What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Internal medicine
The scientist’s investigation covers issues in Acid sphingomyelinase, Biochemistry, Cell biology, Sphingomyelin and Ceramide.
His Acid sphingomyelinase study combines topics from a wide range of disciplines, such as Knockout mouse, Niemann–Pick disease and Sphingomyelin phosphodiesterase.
The study incorporates disciplines such as Cerebellum, Genetic disorder, Membrane biology and Enzyme replacement therapy in addition to Niemann–Pick disease.
His research in Cell biology intersects with topics in Lysosome and Endocytosis.
His Sphingomyelin study incorporates themes from Apoptosis and Intracellular.
His Ceramide research is multidisciplinary, incorporating perspectives in Cell, Lipid signaling and Second messenger system.
His most cited work include:
- Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis (703 citations)
- Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium (619 citations)
- Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. (522 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Acid sphingomyelinase, Biochemistry, Niemann–Pick disease, Cell biology and Molecular biology.
His Acid sphingomyelinase study integrates concerns from other disciplines, such as Immunology and Sphingomyelin phosphodiesterase.
His biological study spans a wide range of topics, including Lysosomal storage disease and Central nervous system.
His study in Apoptosis extends to Cell biology with its themes.
His Molecular biology research integrates issues from Complementary DNA, Nucleic acid sequence, Gene and Exon.
His Ceramide research includes themes of Sphingosine, Sphingolipid, Cystic fibrosis and Lipid signaling.
He most often published in these fields:
- Acid sphingomyelinase (37.90%)
- Biochemistry (21.28%)
- Niemann–Pick disease (20.70%)
What were the highlights of his more recent work (between 2017-2021)?
- Acid sphingomyelinase (37.90%)
- Acid Ceramidase (15.74%)
- Cell biology (17.49%)
In recent papers he was focusing on the following fields of study:
Edward H. Schuchman focuses on Acid sphingomyelinase, Acid Ceramidase, Cell biology, Ceramide and Sphingolipid.
Edward H. Schuchman interconnects Caveolae and Neurodegeneration, Disease, Enzyme replacement therapy in the investigation of issues within Acid sphingomyelinase.
Edward H. Schuchman has included themes like Transcytosis, Sphingomyelin, Endocannabinoid system and Blood–brain barrier in his Cell biology study.
His Sphingomyelin study results in a more complete grasp of Biochemistry.
His work deals with themes such as Inflammation, Sphingosine-1-phosphate, Cystic fibrosis and Reperfusion injury, which intersect with Ceramide.
His research in Sphingolipid intersects with topics in Thermogenesis, Adipocyte and Endocrinology.
Between 2017 and 2021, his most popular works were:
- Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease (42 citations)
- Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM (20 citations)
- Sphingolipids as targets for inhalation treatment of cystic fibrosis (15 citations)
In his most recent research, the most cited papers focused on:
- Gene
- Enzyme
- Internal medicine
His primary areas of investigation include Acid sphingomyelinase, Cell biology, Ceramide, Sphingosine and Acid Ceramidase.
His studies in Acid sphingomyelinase integrate themes in fields like Inflammation, Quality of life and Disease, Enzyme replacement therapy.
His work in the fields of Cell biology, such as Caveolae, intersects with other areas such as Radixin.
His Ceramide research focuses on Sphingolipid and how it connects with Sphingosine-1-phosphate, Sphingosine kinase, Molecular biology, Reactive oxygen species and Reperfusion injury.
His work carried out in the field of Sphingosine brings together such families of science as Secretion, Phagocytosis and Microglia.
His Acid Ceramidase research is classified as research in Biochemistry.
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