2026 David E. Clapham: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	141	254	224	171	148	429	90338

Overview

David E. Clapham is affiliated with the Howard Hughes Medical Institute in the United States. Their research spans several main fields, including Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Their work delves into subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Sensory Systems, Complementary and Alternative Medicine, and Physiology.

The scientist has contributed to numerous research topics, which include:

Ion Channels and Receptors
Ion channel regulation and function
Photoreceptor and optogenetics research
Neuroscience and Neural Engineering
Herbal Medicine Research Studies
Neuroscience and Neuropharmacology Research
Cardiac electrophysiology and arrhythmias

Selected recent papers authored or co-authored by Clapham are:

A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility, 2022, Cell
Odontoblast TRPC5 channels signal cold pain in teeth, 2021, Science Advances
The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins, 2023, eLife
Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na ⁺ channels in nanodisc, 2020, Proceedings of the National Academy of Sciences
Visualizing synaptic dopamine efflux with a 2D composite nanofilm, 2022, eLife

Frequent co-authors include:

Sebastián Brauchi
Patrick R. Houlihan
Nathaniel T. Blair
Ingrid Carvacho
Dipayan Chaudhuri

Publication venues where Clapham has frequently published are:

IUPHAR/BPS Guide to Pharmacology CITE
bioRxiv (Cold Spring Harbor Laboratory)
Policy Press eBooks
Cell
eLife

In addition to journal publications, Clapham has contributed to book publications with Policy Press. Two books titled Inhabitation in Nature were published in 2023 under this publisher.

Best Publications

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

W. A. Catterall;K. G. Chandy;D. E. Clapham;G. A. Gutman

13467
Citations
TRP channels as cellular sensors

David E. Clapham

3288
Citations
An Introduction to TRP Channels

I. Scott Ramsey;Markus Delling;David E. Clapham

1865
Citations
The mitochondrial calcium uniporter is a highly selective ion channel

Yuriy Kirichok;Grigory Krapivinsky;David E. Clapham

1612
Citations
The βγ subunits of GTP-binding proteins activate the muscarinic K + channel in heart

Diomedes E. Logothetis;Yoshihisa Kurachi;Jonas Galper;Eva J. Neer

1553
Citations
The trp ion channel family

David E. Clapham;David E. Clapham;Loren W. Runnels;Loren W. Runnels;Carsten Strübing;Carsten Strübing

1483
Citations
G PROTEIN BETA GAMMA SUBUNITS

David E. Clapham;Eva J. Neer

1234
Citations
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.

G. Krapivinsky;E. A. Gordon;K. Wickman;B. Velimirović

1082
Citations
A sperm ion channel required for sperm motility and male fertility

Dejian Ren;Betsy Navarro;Gloria Perez;Alexander C. Jackson

1066
Citations
Roles of G protein subunits in transmembrane signalling.

Eva J. Neer;David E. Clapham;David E. Clapham

1047
Citations
TRPV3 is a calcium-permeable temperature-sensitive cation channel

Haoxing Xu;I. Scott Ramsey;Suhas A. Kotecha;Magdalene M. Moran

1023
Citations
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.

Jochen Reiser;Krishna R Polu;Clemens C Möller;Peter Kenlan

988
Citations
Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes

James D Lechleiter;Steven Girard;Ernest Peralta;David Clapham

901
Citations
New roles for G-protein beta gamma-dimers in transmembrane signalling.

David E. Clapham;Eva J. Neer

885
Citations
TRPC1 and TRPC5 form a novel cation channel in mammalian brain.

Carsten Strübing;Grigory Krapivinsky;Luba Krapivinsky;David E Clapham

854
Citations
TRP-PLIK, a bifunctional protein with kinase and ion channel activities.

Loren W. Runnels;Lixia Yue;David E. Clapham

846
Citations
A Unified Nomenclature for the Superfamily of TRP Cation Channels

Craig Montell;Lutz Birnbaumer;Veit Flockerzi;René J. Bindels

822
Citations
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

Haoxing Xu;Markus Delling;Markus Delling;Janice C Jun;Janice C Jun;David E Clapham;David E Clapham

704
Citations
Genome-Wide RNAi Screen Identifies Letm1 as a Mitochondrial Ca2+/H+ Antiporter

Dawei Jiang;Linlin Zhao;David E. Clapham

690
Citations
EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

Yasemin Sancak;Andrew L. Markhard;Toshimori Kitami;Toshimori Kitami;Erika Kovács-Bogdán

676
Citations

Frequent Co-Authors

Sara von Arnold Swedish University of Agricultural Sciences

Haoxing Xu University of Michigan–Ann Arbor

Eva J. Neer Brigham and Women's Hospital

Xiaowei Zhuang Harvard University

Jian Li ShanghaiTech University

William T. Pu Boston Children's Hospital

Michael J. Ackerman Mayo Clinic

Bonnie A. Wallace Birkbeck, University of London

Nancy C. Andrews Duke University

Simon Gaisford University College London

External Links

Personal website of David E. Clapham

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