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Molecular Biology

D-Index
69
Citations
27920
World Ranking
1447
National Ranking
735

Overview

Xian Chen is a researcher affiliated with the University of North Carolina at Chapel Hill in the United States. Their work spans several areas within biochemistry, genetics, molecular biology, and medicine, with a strong focus on molecular biology and oncology.

The primary fields of study for Xian Chen include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broader fields, their research further specializes in subfields such as:

  • Molecular Biology
  • Oncology
  • Immunology
  • Spectroscopy
  • Genetics

The main topics of Xian Chen's work cover a range of areas related to protein regulation and cancer biology, including:

  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer
  • Peptidase Inhibition and Analysis
  • Histone Deacetylase Inhibitors Research
  • Cancer-related gene regulation
  • Epigenetics and DNA Methylation

Several recent publications reflect the scope of their research:

  • Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy, 2020, Cell
  • Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis, 2020, Nature
  • TF-PROTACs Enable Targeted Degradation of Transcription Factors, 2021, Journal of the American Chemical Society
  • Icariin-induced inhibition of SIRT6/NF-κB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer, 2020, Cancer Science
  • AIM2 in regulatory T cells restrains autoimmune diseases, 2021, Nature

Xian Chen has collaborated frequently with several coauthors, including:

  • Jian Jin
  • Ling Xie
  • Yan Xiong

The researcher's publications often appear in specific venues, highlighting their consistent contributions to certain scientific journals and platforms:

  • UNC Libraries
  • Journal of the American Chemical Society
  • Journal of Medicinal Chemistry
  • Nature
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Landscape of transcription in human cells

    Sarah Djebali;Carrie A. Davis;Angelika Merkel;Alex Dobin

  • An integrated encyclopedia of DNA elements in the human genome

    Ian Dunham;Anshul Kundaje;Shelley F. Aldred;Patrick J. Collins

  • Regulation of cellular metabolism by protein lysine acetylation.

    Shimin Zhao;Wei Xu;Wenqing Jiang;Wei Yu

  • A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

    Richard M. Myers;John Stamatoyannopoulos;Michael Snyder;Ian Dunham

  • Proteogenomic characterization of human colon and rectal cancer

    Bing Zhang;Jing Wang;Xiaojing Wang;Jing Zhu

  • Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

    Hui Zhang;Tao Liu;Zhen Zhang;Samuel H. Payne

  • Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.

    Suhas Vasaikar;Chen Huang;Xiaojing Wang;Vladislav A. Petyuk

  • Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis.

    Feihua Wu;Yuan Chi;Yuan Chi;Yuan Chi;Zhonghao Jiang;Zhonghao Jiang;Yuanyuan Xu

  • Long noncoding RNAs are rarely translated in two human cell lines

    Balázs Bánfai;Hui Jia;Jainab Khatun;Emily Wood

  • The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

    Yu Lei;Haitao Wen;Yanbao Yu;Debra J. Taxman

  • Mycobacterium tuberculosis Functional Network Analysis by Global Subcellular Protein Profiling

    Kwasi G. Mawuenyega;Christian V. Forst;Karen M. Dobos;John T. Belisle

  • Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications

    Xian Chen;S. V. Santhana Mariappan;P. Catasti;R. Ratliff

  • Amino acid residue specific stable isotope labeling for quantitative proteomics

    Haining Zhu;Songqin Pan;Sheng Gu;E. Morton Bradbury;E. Morton Bradbury

  • Comprehensive Proteomic Profiling of the Membrane Constituents of a Mycobacterium tuberculosis Strain

    Sheng Gu;Jin Chen;Karen M. Dobos;E. Morton Bradbury;E. Morton Bradbury

  • GAA Instability in Friedreich's Ataxia Shares a Common, DNA-Directed and Intraallelic Mechanism with Other Trinucleotide Diseases

    A.Marquis Gacy;Geoffrey M Goellner;Craig Spiro;Xian Chen

  • Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry–Based Assays

    Andrew N. Hoofnagle;Jeffrey R. Whiteaker;Steven A. Carr;Eric Kuhn

  • Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats.

    Craig Spiro;Richard Pelletier;Michael L Rolfsmeier;Michael J Dixon

  • Structural Characterization of Formaldehyde-Induced Cross-Links Between Amino Acids and Deoxynucleosides and Their Oligomers

    Kun Lu;Wenjie Ye;Li Zhou;Leonard B. Collins

  • Structure–Function Correlations of the Insulin-linked Polymorphic Region

    Paolo Catasti;Xian Chen;Robert K. Moyzis;E.Morton Bradbury

  • Site-Specific Mass Tagging with Stable Isotopes in Proteins for Accurate and Efficient Protein Identification

    Xian Chen;and Lloyd M. Smith;E. Morton Bradbury

Frequent Co-Authors

E. Morton Bradbury
E. Morton Bradbury University of California, Davis
Matthew J. Ellis
Matthew J. Ellis Baylor College of Medicine
Steven A. Carr
Steven A. Carr Broad Institute
Pengyuan Yang
Pengyuan Yang Fudan University
Richard D. Smith
Richard D. Smith Pacific Northwest National Laboratory
Daniel W. Chan
Daniel W. Chan Johns Hopkins University School of Medicine
daniel c liebler
daniel c liebler Vanderbilt University
Amanda G. Paulovich
Amanda G. Paulovich Fred Hutchinson Cancer Research Center
Tao Liu
Tao Liu Pacific Northwest National Laboratory
David Fenyö
David Fenyö New York University

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