2020 - Fellow, National Academy of Inventors
The scientist’s investigation covers issues in Acid sphingomyelinase, Biochemistry, Cell biology, Sphingomyelin and Ceramide. His Acid sphingomyelinase study combines topics from a wide range of disciplines, such as Knockout mouse, Niemann–Pick disease and Sphingomyelin phosphodiesterase. The study incorporates disciplines such as Cerebellum, Genetic disorder, Membrane biology and Enzyme replacement therapy in addition to Niemann–Pick disease.
His research in Cell biology intersects with topics in Lysosome and Endocytosis. His Sphingomyelin study incorporates themes from Apoptosis and Intracellular. His Ceramide research is multidisciplinary, incorporating perspectives in Cell, Lipid signaling and Second messenger system.
His main research concerns Acid sphingomyelinase, Biochemistry, Niemann–Pick disease, Cell biology and Molecular biology. His Acid sphingomyelinase study integrates concerns from other disciplines, such as Immunology and Sphingomyelin phosphodiesterase. His biological study spans a wide range of topics, including Lysosomal storage disease and Central nervous system.
His study in Apoptosis extends to Cell biology with its themes. His Molecular biology research integrates issues from Complementary DNA, Nucleic acid sequence, Gene and Exon. His Ceramide research includes themes of Sphingosine, Sphingolipid, Cystic fibrosis and Lipid signaling.
Edward H. Schuchman focuses on Acid sphingomyelinase, Acid Ceramidase, Cell biology, Ceramide and Sphingolipid. Edward H. Schuchman interconnects Caveolae and Neurodegeneration, Disease, Enzyme replacement therapy in the investigation of issues within Acid sphingomyelinase. Edward H. Schuchman has included themes like Transcytosis, Sphingomyelin, Endocannabinoid system and Blood–brain barrier in his Cell biology study.
His Sphingomyelin study results in a more complete grasp of Biochemistry. His work deals with themes such as Inflammation, Sphingosine-1-phosphate, Cystic fibrosis and Reperfusion injury, which intersect with Ceramide. His research in Sphingolipid intersects with topics in Thermogenesis, Adipocyte and Endocrinology.
His primary areas of investigation include Acid sphingomyelinase, Cell biology, Ceramide, Sphingosine and Acid Ceramidase. His studies in Acid sphingomyelinase integrate themes in fields like Inflammation, Quality of life and Disease, Enzyme replacement therapy. His work in the fields of Cell biology, such as Caveolae, intersects with other areas such as Radixin.
His Ceramide research focuses on Sphingolipid and how it connects with Sphingosine-1-phosphate, Sphingosine kinase, Molecular biology, Reactive oxygen species and Reperfusion injury. His work carried out in the field of Sphingosine brings together such families of science as Secretion, Phagocytosis and Microglia. His Acid Ceramidase research is classified as research in Biochemistry.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis
Pino Santana;Louis A Peña;Adriana Haimovitz-Friedman;Seamus Martin.
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
Emyr Lloyd-Evans;Anthony J Morgan;Xingxuan He;David A Smith.
Nature Medicine (2008)
Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy.
Yutaka Morita;Gloria I. Perez;Francois Paris;Silvia R. Miranda.
Nature Medicine (2000)
Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.
Silvia Muro;Carmen Garnacho;Julie A Champion;John Leferovich.
Molecular Therapy (2008)
Acid sphingomyelinase activity triggers microparticle release from glial cells.
Fabio Bianco;Cristiana Perrotta;Luisa Novellino;Maura Francolini.
The EMBO Journal (2009)
Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease.
Kenichi Horinouchi;Shai Erlich;Daniel P. Perl;Klaus Ferlinz.
Nature Genetics (1995)
Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation
Adriana Haimovitz-Friedman;Carlos Cordon-Cardo;Shariff Bayoumy;Mark Garzotto.
Journal of Experimental Medicine (1997)
Deregulation of sphingolipid metabolism in Alzheimer's disease
Xingxuan He;Yu Huang;Bin Li;Cheng-Xing Gong.
Neurobiology of Aging (2010)
Enzyme replacement and enhancement therapies: lessons from lysosomal disorders
Robert J. Desnick;Edward H. Schuchman.
Nature Reviews Genetics (2002)
Intracerebral Transplantation of Bone Marrow‐Derived Mesenchymal Stem Cells Reduces Amyloid‐Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses
Jong Kil Lee;Hee Kyung Jin;Shogo Endo;Edward H. Schuchman.
Stem Cells (2010)
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