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Alexander A. Khromykh

Alexander A. Khromykh

D-Index & Metrics

Microbiology

D-Index
75
Citations
17280
World Ranking
1521
National Ranking
47

Overview

Alexander A. Khromykh is affiliated with the University of Queensland in Australia. Their research is primarily situated within the field of Medicine, with a focus on several subfields including Infectious Diseases, Public Health, Environmental and Occupational Health, Immunology, Molecular Biology, and Neurology. The scientist's work spans multiple topics related to viral infections, disease control, and immune response mechanisms.

Their main topics of study cover:

  • SARS-CoV-2 and COVID-19 Research
  • Mosquito-borne diseases and control
  • Viral Infections and Vectors
  • COVID-19 Clinical Research Studies
  • Insect symbiosis and bacterial influences
  • Animal Virus Infections Studies
  • Immunotherapy and Immune Responses

Frequent co-authors who have collaborated extensively with Khromykh include:

  • Daniel Watterson
  • Alberto A. Amarilla
  • Naphak Modhiran
  • Rhys Parry
  • Julian D. J. Sng

Their research has been published repeatedly in several venues, reflecting diverse interests in virology and related disciplines. The main publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Viruses
  • Nature Communications
  • Science Advances
  • Vaccines

Notable recent papers by Khromykh include:

  • A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses, 2021, Nature Communications
  • SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein, 2022, Molecular Psychiatry
  • A broadly protective antibody that targets the flavivirus NS1 protein, 2021, Science
  • Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction, 2022, ACS Central Science
  • Zika virus noncoding RNA suppresses apoptosis and is required for virus transmission by mosquitoes, 2020, Nature Communications

Best Publications

  • Ultrastructure of Kunjin virus-infected cells: colocalization of NS1 and NS3 with double-stranded RNA, and of NS2B with NS3, in virus-induced membrane structures.

    Edwin G. Westaway;Jason M. MacKenzie;Mark T. Kenney;Malcolm K. Jones

  • A Highly Structured, Nuclease-Resistant, Noncoding RNA Produced by Flaviviruses Is Required for Pathogenicity

    Gorben P. Pijlman;Anneke Funk;Natasha Kondratieva;Jason Leung

  • Essential Role of Cyclization Sequences in Flavivirus RNA Replication

    Alexander A. Khromykh;Hedije Meka;Kimberley J. Guyatt;Edwin G. Westaway

  • Subcellular localization and some biochemical properties of the flavivirus Kunjin nonstructural proteins NS2A and NS4A

    Jason M. Mackenzie;Alexander A. Khromykh;Malcolm K. Jones;Edwin G. Westaway

  • Subgenomic Replicons of the Flavivirus Kunjin: Construction and Applications

    A A Khromykh;E G Westaway

  • Inhibition of Interferon Signaling by the New York 99 Strain and Kunjin Subtype of West Nile Virus Involves Blockage of STAT1 and STAT2 Activation by Nonstructural Proteins

    Wen Jun Liu;Xiang Ju Wang;Xiang Ju Wang;Vladislav V. Mokhonov;Vladislav V. Mokhonov;Pei Yong Shi

  • A Single Amino Acid Substitution in the West Nile Virus Nonstructural Protein NS2A Disables Its Ability To Inhibit Alpha/Beta Interferon Induction and Attenuates Virus Virulence in Mice

    Wen Jun Liu;Xiang Ju Wang;David C. Clark;Mario Lobigs

  • Cholesterol manipulation by West Nile virus perturbs the cellular immune response.

    Jason M. Mackenzie;Alexander A. Khromykh;Robert G. Parton

  • Noncoding Flavivirus RNA Displays RNA Interference Suppressor Activity in Insect and Mammalian Cells

    Esther Schnettler;Mark G. Sterken;Jason Y. Leung;Stefan W. Metz

  • Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5

    Helene Malet;Marie-Pierre Egloff;Barbara Selisko;Rebecca Elizabeth Butcher

  • Role of Nonstructural Protein NS2A in Flavivirus Assembly

    Jason Y. Leung;Gorben P. Pijlman;Gorben P. Pijlman;Natasha Kondratieva;Jennifer Hyde

  • Regulated Cleavages at the West Nile Virus NS4A-2K-NS4B Junctions Play a Major Role in Rearranging Cytoplasmic Membranes and Golgi Trafficking of the NS4A Protein

    Jojanneke Roosendaal;Edwin G. Westaway;Alexander Khromykh;Alexander Khromykh;Jason M. Mackenzie;Jason M. Mackenzie

  • Chikungunya Virus Nonstructural Protein 2 Inhibits Type I/II Interferon-Stimulated JAK-STAT Signaling

    Jelke J. Fros;Wen Jun Liu;Natalie A. Prow;Corinne Geertsema

  • The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT Signaling

    Maudry Laurent-Rolle;Elena F. Boer;Kirk J. Lubick;James B. Wolfinbarger

  • RNA structures required for production of subgenomic flavivirus RNA

    Anneke Funk;Katherine Truong;Tomoko Nagasaki;Shessy Torres

  • West Nile virus encodes a microRNA-like small RNA in the 3′ untranslated region which up-regulates GATA4 mRNA and facilitates virus replication in mosquito cells

    Mazhar Hussain;Shessy Torres;Esther Schnettler;Anneke Funk

  • Coupling between Replication and Packaging of Flavivirus RNA: Evidence Derived from the Use of DNA-Based Full-Length cDNA Clones of Kunjin Virus

    Alexander A. Khromykh;Andrei N. Varnavski;Andrei N. Varnavski;Petra L. Sedlak;Petra L. Sedlak;Edwin G. Westaway;Edwin G. Westaway

  • Analysis of Adaptive Mutations in Kunjin Virus Replicon RNA Reveals a Novel Role for the Flavivirus Nonstructural Protein NS2A in Inhibition of Beta Interferon Promoter-Driven Transcription

    Wen Jun Liu;Hua Bo Chen;Hua Bo Chen;Xiang Ju Wang;Xiang Ju Wang;Hester Huang;Hester Huang

  • NS1′ of Flaviviruses in the Japanese Encephalitis Virus Serogroup Is a Product of Ribosomal Frameshifting and Plays a Role in Viral Neuroinvasiveness

    Ezequiel Balmori Melian;Edward Hinzman;Tomoko Nagasaki;Andrew E. Firth

  • A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability.

    Stephanie L. Moon;John R. Anderson;Yutaro Kumagai;Carol J. Wilusz

  • Molecular and Functional Analyses of Kunjin Virus Infectious cDNA Clones Demonstrate the Essential Roles for NS2A in Virus Assembly and for a Nonconservative Residue in NS3 in RNA Replication

    Wen Jun Liu;Hua Bo Chen;Alexander A. Khromykh

Frequent Co-Authors

Roy A. Hall
Roy A. Hall University of Queensland
Andreas Suhrbier
Andreas Suhrbier QIMR Berghofer Medical Research Institute
Jason M. Mackenzie
Jason M. Mackenzie University of Melbourne
Gorben P. Pijlman
Gorben P. Pijlman Wageningen University & Research
Paul R. Young
Paul R. Young University of Queensland
Helle Bielefeldt-Ohmann
Helle Bielefeldt-Ohmann University of Queensland
John S. Mackenzie
John S. Mackenzie Curtin University
Mario Lobigs
Mario Lobigs University of Queensland
Pei-Yong Shi
Pei-Yong Shi GlaxoSmithKline (United Kingdom)
Luiz Tadeu Moraes Figueiredo
Luiz Tadeu Moraes Figueiredo Universidade de São Paulo

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