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Immunology

D-Index
73
Citations
29758
World Ranking
2086
National Ranking
143

Overview

Luca Gattinoni is affiliated with the University of Regensburg in Germany. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with significant contributions to subfields such as Immunology, Oncology, Biomedical Engineering, Molecular Biology, and Cancer Research.

The scientific topics addressed in Gattinoni's work include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • Viral Infectious Diseases and Gene Expression in Insects
  • Virus-based gene therapy research
  • Nanoplatforms for cancer theranostics

Gattinoni has published extensively in the following venues, reflecting a strong focus on immunology and related therapies:

  • Nature Immunology
  • Zenodo (CERN European Organization for Nuclear Research)
  • Signal Transduction and Targeted Therapy
  • Nature Nanotechnology
  • Cytotherapy

Key recent papers authored or co-authored by Gattinoni include:

  • "Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans" (2020, Nature Immunology)
  • "Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity" (2020, Proceedings of the National Academy of Sciences)
  • "An engineered IL-2 partial agonist promotes CD8+ T cell stemness" (2021, Nature)
  • "BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells" (2021, Nature Immunology)
  • "Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy" (2024, Cell)

Gattinoni frequently collaborates with other researchers, including:

  • Eloise Scamardella
  • Enrico Lugli
  • Christoph Heuser
  • Gabriele De Simone
  • Emilia Maria Cristina Mazza

Best Publications

  • A human memory T cell subset with stem cell-like properties

    Luca Gattinoni;Enrico Lugli;Yun Ji;Zoltan Pos

  • Adoptive immunotherapy for cancer: building on success.

    Luca Gattinoni;Daniel J. Powell;Steven A. Rosenberg;Nicholas P. Restifo

  • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

    Luca Gattinoni;Steven E. Finkelstein;Christopher A. Klebanoff;Christopher A. Klebanoff;Paul A. Antony

  • Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

    Christopher A. Klebanoff;Luca Gattinoni;Parizad Torabi-Parizi;Keith Kerstann

  • Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

    Luca Gattinoni;Christopher A. Klebanoff;Christopher A. Klebanoff;Douglas C. Palmer;Claudia Wrzesinski

  • Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

    Luca Gattinoni;Xiao-Song Zhong;Douglas C Palmer;Yun Ji

  • Tumor-specific Th17-polarized cells eradicate large established melanoma

    Pawel Muranski;Andrea Boni;Paul A. Antony;Lydie Cassard

  • Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

    Madhusudhanan Sukumar;Jie Liu;Yun Ji;Murugan Subramanian

  • IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells

    Christopher A. Klebanoff;Steven E. Finkelstein;Deborah R. Surman;Michael K. Lichtman;Michael K. Lichtman

  • Paths to stemness: building the ultimate antitumour T cell

    Luca Gattinoni;Christopher A. Klebanoff;Nicholas P. Restifo

  • Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 + T cells via TLR4 signaling

    Chrystal M. Paulos;Claudia Wrzesinski;Andrew Kaiser;Christian S. Hinrichs

  • CD8+ T‐cell memory in tumor immunology and immunotherapy

    Christopher A. Klebanoff;Luca Gattinoni;Nicholas P. Restifo

  • The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.

    Tuoqi Wu;Yun Ji;E. Ashley Moseman;Haifeng C. Xu

  • T memory stem cells in health and disease

    Luca Gattinoni;Daniel E Speiser;Mathias Lichterfeld;Chiara Bonini

  • Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection.

    Chen Yao;Hong-Wei Sun;Neal E. Lacey;Yun Ji

  • IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.

    Christian S. Hinrichs;Rosanne Spolski;Chrystal M. Paulos;Luca Gattinoni

  • Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

    Pawel Muranski;Zachary A. Borman;Sid P. Kerkar;Christopher A. Klebanoff

  • Adoptively transferred effector cells derived from naïve rather than central memory CD8+ T cells mediate superior antitumor immunity

    Christian S. Hinrichs;Zachary A. Borman;Lydie Cassard;Luca Gattinoni

  • BACH2 represses effector programs to stabilize T reg -mediated immune homeostasis

    Rahul Roychoudhuri;Kiyoshi Hirahara;Kiyoshi Hirahara;Kambiz Mousavi;David Clever

  • Sorting through subsets: which T-cell populations mediate highly effective adoptive immunotherapy?

    Christopher A. Klebanoff;Luca Gattinoni;Nicholas P. Restifo

Frequent Co-Authors

Nicholas P. Restifo
Nicholas P. Restifo National Institutes of Health
Christopher A. Klebanoff
Christopher A. Klebanoff Memorial Sloan Kettering Cancer Center
Douglas C. Palmer
Douglas C. Palmer National Institutes of Health
Zhiya Yu
Zhiya Yu National Institutes of Health
Steven A. Rosenberg
Steven A. Rosenberg National Institutes of Health
Chrystal M. Paulos
Chrystal M. Paulos Emory University
Richard A. Morgan
Richard A. Morgan University of California, Los Angeles
Enrico Lugli
Enrico Lugli National Institutes of Health
John J. O'Shea
John J. O'Shea National Institutes of Health
Pamela L. Schwartzberg
Pamela L. Schwartzberg National Institutes of Health

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