World's Best Scientists 2026 revealed!

D-Index & Metrics

Computer Science

D-Index
47
Citations
15115
World Ranking
6320
National Ranking
101

Overview

Stefan Klein is affiliated with Erasmus University Rotterdam in the Netherlands. Their primary research area lies within medicine, with a focus on radiology, nuclear medicine, and imaging. The scientist's work spans several subfields including surgery, biomedical engineering, artificial intelligence, and pulmonary and respiratory medicine.

The researcher has contributed notably to topics such as radiomics and machine learning in medical imaging, advanced neuroimaging techniques and applications, advanced MRI techniques and applications, dementia and cognitive impairment research, medical imaging techniques and applications, osteoarthritis treatment and mechanisms, and AI in cancer detection.

Recent publications by Stefan Klein highlight a diverse range of applications and studies in the field. These include:

  • "Combined molecular subtyping, grading, and segmentation of glioma using multi-task deep learning" (2022, Neuro-Oncology)
  • "FUTURE-AI: international consensus guideline for trustworthy and deployable artificial intelligence in healthcare" (2025, BMJ)
  • "Cross-cohort generalizability of deep and conventional machine learning for MRI-based diagnosis and prediction of Alzheimer's disease" (2021, Data Archiving and Networked Services (DANS))
  • "The Alzheimer's Disease Prediction Of Longitudinal Evolution (TADPOLE) Challenge: Results after 1 Year Follow-up" (2021, The Journal of Machine Learning for Biomedical Imaging)
  • "A machine learning approach to distinguish between knees without and with osteoarthritis using MRI-based radiomic features from tibial bone" (2021, European Radiology)

Stefan Klein regularly collaborates with several co-authors in their research. The most frequent co-authors include:

  • Wiro J. Niessen
  • Esther E. Bron
  • Martijn P. A. Starmans
  • Jacob J. Visser
  • Marion Smits

The researcher's work often appears in a variety of publication venues, some of which have hosted multiple publications over time. These venues include:

  • arXiv (Cornell University)
  • Osteoarthritis and Cartilage
  • Ultrasound in Obstetrics and Gynecology
  • Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
  • Medical Image Analysis

Stefan Klein has also authored contributions to book publications, including a work published by Cambridge University Press entitled Cambridge Handbook of Qualitative Digital Research (2023).

Best Publications

  • elastix : A Toolbox for Intensity-Based Medical Image Registration

    S. Klein;M. Staring;K. Murphy;M.A. Viergever

  • Fast parallel image registration on CPU and GPU for diagnostic classification of Alzheimer's disease.

    Denis P Shamonin;Esther E Bron;Boudewijn P.F. Lelieveldt;Marion Smits

  • Evaluation of Optimization Methods for Nonrigid Medical Image Registration Using Mutual Information and B-Splines

    S. Klein;M. Staring;J.P.W. Pluim

  • Automatic segmentation of the prostate in 3D MR images by atlas matching using localized mutual information.

    Stefan Klein;Uulke A. van der Heide;Irene M. Lips;Marco van Vulpen

  • Adaptive Stochastic Gradient Descent Optimisation for Image Registration

    Stefan Klein;Josien P. Pluim;Marius Staring;Max A. Viergever

  • Evaluation of Registration Methods on Thoracic CT: The EMPIRE10 Challenge

    K. Murphy;B. van Ginneken;J. M. Reinhardt;S. Kabus

  • Standardized evaluation of algorithms for computer-aided diagnosis of dementia based on structural MRI: The CADDementia challenge

    Esther E. Bron;Marion Smits;Wiesje M. van der Flier;Hugo Vrenken

  • A survey of medical image registration - under review

    Max A. Viergever;J.B. Antoine Maintz;Stefan Klein;Keelin Murphy

  • SimpleElastix: A User-Friendly, Multi-lingual Library for Medical Image Registration

    Kasper Marstal;Floris Berendsen;Marius Staring;Stefan Klein

  • Nonrigid registration of dynamic medical imaging data using nD + t B-splines and a groupwise optimization approach.

    C.T. Metz;S. Klein;M. Schaap;T. van Walsum

  • Changes in Normal-Appearing White Matter Precede Development of White Matter Lesions

    Marius de Groot;Benjamin F.J. Verhaaren;Renske de Boer;Stefan Klein

  • First supermodule of the MACRO detector at Gran Sasso

    S. Ahlen;M. Ambrosio;R. Antolini;G. Auriemma

  • Multimodal Machine Learning-based Knee Osteoarthritis Progression Prediction from Plain Radiographs and Clinical Data.

    Aleksei Tiulpin;Aleksei Tiulpin;Stefan Klein;Sita M. A. Bierma-Zeinstra;Jérôme Thevenot

  • Improving alignment in Tract-based spatial statistics: evaluation and optimization of image registration

    Marius de Groot;Meike W. Vernooij;Stefan Klein;M. Arfan Ikram

  • A rigidity penalty term for nonrigid registration

    Marius Staring;Stefan Klein;Josien P. W. Pluim

  • Adaptive local multi-atlas segmentation : Application to the heart and the caudate nucleus

    Eva M. van Rikxoort;Ivana Isgum;Yulia Arzhaeva;Marius Staring

  • PCA-based groupwise image registration for quantitative MRI.

    W. Huizinga;D.H.J. Poot;D.H.J. Poot;J.-M. Guyader;R. Klaassen

  • Trajectories of imaging markers in brain aging: the Rotterdam Study.

    Elisabeth J. Vinke;Marius de Groot;Vikram Venkatraghavan;Stefan Klein

  • Semi-automatic construction of reference standards for evaluation of image registration.

    K Murphy;van B Bram Ginneken;S Klein;M Staring

  • Registration of Cervical MRI Using Multifeature Mutual Information

    M. Staring;U.A. van der Heide;S. Klein;M.A. Viergever

  • Objective classification of residents based on their psychomotor laparoscopic skills.

    Magdalena K. Chmarra;Stefan Klein;Stefan Klein;Joost C. F. de Winter;Frank-Willem Jansen;Frank-Willem Jansen

  • Feature Selection Based on the SVM Weight Vector for Classification of Dementia

    Esther E. Bron;Marion Smits;Wiro J. Niessen;Stefan Klein

Frequent Co-Authors

Wiro J. Niessen
Wiro J. Niessen Erasmus University Rotterdam
Marius Staring
Marius Staring Leiden University Medical Center
Josien P. W. Pluim
Josien P. W. Pluim Eindhoven University of Technology
Marleen de Bruijne
Marleen de Bruijne Erasmus University Rotterdam
Meike W. Vernooij
Meike W. Vernooij Erasmus University Rotterdam
G. Giacomelli
G. Giacomelli University of Bologna
Paolo Giubellino
Paolo Giubellino National Institute for Nuclear Physics
F. Cafagna
F. Cafagna National Institute for Nuclear Physics
S. Coutu
S. Coutu Pennsylvania State University

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