Matthias Mörgelin

  • Arg‐Gly‐Asp constrained within cyclic pentapoptides Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1

    Monique Aumailley;Marion Gurrath;Gerhard Müller;Juan Calvete

  • Characterization of collagen peptides by sodium dodecylsulfate-polyacrylamide electrophoresis

    H. Furthmayr;R. Timpl

  • Selective recognition of cyclic RGD peptides of NMR defined conformation by alpha IIb beta 3, alpha V beta 3, and alpha 5 beta 1 integrins.

    M Pfaff;K Tangemann;B Müller;M Gurrath

  • Role of laminin a chain in the development of epithelial cell polarity

    Gerd Klein;Maria Langegger;Rupert Timpl;Peter Ekblom

  • The J1 glycoprotein--a novel nervous system cell adhesion molecule of the L2/HNK-1 family.

    Jan Kruse;Gerhard Keilhauer;Andreas Faissner;Rupert Timpl

  • Fibulins: a versatile family of extracellular matrix proteins

    Rupert Timpl;Takako Sasaki;Günter Kostka;Mon-Li Chu

  • Radioimmunoassay for type III procollagen peptide and its application to human liver disease.

    Heilwig Rohde;Ling Vargas;Heinrich Kalbfleisch;Miguel Bruguera

  • Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding

    Noriko Yamaguchi;Bela Anand-Apte;Margaret Lee;Takako Sasaki

  • Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.

    A. Sonnenberg;C. J. T. Linders;P. W. Modderman;C. H. Damsky

  • Membrane‐Type Matrix Metalloproteinases 1 and 2 Exhibit Broad‐Spectrum Proteolytic Capacities Comparable to Many Matrix Metalloproteinases

    Marie‐Pia D'ortho;Horst Will;Susan Atkinson;Georgina Butler

Frequent Co-Authors

Takako Sasaki
Takako Sasaki Oita University
Karlheinz Mann
Karlheinz Mann Max Planck Society
Mon-Li Chu
Mon-Li Chu Thomas Jefferson University
Jürgen Engel
Jürgen Engel University of Basel
Ulrike Mayer
Ulrike Mayer University of East Anglia
Erhard Hohenester
Erhard Hohenester Imperial College London
Klaus Kühn
Klaus Kühn Max Planck Society
Peter Ekblom
Peter Ekblom Lund University
Georg Wick
Georg Wick Innsbruck Medical University
Antti Vaheri
Antti Vaheri University of Helsinki

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