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Biology and Biochemistry

D-Index
71
Citations
83166
World Ranking
6480
National Ranking
3016

Overview

Amanda G. Paulovich is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research encompasses multiple areas within biochemistry, genetics, molecular biology, and medicine. Paulovich's work has contributed notably to the fields of molecular biology, spectroscopy, oncology, cancer research, and pulmonary and respiratory medicine.

The scientist's recent publications span high-impact journals and cover a range of cancer-related proteogenomic studies. Key papers include:

  • Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma, 2020, Cell
  • Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy, 2020, Cell
  • A proteogenomic portrait of lung squamous cell carcinoma, 2021, Cell
  • Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer, 2020, Cell
  • Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety, 2022, Cancer Discovery

Frequent co-authors involved in their research include Jeffrey R. Whiteaker, Pei Wang, Jacob J. Kennedy, Richard G. Ivey, and Henry Rodriguez. These collaborations indicate a network focused on cancer biology and proteogenomics.

The primary publication venues for Paulovich's work are:

  • Cell
  • Cancer Research
  • Cancer Cell
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology

Paulovich's research concentrates on several main topics, such as:

  • Advanced Proteomics Techniques and Applications
  • Cancer Genomics and Diagnostics
  • Ferroptosis and cancer prognosis
  • Mass Spectrometry Techniques and Applications
  • RNA modifications and cancer
  • CAR-T cell therapy research
  • Bioinformatics and Genomic Networks

The scientist's body of work contributes extensively to the understanding of cancer biology through proteogenomics and molecular analysis techniques. Their multidisciplinary approach integrates advanced proteomics, genomics, and bioinformatics to investigate therapeutic targets and cancer mechanisms.

Best Publications

  • Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

    Aravind Subramanian;Pablo Tamayo;Vamsi K. Mootha;Sayan Mukherjee

  • Proteogenomics connects somatic mutations to signalling in breast cancer

    Philipp Mertins;D. R. Mani;Kelly V. Ruggles;Michael A. Gillette;Michael A. Gillette

  • Proteogenomic characterization of human colon and rectal cancer

    Bing Zhang;Jing Wang;Xiaojing Wang;Jing Zhu

  • Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

    Terri A. Addona;Susan E. Abbatiello;Birgit Schilling;Steven J. Skates

  • Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

    Hui Zhang;Tao Liu;Zhen Zhang;Samuel H. Payne

  • When Checkpoints Fail

    Amanda G Paulovich;David P Toczyski;Leland H Hartwell;Leland H Hartwell

  • Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

    Michael A. Gillette;Michael A. Gillette;Shankha Satpathy;Song Cao;Saravana M. Dhanasekaran

  • A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

    Amanda G Paulovich;Leland H Hartwell

  • Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma.

    David J. Clark;Saravana M. Dhanasekaran;Francesca Petralia;Jianbo Pan

  • Repeatability and Reproducibility in Proteomic Identifications by Liquid Chromatography−Tandem Mass Spectrometry

    David L. Tabb;Lorenzo Vega-Montoto;Lorenzo Vega-Montoto;Paul A. Rudnick;Asokan Mulayath Variyath;Asokan Mulayath Variyath

  • Proteogenomic and metabolomic characterization of human glioblastoma

    Liang-Bo Wang;Alla Karpova;Marina A. Gritsenko;Jennifer E. Kyle

  • Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.

    Suhas Vasaikar;Chen Huang;Xiaojing Wang;Vladislav A. Petyuk

  • Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach

    Steven A. Carr;Susan E. Abbatiello;Bradley L. Ackermann;Christoph Borchers

  • An Automated and Multiplexed Method for High Throughput Peptide Immunoaffinity Enrichment and Multiple Reaction Monitoring Mass Spectrometry-based Quantification of Protein Biomarkers

    Jeffrey R. Whiteaker;Lei Zhao;Leigh Anderson;Amanda G. Paulovich

  • A targeted proteomics-based pipeline for verification of biomarkers in plasma

    Jeffrey R Whiteaker;Chenwei Lin;Jacob Kennedy;Liming Hou

  • Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function.

    Alexander I. Salter;Richard G. Ivey;Jacob J. Kennedy;Valentin Voillet

  • Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

    Philipp Mertins;Feng Yang;Tao Liu;D. R. Mani

  • Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy.

    Karsten Krug;Eric J. Jaehnig;Shankha Satpathy;Lili Blumenberg

  • Proteogenomic characterization of pancreatic ductal adenocarcinoma

    Liwei Cao;Chen Huang;Daniel Cui Zhou;Yingwei Hu

  • Proteogenomic Characterization of Endometrial Carcinoma.

    Yongchao Dou;Emily A. Kawaler;Daniel Cui Zhou;Marina A. Gritsenko

Frequent Co-Authors

Steven A. Carr
Steven A. Carr Broad Institute
Pei Wang
Pei Wang Icahn School of Medicine at Mount Sinai
Matthew J. Ellis
Matthew J. Ellis Baylor College of Medicine
daniel c liebler
daniel c liebler Vanderbilt University
David Fenyö
David Fenyö New York University
Richard D. Smith
Richard D. Smith Pacific Northwest National Laboratory
Tao Liu
Tao Liu Pacific Northwest National Laboratory
Henry Rodriguez
Henry Rodriguez National Institutes of Health
Bing Zhang
Bing Zhang Baylor College of Medicine
Daniel W. Chan
Daniel W. Chan Johns Hopkins University School of Medicine

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