World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
115
Citations
64456
World Ranking
300
National Ranking
180

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Yue Xiong is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with significant contributions in Medicine. Within these broader fields, they have delved extensively into subfields such as Molecular Biology, Cancer Research, Immunology, Epidemiology, and Biomedical Engineering.

The major topics covered in Yue Xiong's work include:

  • Ubiquitin and proteasome pathways
  • Extracellular vesicles in disease
  • Epigenetics and DNA Methylation
  • Protein Degradation and Inhibitors
  • Cancer, Hypoxia, and Metabolism
  • RNA modifications and cancer
  • Liver Disease Diagnosis and Treatment

Yue Xiong has published numerous papers in various reputable venues. Frequent publication platforms include:

  • Science Advances
  • UNC Libraries
  • Frontiers in Cell and Developmental Biology
  • Chemical Engineering Journal
  • Journal of Medicinal Chemistry

Recent notable publications by Yue Xiong are:

  • "Advancing targeted protein degradation for cancer therapy," 2021, Nature reviews. Cancer
  • "Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity," 2020, Liver International
  • "Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses," 2022, Nature Cell Biology
  • "Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders," 2020, Journal of Medicinal Chemistry
  • "Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis," 2022, Journal of Hepatology

Collaboration forms an important aspect of Yue Xiong's scientific activity. Frequent co-authors include Kun-Liang Guan, Yiping Sun, Dan Ye, Wenbin Deng, and Jian Jin.

Yue Xiong was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • p21 is a universal inhibitor of cyclin kinases

    Yue Xiong;Gregory J. Hannon;Gregory J. Hannon;Hui Zhang;Hui Zhang;David Casso;David Casso

  • Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

    Wei Xu;Hui Yang;Ying Liu;Ying Yang

  • Regulation of cellular metabolism by protein lysine acetylation.

    Shimin Zhao;Wei Xu;Wenqing Jiang;Wei Yu

  • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.

    Yanping Zhang;Yue Xiong;Wendell G Yarbrough

  • Origin and evolution of retroelements based upon their reverse transcriptase sequences.

    Yue Xiong;T. H. Eickbush

  • D Type Cyclins Associate with Multiple Protein Kinases and the DNA Replication and Repair Factor PCNA

    Yue Xiong;Hui Zhang;David Beach

  • Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

    Shimin Zhao;Yan Lin;Wei Xu;Wenqing Jiang

  • Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

    Tiffany Hung;Yulei Wang;Michael F. Lin;Michael F. Lin;Ashley K. Koegel

  • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

    D A Alcorta;Y Xiong;D Phelps;G Hannon

  • Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

    Michael B. Datto;Yan Li;Joanne F. Panus;David J. Howe

  • Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux.

    Qijun Wang;Yakun Zhang;Chen Yang;Hui Xiong;Hui Xiong

  • Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene.

    Y Kotake;T Nakagawa;K Kitagawa;S Suzuki

  • Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

    Mengtao Xiao;Hui Yang;Wei Xu;Shenghong Ma

  • Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

    K L Guan;C W Jenkins;Y Li;M A Nichols

  • TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

    Qun Ying Lei;Heng Zhang;Bin Zhao;Zheng Yu Zha

  • Human D-type cyclin

    Yue Xiong;Tim Connolly;Bruce Futcher;David Beach

  • BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.

    Manabu Furukawa;Yue Xiong

  • Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

    Yue Xiong;Hui Zhang;David Beach

  • Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway.

    Yanping Zhang;Gabrielle White Wolf;Krishna P Bhat;Aiwen Jin

  • Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

    Yang H;Liu Y;Bai F;Zhang Jy

Frequent Co-Authors

Kun-Liang Guan
Kun-Liang Guan Westlake University
Qun-Ying Lei
Qun-Ying Lei Fudan University
David Beach
David Beach Cold Spring Harbor Laboratory
Yan Lin
Yan Lin Shanghai Jiao Tong University
Thomas H. Eickbush
Thomas H. Eickbush University of Rochester
Xian Chen
Xian Chen University of North Carolina at Chapel Hill
Lishan Su
Lishan Su University of Maryland, Baltimore
Jun Yao
Jun Yao China University of Petroleum, Beijing
Yi Zhang
Yi Zhang Harvard University
Gregory J. Hannon
Gregory J. Hannon University of Cambridge

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