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Biology and Biochemistry

D-Index
73
Citations
16228
World Ranking
6038
National Ranking
464

Overview

David J. Beech is affiliated with the University of Leeds in the United Kingdom. Their research primarily focuses on fields related to Medicine and Biochemistry, Genetics and Molecular Biology, with extensive contributions in subfields such as Physiology, Molecular Biology, Pulmonary and Respiratory Medicine, Cell Biology, and Sensory Systems.

Their body of work spans several topics, notably:

  • Erythrocyte Function and Pathophysiology
  • Blood properties and coagulation
  • Ion Channels and Receptors
  • Ion channel regulation and function
  • Phytochemicals and Antioxidant Activities
  • Adipose Tissue and Metabolism
  • Hemoglobin structure and function

Some of the recent papers authored or coauthored by David J. Beech include:

  • "Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation" (2020), Journal of Bone and Mineral Research
  • "Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells" (2020), eLife
  • "PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing" (2023), Communications Biology
  • "Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels" (2020), Cell Reports
  • "Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension" (2022), Circulation Research

David J. Beech has collaborated frequently with several researchers, including:

  • Richard M. Cubbon
  • Richard Foster
  • Gregory Parsonage
  • Laeticia Lichtenstein
  • Mark T. Kearney

Their publications have appeared predominantly in specific venues, reflecting their research focus:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Circulation
  • Communications Biology
  • Circulation Research

Best Publications

  • Piezo1 integration of vascular architecture with physiological force

    Jing Li;Bing Hou;Sarka Tumova;Katsuhiko Muraki

  • TrpC1 Is a Membrane-Spanning Subunit of Store-Operated Ca2+ Channels in Native Vascular Smooth Muscle Cells

    Shang-Zhong Xu;David J. Beech

  • TRPC channel activation by extracellular thioredoxin

    Shang Zhong Xu;Piruthivi Sukumar;Fanning Zeng;Jing Li

  • Critical Intracellular Ca2+ Dependence of Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel Activation

    Damian McHugh;Richard Flemming;Shang-Zhong Xu;Anne-Laure Perraud

  • Block of TRPC5 channels by 2-aminoethoxydiphenyl borate : a differential, extracellular and voltage-dependent effect

    Shang-Zhong Xu;Fanning Zeng;Guylain Boulay;Christian Grimm

  • Non-selective cationic channels of smooth muscle and the mammalian homologues of Drosophila TRP

    D. J. Beech;K. Muraki;R. Flemming

  • A diffusible second messenger mediates one of the pathways coupling receptors to calcium channels in rat sympathetic neurons.

    Laurent Bernheim;David J. Beech;Bertil Hille

  • K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells.

    D.J. Beech;H. Zhang;K. Nakao;T.B. Bolton

  • Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

    Baptiste Rode;Jian Shi;Naima Endesh;Mark J. Drinkhill

  • Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(−/−) mice

    Xibao Liu;Kwong Tai Cheng;Bidhan C. Bandyopadhyay;Biswaranjan Pani

  • Cholesterol Depletion Impairs Vascular Reactivity to Endothelin-1 by Reducing Store-Operated Ca2+ Entry Dependent on TRPC1

    Andreas Bergdahl;Maria F. Gomez;Karl Dreja;Shang-Zhong Xu

  • Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons

    David J. Beech;Laurent Bernheim;Bertil Hille

  • Upregulated TRPC1 Channel in Vascular Injury In Vivo and Its Role in Human Neointimal Hyperplasia

    B. Kumar;K. Dreja;S.S. Shah;A. Cheong

  • Englerin A is a Potent and Selective Activator of TRPC4 and TRPC5 Calcium Channels

    Yasemin Akbulut;Hannah J. Gaunt;Katsuhiko Muraki;Melanie J. Ludlow

  • Intracellular Ca2+ buffers disrupt muscarinic suppression of Ca2+ current and M current in rat sympathetic neurons

    David J. Beech;Laurent Bernheim;Alistair Mathie;Bertil Hille

  • Orai1 and CRAC Channel Dependence of VEGF-Activated Ca2+ Entry and Endothelial Tube Formation

    Jing Li;Richard M. Cubbon;Lesley A. Wilson;Mohamed S. Amer;Mohamed S. Amer

  • Two components of potassium current activated by depolarization of single smooth muscle cells from the rabbit portal vein.

    D J Beech;T B Bolton

  • Activation of the Cl− Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor

    Xin Jin;Xin Jin;Shihab Shah;Yani Liu;Huiran Zhang

  • TRPC1: store-operated channel and more

    David J Beech

  • Piezo1 Integration of Vascular Architecture with Physiological Force

    Jing Li;Bing Hou;Katsuhiko Muraki;Justin Ainscough

Frequent Co-Authors

Lin-Hua Jiang
Lin-Hua Jiang University of Leeds
Wei Yang
Wei Yang South China University of Technology
Ajay M. Shah
Ajay M. Shah King's College London
Keith M. Channon
Keith M. Channon University of Oxford
Nikita Gamper
Nikita Gamper University of Leeds
Peter J. Grant
Peter J. Grant University of Leeds
Bertil Hille
Bertil Hille University of Washington
Herbert Waldmann
Herbert Waldmann Max Planck Society
Sreenivasan Ponnambalam
Sreenivasan Ponnambalam University of Leeds
Jianhong Luo
Jianhong Luo Zhejiang University

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