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Biology and Biochemistry

D-Index
64
Citations
13226
World Ranking
9775
National Ranking
747

Overview

Erhard Hohenester is affiliated with Imperial College London in the United Kingdom, focusing on research within the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their work spans several subfields including Cell Biology, Molecular Biology, Organic Chemistry, Immunology and Allergy, and Genetics.

The main topics addressed in Hohenester's research include:

  • Proteoglycans and glycosaminoglycans research
  • Glycosylation and glycoproteins research
  • Carbohydrate chemistry and synthesis
  • Cell adhesion molecules research
  • Cellular mechanics and interactions
  • Connective tissue disorders research
  • RNA research and splicing

Recent publications demonstrate a focus on molecular and structural understanding of biological macromolecules and their functions. Notable papers include:

  • "Molecular mechanism of decision-making in glycosaminoglycan biosynthesis," 2023, Nature Communications
  • "Organization of the laminin polymer node," 2021, Matrix Biology
  • "Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity," 2023, Wellcome Open Research
  • "Two-step release of kinase autoinhibition in discoidin domain receptor 1," 2020, Proceedings of the National Academy of Sciences
  • "Aberrant splicing as potential modifier of the phenotype of junctional epidermolysis bullosa," 2020, Journal of the European Academy of Dermatology and Venereology

Hohenester has collaborated frequently with several researchers, including:

  • Douglas Sammon
  • Rhodri M. L. Morgan
  • Benjamin Schumann
  • David C. Briggs
  • Muyuan Niu

Their research has been published in prominent scientific venues such as Wellcome Open Research, Nature Communications, Matrix Biology, Proceedings of the National Academy of Sciences, and the Journal of the European Academy of Dermatology and Venereology.

Best Publications

  • A simplified laminin nomenclature

    Monique Aumailley;Leena Bruckner-Tuderman;William G. Carter;Rainer Deutzmann

  • Mammalian collagen receptors.

    Birgit Leitinger;Erhard Hohenester

  • Laminins in basement membrane assembly

    Erhard Hohenester;Peter D. Yurchenco

  • Structure and function of laminin LG modules.

    Rupert Timpl;Dominic Tisi;Jan F. Talts;Zeynep Andac

  • Structural Basis for Gas6-Axl Signalling.

    Takako Sasaki;Pjotr G Knyazev;Naomi J Clout;Yuri Cheburkin

  • Crystal structure of the angiogenesis inhibitor endostatin at 1.5 Å resolution

    Erhard Hohenester;Takako Sasaki;Björn R. Olsen;Rupert Timpl

  • Laminin: the crux of basement membrane assembly

    Takako Sasaki;Reinhard Fässler;Erhard Hohenester

  • The Crystal Structure of a Laminin G–like Module Reveals the Molecular Basis of α-Dystroglycan Binding to Laminins, Perlecan, and Agrin

    Erhard Hohenester;Dominic Tisi;Jan F. Talts;Rupert Timpl

  • Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin

    Takako Sasaki;Helena Larsson;Johan Kreuger;Markku Salmivirta

  • A propofol binding site on mammalian GABAA receptors identified by photolabeling.

    Grace M S Yip;Zi-Wei Chen;Christopher J Edge;Christopher J Edge;Edward H Smith

  • Amyloid P component. A critical review

    M B. Pepys;D. R. Booth;W. L. Hutchinson;J. R. Gallimore

  • Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity.

    Takako Sasaki;Helena Larsson;Dominic Tisi;Lena Claesson-Welsh

  • Domain structure and organisation in extracellular matrix proteins.

    Erhard Hohenester;Jürgen Engel

  • Dialkylglycine Decarboxylase Structure: Bifunctional Active Site and Alkali Metal Sites

    Michael D. Toney;Erhard Hohenester;Sandra W. Cowan;Johan N. Jansonius

  • Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.

    Szymon W. Manka;Federico Carafoli;Robert Visse;Dominique Bihan

  • Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium.

    P. Burkhard;G. S. Rao;E. Hohenester;E. Hohenester;K. D. Schnackerz

  • Structure of the C-terminal laminin G-like domain pair of the laminin α2 chain harbouring binding sites for α-dystroglycan and heparin

    Dominic Tisi;Jan F. Talts;Jan F. Talts;Rupert Timpl;Erhard Hohenester

  • Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen.

    Antonios D. Konitsiotis;Nicolas Raynal;Dominique Bihan;Erhard Hohenester

  • Zinc-dependent dimers observed in crystals of human endostatin

    Yuan-Hua Ding;Kashi Javaherian;Kin-Ming Lo;Rajiv Chopra

  • Limited Cleavage of Extracellular Matrix Protein BM-40 by Matrix Metalloproteinases Increases Its Affinity for Collagens

    Takako Sasaki;Walter Göhring;Karlheinz Mann;Patrik Maurer

Frequent Co-Authors

Rupert Timpl
Rupert Timpl Max Planck Society
Johan N. Jansonius
Johan N. Jansonius University of Basel
Takako Sasaki
Takako Sasaki Oita University
Richard W. Farndale
Richard W. Farndale University of Cambridge
Mark B. Pepys
Mark B. Pepys University College London
Avner Yayon
Avner Yayon Weizmann Institute of Science
Jürgen Engel
Jürgen Engel University of Basel
Peter D. Yurchenco
Peter D. Yurchenco Rutgers, The State University of New Jersey
Hans Peter Bächinger
Hans Peter Bächinger Oregon Health & Science University
Alain Chédotal
Alain Chédotal Institut de la Vision

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