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Biology and Biochemistry

D-Index
68
Citations
14255
World Ranking
7911
National Ranking
3588

Overview

Indu S. Ambudkar is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Neuroscience and Medicine, with a focused interest in Sensory Systems and Cellular and Molecular Neuroscience.

Their work covers multiple subfields including Plant Science, Molecular Biology, and Biochemistry. The main topics addressed in their research include Ion Channels and Receptors, Neurobiology and Insect Physiology Research, and Phytochemicals and Antioxidant Activities. Other topics of interest include Ion channel regulation and function, Postharvest Quality and Shelf Life Management, Respiratory and Cough-Related Research, and Food Allergy and Anaphylaxis Research.

Ambudkar's recent publications feature studies on calcium entry mechanisms, viral infection processes, and protective agents against irradiation-induced damage. Notable papers include:

  • STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca 2+ entry with NFAT1 activation, 2020, Proceedings of the National Academy of Sciences
  • Functional communication between IP 3 R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE, 2022, Proceedings of the National Academy of Sciences
  • TRPC1 participates in the HSV-1 infection process by facilitating viral entry, 2020, Science Advances
  • Mitochondria-targeted antioxidant protects against irradiation-induced salivary gland hypofunction, 2021, Scientific Reports
  • PIP2 and septin control STIM1/Orai1 assembly by regulating cytoskeletal remodeling via a CDC42-WASP/WAVE-ARP2/3 protein complex, 2021, Cell Calcium

Their frequent co-authors include Hwei Ling Ong, Changyu Zheng, Xibao Liu, Krishna Prasad Subedi, and Hassan Saadi. The scientist regularly publishes in venues such as the Proceedings of the National Academy of Sciences, Cell Calcium, Scientific Reports, Biomolecules, and Nature Communications, reflecting a consistent engagement with journals relevant to cellular and molecular neuroscience topics.

Best Publications

  • Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx EVIDENCE FOR SIMILARITIES IN STORE-OPERATED AND CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL COMPONENTS

    Hwei Ling Ong;Kwong Tai Cheng;Xibao Liu;Bidhan C. Bandyopadhyay

  • Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.

    Timothy P. Lockwich;Xibao Liu;Brij B. Singh;Julie Jadlowiec

  • Trp1, a Candidate Protein for the Store-operated Ca2+Influx Mechanism in Salivary Gland Cells

    Xibao Liu;Weiching Wang;Brij B. Singh;Timothy Lockwich

  • A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery

    Xibao Liu;Bidhan B. Bandyopadhyay;Tetsuji Nakamoto;Brij B. Singh

  • Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions

    Kwong Tai Cheng;Xibao Liu;Hwei Ling Ong;William Swaim

  • TRPC1: the link between functionally distinct store-operated calcium channels.

    Indu S Ambudkar;Hwei Ling Ong;Xibao Liu;Bidhan C Bandyopadhyay

  • Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca2+ Channel Sulfhydration

    Yi Liu;Yi Liu;Ruili Yang;Xibao Liu;Yu Zhou

  • Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(−/−) mice

    Xibao Liu;Kwong Tai Cheng;Bidhan C. Bandyopadhyay;Biswaranjan Pani

  • Functional Requirement for Orai1 in Store-operated TRPC1-STIM1 Channels

    Kwong Tai Cheng;Xibao Liu;Hwei Ling Ong;Indu S. Ambudkar

  • Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1.

    So-ching W. Brazer;Brij B. Singh;Xibao Liu;William Swaim

  • TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces.

    Indu S. Ambudkar;Lorena Brito de Souza;Hwei Ling Ong

  • Contribution and regulation of TRPC channels in store-operated Ca2+ entry.

    Kwong Tai Cheng;Hwei Ling Ong;Xibao Liu;Indu S. Ambudkar

  • VAMP2-Dependent Exocytosis Regulates Plasma Membrane Insertion of TRPC3 Channels and Contributes to Agonist-Stimulated Ca2+ Influx

    Brij B Singh;Timothy P. Lockwich;Bidhan C. Bandyopadhyay;Xibao Liu

  • TRPC1 is required for functional store-operated Ca2+ channels. Role of acidic amino acid residues in the S5-S6 region.

    Xibao Liu;Brij B. Singh;Indu S. Ambudkar

  • Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane

    Lizheng Qin;Xibao Liu;Qifei Sun;Zhipeng Fan

  • Stabilization of Cortical Actin Induces Internalization of Transient Receptor Potential 3 (Trp3)-associated Caveolar Ca2+ Signaling Complex and Loss of Ca2+ Influx without Disruption of Trp3-Inositol Trisphosphate Receptor Association

    Timothy P. Lockwich;Brij B. Singh;Xibao Liu;Indu S. Ambudkar

  • Calmodulin Regulates Ca2+-Dependent Feedback Inhibition of Store-Operated Ca2+ Influx by Interaction with a Site in the C Terminus of TrpC1

    Brij B Singh;Xibao Liu;Jisen Tang;Michael X Zhu

  • Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE).

    Biswaranjan Pani;Hwei Ling Ong;Xibao Liu;Kristina Rauser

  • Canonical transient receptor potential 1 plays a role in basic fibroblast growth factor (bFGF)/FGF receptor-1-induced Ca2+ entry and embryonic rat neural stem cell proliferation.

    Alessandra Fiorio Pla;Dragan Maric;So-Ching Brazer;Paolo Giacobini

  • Molecular Analysis of a Store-operated and 2-Acetyl-sn-glycerol-sensitive Non-selective Cation Channel HETEROMERIC ASSEMBLY OF TRPC1-TRPC3

    Xibao Liu;Bidhan C. Bandyopadhyay;Brij B. Singh;Klaus Groschner

Frequent Co-Authors

Bruce J. Baum
Bruce J. Baum National Institutes of Health
Stefan Feske
Stefan Feske New York University
Lutz Birnbaumer
Lutz Birnbaumer National Institutes of Health
Michael X. Zhu
Michael X. Zhu The University of Texas Health Science Center at Houston
George S. Roth
George S. Roth National Institutes of Health
Donald L. Gill
Donald L. Gill Pennsylvania State University
James E. Melvin
James E. Melvin National Institutes of Health
Shmuel Muallem
Shmuel Muallem National Institutes of Health
Songlin Wang
Songlin Wang Capital Medical University
Suresh V. Ambudkar
Suresh V. Ambudkar National Institutes of Health

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