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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
102
Citations
55387
World Ranking
1336
National Ranking
76

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

John D. Hayes is affiliated with the University of Dundee in the United Kingdom and focuses on research in the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also made in Medicine.

Their research emphasizes molecular biology, immunology, cancer research, surgery, and epidemiology. Hayes has published extensively on topics including genomics, phytochemicals, and oxidative stress, as well as glutathione transferases and polymorphisms. Other areas of study involve cancer, hypoxia, and metabolism, sulfur compounds in biology, histone deacetylase inhibitors research, autophagy in disease and therapy, and liver disease diagnosis and treatment.

Frequent publication venues for their work include:

  • Redox Biology
  • Free Radical Biology and Medicine
  • Cancer Cell
  • Cancers
  • Trends in Biochemical Sciences

Hayes has collaborated regularly with coauthors such as Albena T. Dinkova-Kostova, Sharadha Dayalan Naidu, Antonio Cuadrado, Raquel Fernández-Ginés, and Ana I. Rojo.

Recent papers authored or coauthored by John D. Hayes include:

  • Oxidative Stress in Cancer, 2020, Cancer Cell
  • NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis, 2020, Cancers
  • Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2, 2022, Free Radical Biology and Medicine
  • Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress, 2021, Redox Biology
  • Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis, 2025, Trends in Biochemical Sciences

The breadth of Hayes's research spans several biochemical processes and disease mechanisms, with a focus on how molecular pathways intersect with oxidative stress and cancer development. Their work on Nrf2 signaling pathways is reflected in multiple publications across various specialized journals.

Best Publications

  • The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.

    John D. Hayes;David J. Pulford

  • Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

    John D. Hayes;Lesley I. McLellan

  • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

    John D. Hayes;Albena T. Dinkova-Kostova

  • Oxidative Stress in Cancer.

    John D. Hayes;Albena T. Dinkova-Kostova;Albena T. Dinkova-Kostova;Kenneth D. Tew

  • p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.

    Ashish Jain;Trond Lamark;Eva Sjøttem;Kenneth Bowitz Larsen

  • Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

    Michael McMahon;Ken Itoh;Masayuki Yamamoto;John D. Hayes

  • Glutathione S-Transferase Polymorphisms and Their Biological Consequences

    John D. Hayes;Richard C. Strange

  • Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

    Antonio Cuadrado;Ana I. Rojo;Geoffrey Wells;John D. Hayes

  • NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

    John D. Hayes;Michael McMahon

  • The Cap ‘n’ Collar Basic Leucine Zipper Transcription Factor Nrf2 (NF-E2 p45-related Factor 2) Controls Both Constitutive and Inducible Expression of Intestinal Detoxification and Glutathione Biosynthetic Enzymes

    Michael McMahon;Ken Itoh;Masayuki Yamamoto;Simon A. Chanas

  • NOMENCLATURE FOR HUMAN GLUTATHIONE TRANSFERASES

    B Mannervik;Y C Awasthi;P G Board;J D Hayes

  • Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

    Lauren E. Tebay;Holly Robertson;Stephen T. Durant;Steven R. Vitale

  • SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

    Patricia Rada;Ana I. Rojo;Sudhir Chowdhry;Michael McMahon

  • Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.

    Christine Bonnesen;Ian M. Eggleston;John D. Hayes

  • Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

    Sudhir Chowdhry;Yiguo Zhang;Michael McMahon;Calum Sutherland

  • Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

    John D. Hayes;Michael McMahon;Sudhir Chowdhry;Albena T. Dinkova-Kostova

  • Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

    Paul Nioi;Michael McMahon;Ken Itoh;Masayuki Yamamoto

  • Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

    Simon A Chanas;Qing Jiang;Michael McMahon;Gail K McWalter

  • Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

    Antonio Cuadrado

  • Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress

    John D. Hayes;Richard C. Strange

Frequent Co-Authors

Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Albena T. Dinkova-Kostova
Albena T. Dinkova-Kostova University of Dundee
Richard C. Strange
Richard C. Strange Keele University
David J. Harrison
David J. Harrison University of St Andrews
C. Roland Wolf
C. Roland Wolf University of Dundee
Colin J. Henderson
Colin J. Henderson University of Dundee
Ken Itoh
Ken Itoh Hirosaki University
Michael L. J. Ashford
Michael L. J. Ashford University of Dundee
Peter C. Hayes
Peter C. Hayes University of Edinburgh
Giles E. Hardingham
Giles E. Hardingham University of Edinburgh

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