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Medicine

D-Index
83
Citations
29600
World Ranking
15476
National Ranking
7806

Overview

Nicholas Mitsiades is affiliated with Baylor College of Medicine in the United States. Their research primarily focuses on medical and molecular biology fields with significant contributions to oncology and pulmonary medicine. Mitsiades's work intersects areas such as prostate cancer treatment and research, cancer genomics and diagnostics, and the study of epigenetics and DNA methylation.

Their recent publications reflect a strong emphasis on cancer biology and therapeutics. Notable papers include:

  • Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment, 2021, Nature Communications
  • Racial disparities in prostate cancer: A complex interplay between socioeconomic inequities and genomics, 2022, Cancer Letters
  • The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response, 2022, Cancer Research
  • Androgen receptor signaling inhibitors: post-chemotherapy, pre-chemotherapy and now in castration-sensitive prostate cancer, 2021, Endocrine Related Cancer
  • Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP, 2020, Journal of Medicinal Chemistry

Frequent co-authors collaborating with Mitsiades include Salma Kaochar, Mamta Parikh, Heidi Dowst, Michael E. Scheurer, and Martha P. Mims.

The scientist has published extensively in several venues, particularly in:

  • Cancer Research
  • Journal of Clinical Oncology
  • The Journal of Urology
  • Proceedings of the National Academy of Sciences
  • Endocrine Related Cancer

Nicholas Mitsiades's main fields of study are Medicine and Biochemistry, Genetics, and Molecular Biology. They have contributed notably in subfields such as Pulmonary and Respiratory Medicine, Molecular Biology, Cancer Research, Oncology, and Radiology, Nuclear Medicine and Imaging.

Their work covers a variety of specialized topics, including:

  • Prostate Cancer Treatment and Research
  • Cancer Genomics and Diagnostics
  • Prostate Cancer Diagnosis and Treatment
  • PARP inhibition in cancer therapy
  • Epigenetics and DNA Methylation
  • Cancer Immunotherapy and Biomarkers
  • Protein Degradation and Inhibitors

Best Publications

  • Integrative genomic profiling of human prostate cancer

    Barry S. Taylor;Nikolaus Schultz;Haley Hieronymus;Anuradha Gopalan

  • NF-κB as a Therapeutic Target in Multiple Myeloma *

    Teru Hideshima;Dharminder Chauhan;Paul Richardson;Constantine Mitsiades

  • Molecular sequelae of proteasome inhibition in human multiple myeloma cells

    Nicholas Mitsiades;Constantine S. Mitsiades;Vassiliki Poulaki;Dharminder Chauhan

  • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.

    Nicholas Mitsiades;Constantine S. Mitsiades;Paul G. Richardson;Vassiliki Poulaki

  • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

    Nicholas Mitsiades;Constantine S. Mitsiades;Vassiliki Poulaki;Dharminder Chauhan

  • Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

    Constantine S Mitsiades;Nicholas S Mitsiades;Nicholas S Mitsiades;Ciaran J McMullan;Vassiliki Poulaki;Vassiliki Poulaki

  • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

    Teru Hideshima;Constantine Mitsiades;Masaharu Akiyama;Toshiaki Hayashi

  • Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression.

    Antonia M. Joussen;Vassiliki Poulaki;Nicholas Mitsiades;Bernd Kirchhof

  • Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications

    Constantine S. Mitsiades;Nicholas S. Mitsiades;Ciaran J. McMullan;Vassiliki Poulaki

  • Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.

    Richard LeBlanc;Laurence P Catley;Teru Hideshima;Suzanne Lentzsch

  • Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.

    Constantine S Mitsiades;Nicholas Mitsiades;Vassiliki Poulaki;Robert Schlossman

  • Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity.

    Nicholas Mitsiades;Wei-hsuan Yu;Vassiliki Poulaki;Maria Tsokos

  • TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications

    Constantine S. Mitsiades;Steven P. Treon;Nicholas Mitsiades;Yoshihito Shima

  • Biologic sequelae of nuclear factor–κB blockade in multiple myeloma: therapeutic applications

    Nicholas Mitsiades;Constantine S. Mitsiades;Vassiliki Poulaki;Dharminder Chauhan

  • Antimyeloma activity of heat shock protein-90 inhibition.

    Constantine S. Mitsiades;Nicholas S. Mitsiades;Ciaran J. McMullan;Vassiliki Poulaki

  • Retinal Vascular Endothelial Growth Factor Induces Intercellular Adhesion Molecule-1 and Endothelial Nitric Oxide Synthase Expression and Initiates Early Diabetic Retinal Leukocyte Adhesion in Vivo

    Antonia M. Joussen;Antonia M. Joussen;Antonia M. Joussen;Vassiliki Poulaki;Vassiliki Poulaki;Wenying Qin;Wenying Qin;Bernd Kirchhof

  • Molecular sequelae of histone deacetylase inhibition in human malignant B cells

    Nicholas Mitsiades;Constantine S. Mitsiades;Paul G. Richardson;Ciaran McMullan

  • Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity

    Douglas W McMillin;Jake Delmore;Jake Delmore;Ellen Weisberg;Ellen Weisberg;Joseph M Negri;Joseph M Negri

  • Immunomodulatory drug costimulates T cells via the B7-CD28 pathway.

    Richard LeBlanc;Teru Hideshima;Laurence P. Catley;Reshma Shringarpure

  • The Akt pathway: molecular targets for anti-cancer drug development.

    Constantine S. Mitsiades;Nicholas Mitsiades;Michael Koutsilieris

Frequent Co-Authors

Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Nikhil C. Munshi
Nikhil C. Munshi Harvard University
Teru Hideshima
Teru Hideshima Harvard University
Paul G. Richardson
Paul G. Richardson Harvard University
Kenneth C. Anderson
Kenneth C. Anderson Harvard University
Dharminder Chauhan
Dharminder Chauhan Harvard University
Robert L. Schlossman
Robert L. Schlossman Harvard University
Cristian Coarfa
Cristian Coarfa Baylor College of Medicine
Klaus Podar
Klaus Podar Karl Landsteiner University of Health Sciences
Steven P. Treon
Steven P. Treon Harvard University

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