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Biology and Biochemistry

D-Index
59
Citations
12480
World Ranking
12533
National Ranking
348

Overview

Paul Clarke is a researcher affiliated with the University of Queensland in Australia. Their work mainly spans the fields of Biochemistry, Genetics and Molecular Biology, with additional contributions in Engineering. The primary subfields of their research include Molecular Biology, Biomedical Engineering, Cancer Research, and Oncology.

The scientific topics covered by their publications emphasize DNA Repair Mechanisms, Nanopore and Nanochannel Transport Studies, and Cancer Genomics and Diagnostics. Other notable research themes involve Cancer-related gene regulation, Signaling Pathways in Disease, Protein Degradation and Inhibitors, as well as PARP inhibition in cancer therapy.

Among the recent papers authored or co-authored by Paul Clarke are:

  • A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells, 2022, published in bioRxiv (Cold Spring Harbor Laboratory)
  • Keep it focused: PRMT6 drives the localization of RCC1 to chromosomes to facilitate mitosis, cell proliferation, and tumorigenesis, 2021, published in Molecular Cell
  • A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells, 2025, published in Nature Communications

Paul Clarke frequently collaborates with several scientists, including:

  • Mathew V. Jones
  • Subash Kumar
  • Pauline L. Pfuderer
  • Alexis Bonfim-Melo
  • Julia K. Pagan

Their work is disseminated across different publication venues with recent papers appearing in bioRxiv (Cold Spring Harbor Laboratory), Molecular Cell, and Nature Communications.

Best Publications

  • Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis

    I Hoffmann;P R Clarke;M J Marcote;E Karsenti

  • Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

    Lindsey A. Allan;Nick Morrice;Suzanne Brady;Gareth Magee

  • Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities.

    David Carling;Paul R. Clarke;Victor A. Zammit;D. Grahame Hardie

  • Spatial and temporal coordination of mitosis by Ran GTPase.

    Paul R. Clarke;Chuanmao Zhang

  • Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver.

    P. R. Clarke;D. G. Hardie

  • Phosphorylation of Mcl‐1 by CDK1–cyclin B1 initiates its Cdc20‐dependent destruction during mitotic arrest

    Margaret E Harley;Lindsey A Allan;Helen S Sanderson;Paul R Clarke

  • Randomized Trial of Platelet-Transfusion Thresholds in Neonates.

    Curley A;Stanworth Sj;Willoughby K;Fustolo-Gunnink Sf

  • Phosphorylation of Caspase-9 by CDK1/Cyclin B1 Protects Mitotic Cells against Apoptosis

    Lindsey A. Allan;Paul R. Clarke

  • Apoptosis and autophagy: Regulation of caspase‐9 by phosphorylation

    Lindsey A. Allan;Paul R. Clarke

  • Chromatin-Independent Nuclear Envelope Assembly Induced by Ran GTPase in Xenopus Egg Extracts

    Chuanmao Zhang;Chuanmao Zhang;Paul R. Clarke

  • Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts.

    Paul R. Clarke;Ingrid Hoffmann;Giulio Draetta;Eric Karsenti

  • Regulation of apoptosis by BH3 domains in a cell-free system

    Sabina C Cosulich;Vivienne Worrall;Philip J Hedge;Stephen Green

  • Bcl-2 regulates a caspase-3/caspase-2 apoptotic cascade in cytosolic extracts.

    Eileithyia Swanton;Peter Savory;Sabina Cosulich;Paul Clarke;Paul Clarke

  • Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts

    Chuanmao Zhang;Mike Hughes;Paul R. Clarke

  • Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

    Darko Curman;Bruno Cinel;David E. Williams;Natalie Rundle

  • Cell-cycle control in the face of damage--a matter of life or death.

    Paul R. Clarke;Lindsey A. Allan

  • Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study.

    Cristina Alcon-Giner;Matthew J. Dalby;Shabhonam Caim;Jennifer Ketskemety

  • Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle?

    Paul R Clarke;Chuanmao Zhang;Chuanmao Zhang

  • DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

    Anne Seifert;Lindsey A. Allan;Paul R. Clarke

  • DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system

    Catriona A. L. Clarke;Paul R. Clarke

Frequent Co-Authors

Paul T. Heath
Paul T. Heath St George's, University of London
Lesley Hoyles
Lesley Hoyles Nottingham Trent University
Eric Karsenti
Eric Karsenti École Normale Supérieure
Simon J. Stanworth
Simon J. Stanworth NHS Blood and Transplant
Mark A. Webber
Mark A. Webber University of East Anglia
Seetha Shankaran
Seetha Shankaran Wayne State University
Shamez N. Ladhani
Shamez N. Ladhani UK Health Security Agency
Giulio Draetta
Giulio Draetta The University of Texas MD Anderson Cancer Center
Andrew J. Pollard
Andrew J. Pollard University of Oxford
Wendy Hardeman
Wendy Hardeman University of East Anglia

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