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Harry Holthöfer

Harry Holthöfer

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
25048
World Ranking
8955
National Ranking
65

Overview

Harry Holthöfer is affiliated with the University of Helsinki in Finland and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their research spans a variety of specialized subfields, including molecular biology, cancer research, nephrology, pulmonary and respiratory medicine, and infectious diseases.

Their work covers multiple topics with a significant focus on extracellular vesicles and disease mechanisms. Other notable research themes include microRNA in disease regulation, dialysis and renal disease management, viral infections and vectors, aortic aneurysm repair treatments, cancer-related molecular mechanisms, and inflammatory biomarkers in disease prognosis.

Holthöfer has published articles in several scientific venues. Frequent publication outlets include:

  • Journal of Extracellular Vesicles
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cardiovascular Medicine
  • iScience
  • Genes

Significant recent papers authored or co-authored by Holthöfer:

  • "Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles" (2021, Journal of Extracellular Vesicles)
  • "The future of Extracellular Vesicles as Theranostics - an ISEV meeting report" (2020, Journal of Extracellular Vesicles)
  • "Comparison of urinary extracellular vesicle isolation methods for transcriptomic biomarker research in diabetic kidney disease" (2020, Journal of Extracellular Vesicles)
  • "Urinary extracellular vesicles: Assessment of pre-analytical variables and development of a quality control with focus on transcriptomic biomarker research" (2021, Journal of Extracellular Vesicles)
  • "Thrombosis and Inflammation-A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C" (2022, Frontiers in Cardiovascular Medicine)

Holthöfer has collaborated frequently with a number of co-authors, including:

  • Karina Barreiro
  • Maija Puhka
  • Om Prakash Dwivedi
  • Per-Henrik Groop
  • Jaakko Tuomilehto

The primary focus of Holthöfer's research revolves around extracellular vesicles and their role in disease, particularly in urinary biomarkers and kidney-related conditions. Their work also integrates aspects of molecular biology techniques and biomarker discovery relevant to clinical applications.

Best Publications

  • Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

    Clotilde Théry;Kenneth W. Witwer;Elena Aikawa;Maria Jose Alcaraz

  • Ulex europaeus I lectin as a marker for vascular endothelium in human tissues.

    H Holthöfer;I Virtanen;A L Kariniemi;M Hormia

  • Cellular origin and differentiation of renal carcinomas. A fluorescence microscopic study with kidney-specific antibodies, antiintermediate filament antibodies, and lectins.

    Holthöfer H;Miettinen A;Paasivuo R;Lehto Vp

  • Nephrin localizes to the slit pore of the glomerular epithelial cell.

    Lawrence B. Holzman;Patricia L.S.T. John;Iulia A. Kovari;Rakesh Verma

  • Expression of vimentin and cytokeratin types of intermediate filament proteins in developing and adult human kidneys.

    Holthöfer H;Miettinen A;Lehto Vp;Lehtonen E

  • Urinary extracellular vesicles : A position paper by the Urine Task Force of the International Society for Extracellular Vesicles

    Uta Erdbrügger;Charles J. Blijdorp;Irene V. Bijnsdorp;Francesc E. Borràs

  • Proteinuria and the expression of the podocyte slit diaphragm protein, nephrin, in diabetic nephropathy: effects of angiotensin converting enzyme inhibition.

    Robyn G Langham;Darren J Kelly;Alison J Cox;Napier M Thomson

  • Ulex Europaeus I Lectin as a Marker for Tumors Derived From Endothelial Cells

    M. Miettinen;H. Holthofer;V.-P. Lehto;A. Miettinen

  • Nephrin localizes at the podocyte filtration slit area and is characteristically spliced in the human kidney.

    Harry Holthöfer;Heikki Ahola;Marja Liisa Solin;Shixuan Wang

  • Lectins as fluorescence microscopic markers for saccharides in the human kidney.

    H Holthöfer;I Virtanen;E Pettersson;T Törnroth

  • Cytokines, Adhesion Molecules, and Cellular Infiltration in Nephropathia Epidemica Kidneys: An Immunohistochemical Study

    Mari Temonen;Jukka Mustonen;Heikki Helin;Amos Pasternack

  • Involvement of Lipid Rafts in Nephrin Phosphorylation and Organization of the Glomerular Slit Diaphragm

    Matias Simons;Karin Schwarz;Wilhelm Kriz;Aaro Miettinen

  • Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy.

    Petri Aaltonen;Pauliina Luimula;Eva Åström;Tuula Palmen

  • Nephrin in experimental glomerular disease.

    Pauliina Luimula;Heikki Ahola;Shi Xuan Wang;Marja Liisa Solin

  • Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study)

    F. M. van der Kloet;F. W.A. Tempels;N. Ismail;R. van der Heijden

  • Expression of the slit‐diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti‐proteinuric therapies

    Darren J. Kelly;Petri Aaltonen;Alison J. Cox;Jon R. Rumble

  • Binding characteristics of Escherichia coli adhesins in human urinary bladder.

    R Virkola;B Westerlund;H Holthöfer;J Parkkinen

  • Preparative Purification of Recombinant Proteins: Current Status and Future Trends

    Mayank Saraswat;Luca Musante;Alessandra Ravidá;Brian Shortt

  • Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell lines.

    Daniel Schiwek;Nicole Endlich;Nicole Endlich;Nicole Endlich;Lawrence Holzman;Lawrence Holzman;Lawrence Holzman;Harry Holthöfer;Harry Holthöfer;Harry Holthöfer

  • Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

    Robert Mitchell;Ben Mellows;Jonathan Sheard;Manuela Antonioli

Frequent Co-Authors

Timo K. Korhonen
Timo K. Korhonen University of Helsinki
Ismo Virtanen
Ismo Virtanen University of Helsinki
Dontscho Kerjaschki
Dontscho Kerjaschki Medical University of Vienna
Tobias B. Huber
Tobias B. Huber Universität Hamburg
Carol Forsblom
Carol Forsblom University of Helsinki
Oliver Kretz
Oliver Kretz Universität Hamburg
Eero Lehtonen
Eero Lehtonen University of Helsinki
Pentti Kuusela
Pentti Kuusela University of Helsinki
Matthias Kretzler
Matthias Kretzler University of Michigan–Ann Arbor
Richard E. Gilbert
Richard E. Gilbert St. Michael's Hospital

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