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Tobias C. Walther

Tobias C. Walther

D-Index & Metrics

Molecular Biology

D-Index
76
Citations
35448
World Ranking
1130
National Ranking
586

Overview

Tobias C. Walther is a researcher affiliated with Harvard University in the United States. Their work spans across key areas within biochemistry, genetics, molecular biology, and medicine. Walther's research focuses particularly on molecular biology, biochemistry, cell biology, physiology, and neurology.

The scientist has contributed extensively to topics such as lipid metabolism and biosynthesis, endoplasmic reticulum stress and disease, photosynthetic processes and mechanisms, cellular transport and secretion, lysosomal storage disorders research, autophagy in disease and therapy, and pancreatic function and diabetes.

Walther's recent publications include the following:

  • Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency, 2020, Nature
  • An open-access volume electron microscopy atlas of whole cells and tissues, 2021, Nature
  • Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression, 2020, Molecular Cell
  • Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme, 2020, Nature
  • Seipin forms a flexible cage at lipid droplet formation sites, 2022, Nature Structural & Molecular Biology

Their frequently collaborating co-authors include Robert V. Farese, Yohannes A. Ambaw, Zon Weng Lai, Sebastian Boland, and Chandramohan Chitraju.

Walther's work is published in various scientific journals, with a concentration of publications in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Communications
  • eLife
  • Nature Cell Biology

Best Publications

  • Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

    Chuna Ram Choudhary;Chanchal Kumar;Florian Gnad;Michael L Nielsen

  • Cellular fatty acid metabolism and cancer

    Erin Currie;Almut Schulze;Rudolf Zechner;Tobias C. Walther

  • Lipid Droplets and Cellular Lipid Metabolism

    Tobias C. Walther;Robert V. Farese

  • The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

    Agnes Roczniak-Ferguson;Constance S. Petit;Florian Froehlich;Sharon Qian

  • Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

    Robert V. Farese;Tobias C. Walther

  • Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast.

    Lyris M. F. de Godoy;Jesper V. Olsen;Jürgen Cox;Michael L. Nielsen

  • The biophysics and cell biology of lipid droplets

    Abdou Rachid Thiam;Robert V. Farese;Tobias C. Walther

  • Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

    Florian Wilfling;Huajin Wang;Joel T. Haas;Natalie Krahmer

  • Introducing the CTA concept

    B. S. Acharya;M. Actis;T. Aghajani;G. Agnetta

  • Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

    Yi Guo;Tobias C. Walther;Meghana Rao;Nico Stuurman

  • Lipid Droplet Biogenesis.

    Tobias C. Walther;Jeeyun Chung;Robert V. Farese;Robert V. Farese

  • Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation

    Ariel A Bazzini;Timothy G Johnstone;Romain Christiano;Sebastian D Mackowiak

  • The life of lipid droplets

    Tobias C. Walther;Robert V. Farese

  • Lipid droplets and liver disease: from basic biology to clinical implications

    Nina L. Gluchowski;Michel Becuwe;Tobias C. Walther;Robert V. Farese

  • Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

    Natalie Krahmer;Yi Guo;Florian Wilfling;Maximiliane Hilger

  • Mass spectrometry–based proteomics in cell biology

    Tobias C. Walther;Matthias Mann

  • Balancing the fat: lipid droplets and human disease.

    Natalie Krahmer;Robert V. Farese;Tobias C. Walther

  • Lipid droplets at a glance

    Yi Guo;Kimberly R. Cordes;Robert V. Farese;Tobias C. Walther

  • The Conserved Nup107-160 Complex Is Critical for Nuclear Pore Complex Assembly

    Tobias C Walther;Annabelle Alves;Helen Pickersgill;Isabelle Loïodice

  • Lipid Droplet Biogenesis

    Florian Wilfling;Joel T Haas;Tobias C Walther;Robert V Farese

Frequent Co-Authors

Robert V. Farese
Robert V. Farese Harvard University
Peter Walter
Peter Walter University of California, San Francisco
Matthias Mann
Matthias Mann Max Planck Institute of Biochemistry
Iain W. Mattaj
Iain W. Mattaj Human Technopole
Martin W. Hetzer
Martin W. Hetzer Salk Institute for Biological Studies
Eric J. Huang
Eric J. Huang University of California, San Francisco
Jesper V. Olsen
Jesper V. Olsen University of Copenhagen
Lucy Fortson
Lucy Fortson University of Minnesota
S. Mereghetti
S. Mereghetti National Institute for Astrophysics
Kunihito Ioka
Kunihito Ioka Kyoto University

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