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Irene M. Ghobrial

Irene M. Ghobrial

D-Index & Metrics

Medicine

D-Index
106
Citations
50883
World Ranking
6428
National Ranking
3422

Overview

Irene M. Ghobrial is affiliated with Harvard University in the United States. Their research spans several interconnected fields, focusing primarily on medicine and biochemistry, genetics, and molecular biology. The core areas of study include hematology, molecular biology, oncology, cancer research, and genetics.

The scientist's work addresses various topics, with notable emphasis on multiple myeloma research and treatments, protein degradation and inhibitors, cancer genomics and diagnostics, CAR-T cell therapy research, chronic lymphocytic leukemia research, cancer treatment and pharmacology, and chemokine receptors and signaling.

Recent significant publications by Irene M. Ghobrial include:

  • Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study, 2020, The Lancet Public Health
  • The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee, 2022, Blood
  • Bone marrow niches in haematological malignancies, 2020, Nature Reviews. Cancer
  • Triplet Therapy, Transplantation, and Maintenance until Progression in Myeloma, 2022, New England Journal of Medicine
  • Rapid implementation of mobile technology for real-time epidemiology of COVID-19, 2020, Science

Irene M. Ghobrial frequently collaborates with a range of co-authors, including Gad Getz, Romanos Sklavenitis-Pistofidis, Elizabeth D. Lightbody, Omar Nadeem, and Catherine R. Marinac.

Publications are often found in respected journals and venues related to hematology and oncology. The most frequent publication venues include Blood, Clinical Lymphoma Myeloma & Leukemia, Cancer Research, Journal of Clinical Oncology, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Biological properties of extracellular vesicles and their physiological functions

    María Yáñez-Mó;Pia R.-M. Siljander;Zoraida Andreu;Apolonija Bedina Zavec

  • BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

    Jake E. Delmore;Ghayas C. Issa;Madeleine E. Lemieux;Peter B. Rahl

  • Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study.

    Long H. Nguyen;David A. Drew;Mark S. Graham;Amit D. Joshi

  • Targeting apoptosis pathways in cancer therapy.

    Irene M. Ghobrial;Thomas E. Witzig;Alex A. Adjei

  • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma.

    Paul G. Richardson;Edie Weller;Sagar Lonial;Andrzej J. Jakubowiak

  • Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia

    Steven P. Treon;Christina K. Tripsas;Kirsten Meid;Diane Warren

  • BM mesenchymal stromal cell–derived exosomes facilitate multiple myeloma progression

    Aldo M. Roccaro;Antonio Sacco;Patricia Maiso;Abdel Kareem Azab

  • Phase II Trial of Single-Agent Temsirolimus (CCI-779) for Relapsed Mantle Cell Lymphoma

    Thomas E. Witzig;Susan M. Geyer;Irene Ghobrial;David J. Inwards

  • Mitochondrial metabolism promotes adaptation to proteotoxic stress.

    Peter Tsvetkov;Alexandre Detappe;Kai Cai;Heather R Keys

  • Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.

    Yazan Alsayed;Hai Ngo;Judith Runnels;Xavier Leleu

  • Genomic complexity of multiple myeloma and its clinical implications

    Salomon Manier;Karma Z. Salem;Karma Z. Salem;Jihye Park;Jihye Park;Dan A. Landau

  • CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy

    Abdel Kareem Azab;Judith M. Runnels;Costas Pitsillides;Anne-Sophie Moreau

  • Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma.

    Rao H. Prabhala;Dheeraj Pelluru;Mariateresa Fulciniti;Harsha K. Prabhala

  • MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma.

    Aldo M. Roccaro;Aldo M. Roccaro;Aldo M. Roccaro;Antonio Sacco;Brian Thompson;Xavier Leleu

  • Targeting the bone marrow microenvironment in multiple myeloma

    Yawara Kawano;Michele Moschetta;Salomon Manier;Siobhan Glavey

  • Bone marrow microenvironment in multiple myeloma progression.

    S. Manier;A. Sacco;X. Leleu;Irene Ghobrial

  • A phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma.

    T E Witzig;C B Reeder;Betsy R LaPlant;M Gupta

  • Bone marrow niches in haematological malignancies.

    Simón Méndez-Ferrer;Simón Méndez-Ferrer;Simón Méndez-Ferrer;Dominique Bonnet;David P. Steensma;Robert P. Hasserjian

  • Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

    Abdel Kareem Azab;Jinsong Hu;Phong Quang;Feda Azab

  • Primary Therapy of Waldenström Macroglobulinemia With Bortezomib, Dexamethasone, and Rituximab: WMCTG Clinical Trial 05-180

    Steven P. Treon;Leukothea Ioakimidis;Jacob D. Soumerai;Christopher J. Patterson

Frequent Co-Authors

Paul G. Richardson
Paul G. Richardson Harvard University
Xavier Leleu
Xavier Leleu Harvard University
Steven P. Treon
Steven P. Treon Harvard University
Kenneth C. Anderson
Kenneth C. Anderson Harvard University
Nikhil C. Munshi
Nikhil C. Munshi Harvard University
Robert L. Schlossman
Robert L. Schlossman Harvard University
Teru Hideshima
Teru Hideshima Harvard University
Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Noopur Raje
Noopur Raje Harvard University
Yong Zhang
Yong Zhang Tongji University

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