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Biology and Biochemistry

D-Index
98
Citations
44653
World Ranking
1631
National Ranking
911

Overview

Richard Kolesnick is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions also in medicine. A notable focus of their work lies within molecular biology, radiation, pulmonary and respiratory medicine, neurology, and immunology.

The core topics explored in Kolesnick's body of work include sphingolipid metabolism and signaling, extracellular vesicles in disease, advanced radiotherapy techniques, neuroinflammation and neurodegeneration mechanisms, phagocytosis and immune regulation, radiation therapy and dosimetry, and management of metastatic bone disease.

They have published extensively in several scientific journals. Frequent venues for their publications are:

  • International Journal of Radiation Oncology*Biology*Physics
  • Basic Research in Cardiology
  • Journal of Thrombosis and Haemostasis
  • Cellular Physiology and Biochemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

Among their recent papers are the following:

  • Phase 3 Multi-Center, Prospective, Randomized Trial Comparing Single-Dose 24 Gy Radiation Therapy to a 3-Fraction SBRT Regimen in the Treatment of Oligometastatic Cancer (2021, International Journal of Radiation Oncology*Biology*Physics)
  • Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles (2022, Basic Research in Cardiology)
  • Homozygous Smpd1 deficiency aggravates brain ischemia/reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia (2020, Basic Research in Cardiology)
  • Factor VIIa releases phosphatidylserine-enriched extracellular vesicles from endothelial cells by activating acid sphingomyelinase (2023, Journal of Thrombosis and Haemostasis)
  • MicroRNA-10a enrichment in factor VIIa-released endothelial extracellular vesicles: potential mechanisms (2023, Journal of Thrombosis and Haemostasis)

Kolesnick has collaborated frequently with a number of coauthors over their career. Most common collaborators include:

  • Zvi Fuks
  • Ayan Mohamud Yusuf
  • Nina Hagemann
  • Carlotta Martiny
  • Christoph Kleinschnitz

Best Publications

  • Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

    Marcel Verheij;Marcel Verheij;Ron Bose;Xin Hua Lin;Bei Yao

  • Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

    Monica Garcia-Barros;Francois Paris;Carlos Cordon-Cardo;David Lyden

  • Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

    François Paris;Zvi Fuks;Anthony Kang;Paola Capodieci

  • The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

    Richard Kolesnick;David W. Golde

  • Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

    A. Haimovitz-Friedman;Chu-Cheng Kan;D. Ehleiter;R. S. Persaud

  • REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

    Richard N. Kolesnick;Martin Krönke

  • Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

    Caroline A. Lindemans;Caroline A. Lindemans;Marco Calafiore;Anna M. Mertelsmann;Margaret H. O'Connor

  • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

    Ron Bose;Marcel Verheij;Adriana Haimovitz-Friedman;Kathleen Scotto

  • Signal transduction of stress via ceramide

    Shalini Mathias;Louis A. Peña;Richard N. Kolesnick

  • Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

    Pino Santana;Louis A Peña;Adriana Haimovitz-Friedman;Seamus Martin

  • CD95 signaling via ceramide-rich membrane rafts.

    Heike Grassme;Andreas Jekle;Andrea Riehle;Heinz Schwarz

  • Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy.

    Yutaka Morita;Gloria I. Perez;Francois Paris;Silvia R. Miranda

  • Radiation and ceramide-induced apoptosis

    Richard Kolesnick;Zvi Fuks

  • Signal transduction through lipid second messengers

    Sarah Spiegel;David Foster;Richard Kolesnick

  • Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.

    Alan M. Hanash;Jarrod A. Dudakov;Guoqiang Hua;Margaret H. O’Connor

  • Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

    W D Jarvis;R N Kolesnick;F A Fornari;R S Traylor

  • Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts.

    H. Grassmé;V. Jendrossek;A. Riehle;G. von Kürthy

  • Kinase suppressor of Ras is ceramide-activated protein kinase.

    Yuhua Zhang;Bei Yao;Sylvie Delikat;Shariff Bayoumy

  • Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system.

    Kenneth A. Dressler;Shalini Mathias;Richard N. Kolesnick

  • The therapeutic potential of modulating the ceramide/sphingomyelin pathway

    Richard Kolesnick

Frequent Co-Authors

Zvi Fuks
Zvi Fuks Memorial Sloan Kettering Cancer Center
Erich Gulbins
Erich Gulbins University of Duisburg-Essen
Marcel R.M. van den Brink
Marcel R.M. van den Brink Memorial Sloan Kettering Cancer Center
Chen Liu
Chen Liu Yale University
Jonathan L. Tilly
Jonathan L. Tilly Northeastern University
Simon N. Powell
Simon N. Powell Memorial Sloan Kettering Cancer Center
Carlos Cordon-Cardo
Carlos Cordon-Cardo Icahn School of Medicine at Mount Sinai
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Robert R. Jenq
Robert R. Jenq The University of Texas MD Anderson Cancer Center
Edward H. Schuchman
Edward H. Schuchman Icahn School of Medicine at Mount Sinai

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