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Biology and Biochemistry

D-Index
86
Citations
27077
World Ranking
2957
National Ranking
1513

Overview

Jonathan L. Tilly is affiliated with Northeastern University in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a substantive focus on molecular biology. The scientist has contributed notably to fields including mitochondrial function and pathology, reproductive biology and fertility, pluripotent stem cells research, metabolism and genetic disorders, renal and related cancers, metabolomics and mass spectrometry studies, and CRISPR and genetic engineering.

They have published extensively, with a total of 42 works in biochemistry, genetics, and molecular biology, and an additional 13 in medicine. Their scholarship also covers various subfields such as molecular biology (33 publications), public health, environmental and occupational health (7 publications), clinical biochemistry (5 publications), pediatrics, perinatology and child health (3 publications), and immunology (2 publications).

Their frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Stem Cells
  • Aging
  • Stem Cells and Development
  • BMC Bioinformatics

Jonathan L. Tilly has co-authored numerous papers with several colleagues, including:

  • Dori C. Woods
  • Konstantin Khrapko
  • Zoë Fleischmann
  • Melissa Franco
  • Konstantin Popadin

Among their recent publications are:

  • "Workflow Optimization for Identification of Female Germline or Oogonial Stem Cells in Human Ovarian Cortex Using Single-Cell RNA Sequence Analysis," 2022, published in Stem Cells
  • "Estrogen regulation of germline stem cell differentiation as a mechanism contributing to female reproductive aging," 2020, published in Aging
  • "3GOLD: optimized Levenshtein distance for clustering third-generation sequencing data," 2022, published in BMC Bioinformatics
  • "Dynamics of the most common pathogenic mtDNA variant m.3243A > G demonstrate frequency-dependency in blood and positive selection in the germline," 2022, published in Human Molecular Genetics
  • "Revisiting Claims of the Continued Absence of Functional Germline Stem Cells in Adult Ovaries," 2022, published in Stem Cells

Best Publications

  • Germline stem cells and follicular renewal in the postnatal mammalian ovary

    Joshua Johnson;Jacqueline Canning;Tomoko Kaneko;James K. Pru

  • A sperm ion channel required for sperm motility and male fertility

    Dejian Ren;Betsy Navarro;Gloria Perez;Alexander C. Jackson

  • Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood

    Joshua Johnson;Jessamyn Bagley;Malgorzata Skaznik-Wikiel;Ho-Joon Lee

  • Defects in regulation of apoptosis in caspase-2-deficient mice

    Louise Bergeron;Gloria I. Perez;Glen Macdonald;Lianfa Shi

  • Involvement of apoptosis in ovarian follicular atresia and postovulatory regression.

    Jonathan L. Tilly;Kim I. Kowalski;Alan L. Johnson;Aaron J.W. Hsueh

  • Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women

    Yvonne A R White;Dori C Woods;Yasushi Takai;Osamu Ishihara

  • Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy.

    Yutaka Morita;Gloria I. Perez;Francois Paris;Silvia R. Miranda

  • Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals.

    Tiina Matikainen;Gloria I. Perez;Andrea Jurisicova;Andrea Jurisicova;James K. Pru

  • Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels.

    Jonathan L. Tilly;Kim I. Tilly;Maura L. Kenton;Alan L. Johnson

  • Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism.

    J. L. Tilly;H. Billig;K. I. Kowalski;A. J. W. Hsueh

  • Oocyte apoptosis: like sand through an hourglass.

    Yutaka Morita;Jonathan L. Tilly

  • Commuting the death sentence: how oocytes strive to survive.

    Jonathan L. Tilly

  • Apoptosis and ovarian function

    Jonathan L. Tilly

  • Prolongation of ovarian lifespan into advanced chronological age by Bax -deficiency

    Gloria I. Perez;Rodolfo Robles;C. Michael Knudson;Jodi A. Flaws;Jodi A. Flaws

  • APOPTOSIS-ASSOCIATED SIGNALING PATHWAYS ARE REQUIRED FOR CHEMOTHERAPY-MEDIATED FEMALE GERM CELL DESTRUCTION

    Perez Gi;Knudson Cm;Leykin L;Korsmeyer Sj

  • Gonadotropin Suppression of Apoptosis in Cultured Preovulatory Follicles: Mediatory Role of Endogenous Insulin-Like Growth Factor I*

    Sang-Young Chun;H. Billig;J. L. Tilly;I. Furuta

  • INHIBITORS OF OXIDATIVE STRESS MIMIC THE ABILITY OF FOLLICLE-STIMULATING HORMONE TO SUPPRESS APOPTOSIS IN CULTURED RAT OVARIAN FOLLICLES

    Jonathan L. Tilly;Kim I. Tilly

  • Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors.

    J. S. Tapanainen;J. L. Tilly;K. K. Vihko;A. J. W. Hsueh

  • Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation

    Jonathan L. Tilly;Aaron J. W. Hsueh

  • Germline stem cells and follicular renewal in the postnatal mammalian ovary

    Joshua Johnson;Jacqueline Canning;Tomoko Kanedo;James K. Pru

Frequent Co-Authors

Andrea Jurisicova
Andrea Jurisicova University of Toronto
Bo R. Rueda
Bo R. Rueda Massachusetts General Hospital
Aaron J. W. Hsueh
Aaron J. W. Hsueh Stanford University
David A. Sinclair
David A. Sinclair Harvard University
Richard Kolesnick
Richard Kolesnick Memorial Sloan Kettering Cancer Center
Stanley J. Korsmeyer
Stanley J. Korsmeyer Harvard University
Patricia B. Hoyer
Patricia B. Hoyer University of Arizona
John C. Reed
John C. Reed Johnson & Johnson (United States)
David H. Sherr
David H. Sherr Boston University
Richard A. Flavell
Richard A. Flavell Yale University

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