D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 78 Citations 16,270 151 World Ranking 1067 National Ranking 14

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

Karl Tryggvason mostly deals with Cell biology, Molecular biology, Nephrin, Laminin and Podocyte. His Cell biology research incorporates elements of Membrane protein, Kidney, Immunology and Downregulation and upregulation. He has researched Molecular biology in several fields, including Complementary DNA, Type IV collagen, Cellular differentiation and In situ hybridization.

His Nephrin research integrates issues from Glomerulonephritis, Slit diaphragm, Podocin and Congenital nephrotic syndrome. The Slit diaphragm study which covers Pathology that intersects with Monoclonal. His Laminin research is multidisciplinary, incorporating perspectives in Cell culture, Integrin, Cell adhesion and Basement membrane.

His most cited work include:

  • The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. (415 citations)
  • Laminin-5 Is a Marker of Invading Cancer Cells in Some Human Carcinomas and Is Coexpressed with the Receptor for Urokinase Plasminogen Activator in Budding Cancer Cells in Colon Adenocarcinomas (368 citations)
  • Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation (363 citations)

What are the main themes of his work throughout his whole career to date?

Karl Tryggvason mainly investigates Molecular biology, Cell biology, Laminin, Nephrin and Genetics. In Molecular biology, he works on issues like Complementary DNA, which are connected to Southern blot. The various areas that Karl Tryggvason examines in his Cell biology study include Endothelial stem cell, Membrane protein, Immunology and Cytoskeleton.

His research investigates the link between Laminin and topics such as Integrin that cross with problems in Cell migration. His Nephrin research includes themes of Slit diaphragm and Congenital nephrotic syndrome. In his work, Adenocarcinoma is strongly intertwined with Pathology, which is a subfield of Glomerulonephritis.

He most often published in these fields:

  • Molecular biology (37.15%)
  • Cell biology (31.94%)
  • Laminin (21.53%)

What were the highlights of his more recent work (between 2010-2021)?

  • Cell biology (31.94%)
  • Podocyte (18.06%)
  • Laminin (21.53%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cell biology, Podocyte, Laminin, Molecular biology and Genetics. His research integrates issues of Podocyte foot, Cell, Cytoskeleton and In vivo in his study of Cell biology. As a part of the same scientific family, Karl Tryggvason mostly works in the field of Podocyte, focusing on Zebrafish and, on occasion, Glomerulus and Embryogenesis.

Karl Tryggvason has included themes like Cell culture, Integrin, Host, Transplantation and Gene isoform in his Laminin study. His Molecular biology study combines topics from a wide range of disciplines, such as Nucleic acid, Expression vector, Receptor, CD31 and Extracellular matrix. His study in Slit diaphragm and Nephrin is done as part of Endocrinology.

Between 2010 and 2021, his most popular works were:

  • Functional Diversity of Laminins (209 citations)
  • Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment (190 citations)
  • Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria (127 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

Karl Tryggvason focuses on Cell biology, Podocyte, Laminin, Receptor and Molecular biology. The Gastrulation research he does as part of his general Cell biology study is frequently linked to other disciplines of science, such as Pyrin domain, therefore creating a link between diverse domains of science. In his study, Pathology, Renal glomerulus, Podocin, Glomerulus and Podocyte foot is inextricably linked to Zebrafish, which falls within the broad field of Podocyte.

His Laminin study combines topics in areas such as Cell culture, Integrin, Filopodia, Notch signaling pathway and Gene isoform. His Receptor study integrates concerns from other disciplines, such as Extracellular matrix and Intracellular. The concepts of his Molecular biology study are interwoven with issues in Bone growth, Downregulation and upregulation, Matrix metalloproteinase and Ectodomain.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.

Ganka Nikolova;Normund Jabs;Irena Konstantinova;Anna Domogatskaya.
Developmental Cell (2006)

640 Citations

Laminin-5 Is a Marker of Invading Cancer Cells in Some Human Carcinomas and Is Coexpressed with the Receptor for Urokinase Plasminogen Activator in Budding Cancer Cells in Colon Adenocarcinomas

Charles Pyke;Sirpa Salo;Elisabeth Ralfkiær;John Rømer.
Cancer Research (1995)

564 Citations

Structure of the Gene for Congenital Nephrotic Syndrome of the Finnish Type (NPHS1) and Characterization of Mutations

Ulla Lenkkeri;Minna Männikkö;Paula McCready;Jane Lamerdin.
American Journal of Human Genetics (1999)

518 Citations

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

Ignacio Varela;Juan Cadiñanos;Alberto M. Pendás;Ana Gutiérrez-Fernández.
Nature (2005)

488 Citations

Localization of Messenger RNA for Mr 72,000 and 92,000 Type IV Collagenases in Human Skin Cancers by in Situ Hybridization

Charles Pyke;Elisabeth Ralfkiær;Piricko Huhtala;Tina Hurskainen.
Cancer Research (1992)

472 Citations

Laminin isoforms in tumor invasion, angiogenesis and metastasis.

Manuel Patarroyo;Karl Tryggvason;Ismo Virtanen.
Seminars in Cancer Biology (2002)

422 Citations

Deletion of the Laminin α4 Chain Leads to Impaired Microvessel Maturation

Jill Thyboll;Jarkko Kortesmaa;Renhai Cao;Raija Soininen.
Molecular and Cellular Biology (2002)

412 Citations

The gamma 2 chain of kalinin/laminin 5 is preferentially expressed in invading malignant cells in human cancers.

C. Pyke;J. Rømer;P. Kallunki;L. R. Lund.
American Journal of Pathology (1994)

405 Citations

Messenger RNA for two type IV collagenases is located in stromal cells in human colon cancer

C. Pyke;E. Ralfkiaer;K. Tryggvason;K. Danø.
American Journal of Pathology (1993)

402 Citations

Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm.

Karl Tryggvason.
Journal of The American Society of Nephrology (1999)

374 Citations

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