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Iain W. Mattaj

Iain W. Mattaj

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Molecular Biology
Italy
2026
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Biology and Biochemistry
Italy
2025

D-Index & Metrics

Molecular Biology

D-Index
106
Citations
34750
World Ranking
433
National Ranking
7

Biology and Biochemistry

D-Index
106
Citations
34774
World Ranking
1163
National Ranking
14

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Italy Leader Award
  • 2025 - Research.com Biology and Biochemistry in Italy Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2017 - Member of the National Academy of Sciences
  • 2005 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Genetics/Molecular Biology and Cell Biology
  • 2002 - Fellow of the American Academy of Arts and Sciences
  • 2000 - Fellow of the Royal Society of Edinburgh
  • 1999 - Member of Academia Europaea
  • 1999 - Fellow of the Royal Society, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Iain W. Mattaj is affiliated with Human Technopole in Italy and specializes in research primarily within the fields of Biochemistry, Genetics, and Molecular Biology. Their work encompasses several subfields, including Molecular Biology, Cancer Research, Epidemiology, Immunology, and Ecology, Evolution, Behavior, and Systematics.

Their research covers a variety of main topics, reflecting a broad approach to biomedical and environmental sciences. These topics include Bioinformatics and Genomic Networks, Cancer Genomics and Diagnostics, Epigenetics and DNA Methylation, Herpesvirus Infections and Treatments, Toxin Mechanisms and Immunotoxins, Vector-Borne Animal Diseases, as well as Health, Environment, and Cognitive Aging.

Recent publications highlight contributions across several specialized areas. These include:

  • Highlights from the 1st European cancer dependency map symposium and workshop, 2023, published in FEBS Letters
  • Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway, 2023, published in The EMBO Journal
  • Goodbye John, 2021, published in The EMBO Journal

Frequent publication venues for their work are as follows:

  • The EMBO Journal
  • FEBS Letters

The scientist often collaborates with a range of coauthors, including Lucia Trastulla, Aurora Savino, Pedro Beltrão, Isidro Cortés-Ciriano, and Peter Fenici, each contributing to various aspects of the research projects undertaken.

Iain W. Mattaj has been recognized by several academic and scientific institutions. Their awards and honors include:

  • Member of the National Academy of Sciences (2017)
  • German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften for Genetics/Molecular Biology and Cell Biology (2005)
  • Fellow of the American Academy of Arts and Sciences (2002)
  • Fellow of the Royal Society of Edinburgh (2000)
  • Fellow of the Royal Society, United Kingdom (1999)
  • Member of Academia Europaea (1999)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • CRM1 Is an Export Receptor for Leucine-Rich Nuclear Export Signals

    Maarten Fornerod;Mutsuhito Ohno;Minoru Yoshida;Iain W. Mattaj

  • Nucleocytoplasmic Transport: The Soluble Phase

    Iain W. Mattaj;Ludwig Englmeier

  • The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus

    Elisa Izaurralde;Ulrike Kutay;Cayetano von Kobbe;Iain W. Mattaj

  • Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity

    Oliver J Gruss;Rafael E Carazo-Salas;Christoph A Schatz;Giulia Guarguaglini

  • A nuclear cap binding protein complex involved in pre-mRNA splicing

    Elisa Izaurralde;Joe Lewis;Caroline McGuigan;Marzena Jankowska

  • Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

    Rafael E. Carazo-Salas;Giulia Guarguaglini;Oliver J. Gruss;Alexandra Segref

  • Monomethylated cap structures facilitate RNA export from the nucleus.

    Jörg Hamm;Iain W. Mattaj

  • Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex.

    U. Kutay;E. Izaurralde;F. R. Bischoff;I. W. Mattaj

  • PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation.

    Mutsuhito Ohno;Alexandra Segref;Angela Bachi;Matthias Wilm

  • Nucleocytoplasmic Transport: The Last 200 Nanometers

    Mutsuhito Ohno;Maarten Fornerod;Iain W Mattaj

  • Cap trimethylation of U snRNA is cytoplasmic and dependent on U snRNP protein binding.

    Iain W. Mattaj

  • The Conserved Nup107-160 Complex Is Critical for Nuclear Pore Complex Assembly

    Tobias C Walther;Annabelle Alves;Helen Pickersgill;Isabelle Loïodice

  • A cap-binding protein complex mediating U snRNA export

    Elisa Izaurralde;Joe Lewis;Chiara Gamberi;Artur Jarmolowski

  • Nuclear export of different classes of RNA is mediated by specific factors

    Artur Jarmolowski;Wilbert C. Boelens;Elisa Izaurralde;Iain W. Mattaj

  • Identification of hSRP1α as a Functional Receptor for Nuclear Localization Sequences

    Karsten Weis;Iain W. Mattaj;Angus I. Lamond

  • U1 snRNP Inhibits Pre-mRNA Polyadenylation through a Direct Interaction between U1 70K and Poly(A) Polymerase

    Samuel I Gunderson;Maria Polycarpou-Schwarz;Iain W Mattaj

  • Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly

    Martin Hetzer;Hemmo H. Meyer;Tobias C. Walther;Daniel Bilbao-Cortes

  • Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA.

    D. Scherly;W. Boelens;W.J. van Venrooij;N.A. Dathan

  • Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells

    Oliver J Gruss;Malte Wittmann;Hideki Yokoyama;Rainer Pepperkok

  • Pushing the envelope: structure, function, and dynamics of the nuclear periphery.

    Martin W Hetzer;Tobias C Walther;Iain W Mattaj

Frequent Co-Authors

Elisa Izaurralde
Elisa Izaurralde Max Planck Institute for Developmental Biology
Wilbert C. Boelens
Wilbert C. Boelens Radboud University
Matthias Wilm
Matthias Wilm University College Dublin
Martin W. Hetzer
Martin W. Hetzer Salk Institute for Biological Studies
Maarten Fornerod
Maarten Fornerod Erasmus University Rotterdam
Eric Karsenti
Eric Karsenti École Normale Supérieure
Tobias C. Walther
Tobias C. Walther Harvard University
Stephen Cusack
Stephen Cusack European Bioinformatics Institute
W. J. Van Venrooij
W. J. Van Venrooij Radboud University
Dirk Görlich
Dirk Görlich Max Planck Society

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