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Dharminder Chauhan

Dharminder Chauhan

D-Index & Metrics

Medicine

D-Index
123
Citations
54005
World Ranking
3363
National Ranking
1848

Overview

Dharminder Chauhan is a researcher affiliated with Harvard University in the United States. Their work is primarily situated within the fields of Medicine and Biochemistry, Genetics and Molecular Biology, contributing notably to the subfields of Molecular Biology, Hematology, Oncology, Immunology, and Cancer Research.

The primary focus of Chauhan's research revolves around multiple myeloma, including its treatments and underlying molecular and immunological mechanisms. Their main topics of study include:

  • Multiple Myeloma Research and Treatments
  • Ubiquitin and proteasome pathways
  • Peptidase Inhibition and Analysis
  • Protein Degradation and Inhibitors
  • Immunotherapy and Immune Responses
  • Cancer-related molecular mechanisms research
  • Adenosine and Purinergic Signaling

Chauhan has published extensively, with key papers including:

  • "Bortezomib Induces Anti-Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation" (2021, Blood Cancer Discovery)
  • "Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism" (2020, Scientific Reports)
  • "Melflufen plus dexamethasone in relapsed and refractory multiple myeloma (O-12-M1): a multicentre, international, open-label, phase 1-2 study" (2020, The Lancet Haematology)
  • "Preclinical validation of Alpha-Enolase (ENO1) as a novel immunometabolic target in multiple myeloma" (2020, Oncogene)
  • "A 3D-Bioprinted Multiple Myeloma Model" (2021, Advanced Healthcare Materials)

Frequent coauthors who collaborate with Chauhan include Kenneth C. Anderson, Arghya Ray, Ting Du, Nikhil C. Munshi, and Teru Hideshima. Their work has been published repeatedly in several journals, notably:

  • Blood
  • Clinical Lymphoma Myeloma & Leukemia
  • Oncogene
  • Cancer Research
  • Blood Cancer Journal

The body of Chauhan's research contributes primarily to understanding the molecular and immunological bases of multiple myeloma, exploring pathways such as ubiquitin-proteasome systems and protein degradation, and investigating novel therapeutic targets and immunometabolic approaches. Their multidisciplinary approach spans experimental models, clinical studies, and molecular biology techniques relevant to cancer research and hematologic malignancies.

Best Publications

  • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

    Teru Hideshima;Paul Richardson;Dharminder Chauhan;Vito J. Palombella

  • Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy.

    Teru Hideshima;Dharminder Chauhan;Dharminder Chauhan;Yoshihito Shima;Yoshihito Shima;Noopur Raje;Noopur Raje

  • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma.

    Faith E. Davies;Noopur Raje;Noopur Raje;Noopur Raje;Teru Hideshima;Teru Hideshima;Teru Hideshima;Suzanne Lentzsch;Suzanne Lentzsch;Suzanne Lentzsch

  • NF-κB as a Therapeutic Target in Multiple Myeloma *

    Teru Hideshima;Dharminder Chauhan;Paul Richardson;Constantine Mitsiades

  • Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma

    Paul G. Richardson;Robert L. Schlossman;Robert L. Schlossman;Edie Weller;Edie Weller;Teru Hideshima;Teru Hideshima

  • Molecular sequelae of proteasome inhibition in human multiple myeloma cells

    Nicholas Mitsiades;Constantine S. Mitsiades;Vassiliki Poulaki;Dharminder Chauhan

  • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.

    Nicholas Mitsiades;Constantine S. Mitsiades;Paul G. Richardson;Vassiliki Poulaki

  • Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.

    D Gupta;S P Treon;Y Shima;T Hideshima

  • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications

    Nicholas Mitsiades;Constantine S. Mitsiades;Vassiliki Poulaki;Dharminder Chauhan

  • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

    Dharminder Chauhan;Laurence Catley;Guilan Li;Klaus Podar

  • Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

    Constantine S Mitsiades;Nicholas S Mitsiades;Nicholas S Mitsiades;Ciaran J McMullan;Vassiliki Poulaki;Vassiliki Poulaki

  • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341.

    Teru Hideshima;Constantine Mitsiades;Masaharu Akiyama;Toshiaki Hayashi

  • Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma.

    Teru Hideshima;James E. Bradner;Jason Wong;Dharminder Chauhan

  • Human Chromosome 3 Corrects Mismatch Repair Deficiency and Microsatellite Instability and Reduces N-Methyl-N′-nitro-N-nitrosoguanidine Tolerance in Colon Tumor Cells with Homozygous hMLH1 Mutation

    M. Koi;Asad Umar;D. P. Chauhan;S. P. Cherian

  • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B

    Dharminder Chauhan;Hiroshi Uchiyama;Yasmin Akbarali;Mitsuyoshi Urashima

  • Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications

    Constantine S. Mitsiades;Nicholas S. Mitsiades;Ciaran J. McMullan;Vassiliki Poulaki

  • Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

    Teru Hideshima;Laurence Catley;Hiroshi Yasui;Kenji Ishitsuka

  • Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

    Hiroshi Uchiyama;Bruce A. Barut;Ann F. Mohrbacher;Dharminder Chauhan

  • Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.

    Constantine S Mitsiades;Nicholas Mitsiades;Vassiliki Poulaki;Robert Schlossman

  • Small Molecule Inhibition of Proteasome and Aggresome Function Induces Synergistic Anti-Tumor Activity in Multiple Myeloma.

    Teru Hideshima;James E. Bradner;James E. Bradner;Jason Wong;Dharminder Chauhan

Frequent Co-Authors

Teru Hideshima
Teru Hideshima Harvard University
Kenneth C. Anderson
Kenneth C. Anderson Harvard University
Nikhil C. Munshi
Nikhil C. Munshi Harvard University
Paul G. Richardson
Paul G. Richardson Harvard University
Klaus Podar
Klaus Podar Karl Landsteiner University of Health Sciences
Yu-Tzu Tai
Yu-Tzu Tai Harvard University
Noopur Raje
Noopur Raje Harvard University
Constantine S. Mitsiades
Constantine S. Mitsiades Harvard University
Robert L. Schlossman
Robert L. Schlossman Harvard University
Nicholas Mitsiades
Nicholas Mitsiades Baylor College of Medicine

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