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Immunology

D-Index
55
Citations
21594
World Ranking
3771
National Ranking
1728

Overview

Douglas C. Palmer is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on Oncology, Immunology, Molecular Biology, Pulmonary and Respiratory Medicine, and Cancer Research.

The scientist's work centers on topics such as Cancer Immunotherapy and Biomarkers, CAR-T cell therapy research, Immune Cell Function and Interaction, Immunotherapy and Immune Responses, CRISPR and Genetic Engineering, Immune cells in cancer, and T-cell and B-cell Immunology.

Recent publications include the following papers:

  • STING agonist promotes CAR T cell trafficking and persistence in breast cancer, 2020, The Journal of Experimental Medicine
  • Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies, 2020, Cancer Cell
  • Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade, 2022, Med
  • A T cell resilience model associated with response to immunotherapy in multiple tumor types, 2022, Nature Medicine
  • Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade, 2020, bioRxiv (Cold Spring Harbor Laboratory)

The scientist has frequently published in venues such as Regular and Young Investigator Award Abstracts, bioRxiv (Cold Spring Harbor Laboratory), Nature Medicine, Cancer Research, and SSRN Electronic Journal.

Prominent collaborators include Rigel J. Kishton, Scott A. Hammond, Nicholas P. Restifo, Devikala Gurusamy, and Suman K. Vodnala. These coauthors have worked with Douglas C. Palmer on multiple occasions, reflecting recurring collaborative efforts.

Best Publications

  • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

    Luca Gattinoni;Steven E. Finkelstein;Christopher A. Klebanoff;Christopher A. Klebanoff;Paul A. Antony

  • Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

    Christopher A. Klebanoff;Luca Gattinoni;Parizad Torabi-Parizi;Keith Kerstann

  • Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

    Luca Gattinoni;Christopher A. Klebanoff;Christopher A. Klebanoff;Douglas C. Palmer;Claudia Wrzesinski

  • Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells

    Willem W. Overwijk;Marc R. Theoret;Steven E. Finkelstein;Deborah R. Surman

  • Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells

    Luca Gattinoni;Xiao-Song Zhong;Douglas C Palmer;Yun Ji

  • Tumor-specific Th17-polarized cells eradicate large established melanoma

    Pawel Muranski;Andrea Boni;Paul A. Antony;Lydie Cassard

  • Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

    Madhusudhanan Sukumar;Jie Liu;Yun Ji;Murugan Subramanian

  • CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4 T helper cells and hindered by naturally occurring T regulatory cells.

    Paul A. Antony;Ciriaco A. Piccirillo;Akgül Akpinarli;Steven E. Finkelstein

  • IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells

    Christopher A. Klebanoff;Steven E. Finkelstein;Deborah R. Surman;Michael K. Lichtman;Michael K. Lichtman

  • Ionic immune suppression within the tumour microenvironment limits T cell effector function

    Robert Eil;Suman K. Vodnala;David Clever;Christopher A. Klebanoff;Christopher A. Klebanoff

  • Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 + T cells via TLR4 signaling

    Chrystal M. Paulos;Claudia Wrzesinski;Andrew Kaiser;Christian S. Hinrichs

  • Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy

    Christopher A. Klebanoff;Hung T. Khong;Paul A. Antony;Douglas C. Palmer

  • IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.

    Christian S. Hinrichs;Rosanne Spolski;Chrystal M. Paulos;Luca Gattinoni

  • T cell stemness and dysfunction in tumors are triggered by a common mechanism.

    Suman Kumar Vodnala;Robert Eil;Rigel J. Kishton;Madhusudhanan Sukumar

  • Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

    Pawel Muranski;Zachary A. Borman;Sid P. Kerkar;Christopher A. Klebanoff

  • Adoptively transferred effector cells derived from naïve rather than central memory CD8+ T cells mediate superior antitumor immunity

    Christian S. Hinrichs;Zachary A. Borman;Lydie Cassard;Luca Gattinoni

  • Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy

    Madhusudhanan Sukumar;Jie Liu;Gautam U. Mehta;Shashank J. Patel

  • Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics

    Joseph G. Crompton;Joseph G. Crompton;Joseph G. Crompton;Madhusudhanan Sukumar;Rahul Roychoudhuri;David Clever;David Clever

  • Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy

    Christian S. Hinrichs;Zachary A. Borman;Luca Gattinoni;Zhiya Yu

  • High-Efficiency Transfection of Primary Human and Mouse T Lymphocytes Using RNA Electroporation

    Yangbing Zhao;Zhili Zheng;Cyrille J. Cohen;Luca Gattinoni

  • MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer

    Jan C. Dudda;Bruno Salaun;Yun Ji;Douglas C. Palmer

Frequent Co-Authors

Nicholas P. Restifo
Nicholas P. Restifo National Institutes of Health
Luca Gattinoni
Luca Gattinoni University of Regensburg
Christopher A. Klebanoff
Christopher A. Klebanoff Memorial Sloan Kettering Cancer Center
Zhiya Yu
Zhiya Yu National Institutes of Health
Steven A. Rosenberg
Steven A. Rosenberg National Institutes of Health
Chrystal M. Paulos
Chrystal M. Paulos Emory University
Richard A. Morgan
Richard A. Morgan University of California, Los Angeles
Chi-Chao Chan
Chi-Chao Chan National Institutes of Health
Warren J. Leonard
Warren J. Leonard National Institutes of Health
Lawrence E. Samelson
Lawrence E. Samelson National Institutes of Health

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