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Constantine S. Mitsiades

Constantine S. Mitsiades

D-Index & Metrics

Medicine

D-Index
106
Citations
48052
World Ranking
6448
National Ranking
3428

Research.com Recognitions

  • 2021 - Member of the American Society for Clinical Investigation
  • 2020 - Member of the American Society for Clinical Investigation
  • 2019 - Member of the American Society for Clinical Investigation
  • 2018 - Member of the American Society for Clinical Investigation
  • 2017 - Member of the American Society for Clinical Investigation
  • 2016 - Member of the American Society for Clinical Investigation
  • 2015 - Member of the American Society for Clinical Investigation
  • 2014 - Member of the American Society for Clinical Investigation
  • 2013 - Member of the American Society for Clinical Investigation
  • 2012 - Member of the American Society for Clinical Investigation
  • 2011 - Member of the American Society for Clinical Investigation
  • 2010 - Member of the American Society for Clinical Investigation
  • 2009 - Member of the American Society for Clinical Investigation
  • 2008 - Member of the American Society for Clinical Investigation
  • 2007 - Member of the American Society for Clinical Investigation
  • 2006 - Member of the American Society for Clinical Investigation
  • 2005 - Member of the American Society for Clinical Investigation
  • 2004 - Member of the American Society for Clinical Investigation
  • 2003 - Member of the American Society for Clinical Investigation
  • 2002 - Member of the American Society for Clinical Investigation
  • 2001 - Member of the American Society for Clinical Investigation
  • 2000 - Member of the American Society for Clinical Investigation
  • 1999 - Member of the American Society for Clinical Investigation
  • 1998 - Member of the American Society for Clinical Investigation
  • 1997 - Member of the American Society for Clinical Investigation
  • 1996 - Member of the American Society for Clinical Investigation
  • 1995 - Member of the American Society for Clinical Investigation
  • 1993 - Member of the American Society for Clinical Investigation
  • 1992 - Member of the American Society for Clinical Investigation

Overview

Constantine S. Mitsiades is affiliated with Harvard University in the United States. Their research spans multiple main fields of study including Biochemistry, Genetics and Molecular Biology, and Medicine. Subfields of study prominently featured in their work include Molecular Biology, Hematology, Immunology, Oncology, and Cancer Research.

The scientist has contributed to a variety of topics, notably:

  • Multiple Myeloma Research and Treatments
  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Immune Cell Function and Interaction
  • Histone Deacetylase Inhibitors Research
  • T-cell and B-cell Immunology
  • Cancer Mechanisms and Therapy

Frequent publication venues for their work include:

  • Blood
  • Cancer Research
  • Clinical Lymphoma Myeloma & Leukemia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Medicine

Notable recent papers are:

  • "An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence," 2021, Cancer Cell
  • "Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence," 2021, Cancer Discovery
  • "Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins," 2021, Cell Reports
  • "Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1," 2022, Nature Cancer
  • "Genome-scale screens identify factors regulating tumor cell responses to natural killer cells," 2021, Nature Genetics

Frequent co-authors include:

  • Ricardo de Matos Simoes
  • Ryosuke Shirasaki
  • Olga Dashevsky
  • Michal Sheffer
  • Sara Gandolfi

Throughout their career, Constantine S. Mitsiades has been consistently recognized as a Member of the American Society for Clinical Investigation, with memberships recorded annually from 1992 through 2021.

Best Publications

  • BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

    Jake E. Delmore;Ghayas C. Issa;Madeleine E. Lemieux;Peter B. Rahl

  • The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

    Gang Lu;Richard E. Middleton;Huahang Sun;MarkVic Naniong

  • NF-κB as a Therapeutic Target in Multiple Myeloma *

    Teru Hideshima;Dharminder Chauhan;Paul Richardson;Constantine Mitsiades

  • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets

    Teru Hideshima;Constantine Mitsiades;Giovanni Tonon;Paul G. Richardson

  • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma

    Paul G. Richardson;Robert L. Schlossman;Robert L. Schlossman;Edie Weller;Edie Weller;Teru Hideshima;Teru Hideshima

  • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma.

    Paul G. Richardson;Edie Weller;Sagar Lonial;Andrzej J. Jakubowiak

  • Molecular sequelae of proteasome inhibition in human multiple myeloma cells

    Nicholas Mitsiades;Constantine S. Mitsiades;Vassiliki Poulaki;Dharminder Chauhan

  • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.

    Nicholas Mitsiades;Constantine S. Mitsiades;Paul G. Richardson;Vassiliki Poulaki

  • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

    Nicholas Mitsiades;Constantine S. Mitsiades;Vassiliki Poulaki;Dharminder Chauhan

  • Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

    Nicholas Kwiatkowski;Tinghu Zhang;Peter B. Rahl;Brian J Abraham

  • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

    Dharminder Chauhan;Laurence Catley;Guilan Li;Klaus Podar

  • Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

    Constantine S Mitsiades;Nicholas S Mitsiades;Nicholas S Mitsiades;Ciaran J McMullan;Vassiliki Poulaki;Vassiliki Poulaki

  • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

    Teru Hideshima;Constantine Mitsiades;Masaharu Akiyama;Toshiaki Hayashi

  • Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications

    Constantine S. Mitsiades;Nicholas S. Mitsiades;Ciaran J. McMullan;Vassiliki Poulaki

  • Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

    Teru Hideshima;Laurence Catley;Hiroshi Yasui;Kenji Ishitsuka

  • Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

    Triona Ni Chonghaile;Kristopher A. Sarosiek;Thanh Trang Vo;Jeremy A. Ryan

  • A randomized phase 2 study of lenalidomide therapy for patients with relapsed or relapsed and refractory multiple myeloma

    Paul G. Richardson;Emily Blood;Constantine S. Mitsiades;Sundar Jagannath

  • Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.

    Richard LeBlanc;Laurence P Catley;Teru Hideshima;Suzanne Lentzsch

  • Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.

    Constantine S Mitsiades;Nicholas Mitsiades;Vassiliki Poulaki;Robert Schlossman

  • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

    Klaus Podar;Yu-Tzu Tai;Faith E. Davies;Suzanne Lentzsch

Frequent Co-Authors

Paul G. Richardson
Paul G. Richardson Harvard University
Kenneth C. Anderson
Kenneth C. Anderson Harvard University
Nikhil C. Munshi
Nikhil C. Munshi Harvard University
Teru Hideshima
Teru Hideshima Harvard University
Nicholas Mitsiades
Nicholas Mitsiades Baylor College of Medicine
Dharminder Chauhan
Dharminder Chauhan Harvard University
Robert L. Schlossman
Robert L. Schlossman Harvard University
Noopur Raje
Noopur Raje Harvard University
Irene M. Ghobrial
Irene M. Ghobrial Harvard University
Klaus Podar
Klaus Podar Karl Landsteiner University of Health Sciences

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