2026 Charles C. Caldwell: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	45	4682	4330	2111	1935	174	9575

Overview

Charles C. Caldwell is affiliated with the University of Cincinnati in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on Immunology, Epidemiology, and Critical Care and Intensive Care Medicine, as well as Pulmonary and Respiratory Medicine and Biochemistry.

The core topics of their work include Immune Response and Inflammation, Sepsis Diagnosis and Treatment, Trauma, Hemostasis, Coagulopathy, Resuscitation, Adrenal Hormones and Disorders, Blood Transfusion and Management, Immune Cells in Cancer, and Cancer Immunotherapy and Biomarkers.

Frequently publishing in venues such as Shock, Frontiers in Immunology, Surgery, Cancer Research, and Scientific Reports, Charles C. Caldwell has an extensive record of contributions to journals that focus on critical care, immunology, and surgical research.

Some of the recent papers by Charles C. Caldwell include:

Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections, 2020, JCI Insight
sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury, 2022, Proceedings of the National Academy of Sciences
A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients, 2020, The Journal of Immunology
Potential Targets to Mitigate Trauma- or Sepsis-Induced Immune Suppression, 2021, Frontiers in Immunology
Lymphocyte Immunosuppression and Dysfunction Contributing to Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS), 2020, Shock

Collaborations are a significant part of their work, with frequent co-authors including Christian B. Bergmann, Michael D. Goodman, Kenneth E. Remy, Richard S. Hotchkiss, and Monty B. Mazer. These collaborations support interdisciplinary approaches within critical care and immunology research.

Best Publications

Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.

Michail V. Sitkovsky;Dmitriy Lukashev;Sergey Apasov;Hidefumi Kojima

848
Citations
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions.

Charles C. Caldwell;Hidefumi Kojima;Dmitriy Lukashev;John Armstrong

488
Citations
IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

Jacqueline Unsinger;Margaret McGlynn;Kevin R. Kasten;Kevin R. Kasten;Andrew S. Hoekzema

376
Citations
Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis.

Xiaohong Wang;Haitao Gu;Dongze Qin;Dongze Qin;Liwang Yang;Liwang Yang

367
Citations
Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury.

Manfred Thiel;Alexander Chouker;Alexander Chouker;Akio Ohta;Akio Ohta;Edward Jackson

308
Citations
Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections.

Kenneth E. Remy;Monty Mazer;David A. Striker;Ali H. Ellebedy

305
Citations
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice

Hidefumi Kojima;Hua Gu;Saeko Nomura;Charles C. Caldwell

278
Citations
Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways

Daniel J. Hassett;Mark D. Sutton;Michael J. Schurr;Andrew B. Herr

260
Citations
Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival

Manfred Thiel;Manfred Thiel;Charles C. Caldwell;Charles C. Caldwell;Charles C. Caldwell;Simone Kreth;Satoshi Kuboki

232
Citations
Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

Anne Gulbins;Fabian Schumacher;Fabian Schumacher;Katrin Anne Becker;Barbara Wilker

217
Citations
Pseudomonas aeruginosa Exotoxin Pyocyanin Causes Cystic Fibrosis Airway Pathogenesis

Charles C. Caldwell;Yi Chen;Holly S. Goetzmann;Yonghua Hao

211
Citations
The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases.

Manfred Thiel;Charles C Caldwell;Michail V Sitkovsky

208
Citations
Neutrophils are significant producers of IL-10 during sepsis.

Kevin R. Kasten;Jared T. Muenzer;Charles C. Caldwell

178
Citations
Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion

Charles C. Caldwell;Tomohisa Okaya;Andre Martignoni;Thomas L. Husted

165
Citations
Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.

Jacqueline Unsinger;Carey-Ann D. Burnham;Jacquelyn McDonough;Michel Morre

159
Citations
The Cannabinoid Receptor 2 Is Critical for the Host Response to Sepsis

Johannes Tschöp;Kevin R. Kasten;Ruben Nogueiras;Holly S. Goetzman

159
Citations
Interleukin-7 (IL-7) Treatment Accelerates Neutrophil Recruitment through γδ T-Cell IL-17 Production in a Murine Model of Sepsis

Kevin R. Kasten;Priya S. Prakash;Jacqueline Unsinger;Holly S. Goetzman

157
Citations
Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation.

Ritha M. Belizaire;Priya S. Prakash;Jillian R. Richter;Bryce R. Robinson

157
Citations
Requirements for T Lymphocyte Migration in Explanted Lymph Nodes

Julie H. Huang;L. Isabel Cárdenas-Navia;Charles C. Caldwell;Troy J. Plumb

149
Citations
Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1α in Activated T Lymphocytes

Dmitriy Lukashev;Charles Caldwell;Akio Ohta;Pearl Chen

143
Citations

Frequent Co-Authors

Erich Gulbins University of Duisburg-Essen

Alex B. Lentsch University of Cincinnati

Michael J. Edwards University of Cincinnati

Michail V. Sitkovsky Northeastern University

Richard S. Hotchkiss Washington University in St. Louis

David A. Hildeman Cincinnati Children's Hospital Medical Center

Basilia Zingarelli Cincinnati Children's Hospital Medical Center

Yigang Wang University of Cincinnati

Matthias H. Tschöp Technical University of Munich

Edward H. Schuchman Icahn School of Medicine at Mount Sinai

External Links

Personal website of Charles C. Caldwell

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