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Qun-Ying Lei

Qun-Ying Lei

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
23614
World Ranking
12901
National Ranking
403

Overview

Qun-Ying Lei is affiliated with Fudan University in China and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily spans molecular biology, cancer research, oncology, cell biology, and physiology. The scientist's work includes significant exploration of cancer metabolism, epigenetics, RNA modifications, signal transduction pathways, and protein degradation mechanisms.

The main research topics covered in their publications are:

  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • RNA Modifications and Cancer
  • Hippo Pathway Signaling and YAP/TAZ
  • Ubiquitin and Proteasome Pathways
  • Metabolism, Diabetes, and Cancer
  • Histone Deacetylase Inhibitors Research

Some of their notable recent papers include:

  • BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma (2020, Nature Cell Biology)
  • D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1 (2022, Proceedings of the National Academy of Sciences)
  • Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth (2020, Signal Transduction and Targeted Therapy)
  • Par complex cluster formation mediated by phase separation (2020, Nature Communications)
  • Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis (2022, Cell Reports)

Frequent co-authors collaborating with Qun-Ying Lei include:

  • Miao Yin
  • Kun-Liang Guan
  • Weiguo Hu
  • Mingzhu Lei
  • Wenyu Wen

The scientist has published multiple papers in various journals and platforms with a significant number of contributions to the following venues:

  • UNC Libraries
  • Signal Transduction and Targeted Therapy
  • Nature Metabolism
  • Proceedings of the National Academy of Sciences
  • European Urology

Qun-Ying Lei's body of work reflects interdisciplinary research linking molecular biology and cancer mechanisms, with a focus on metabolic pathways, protein modifications, and epigenetic regulation related to cancer development and therapy.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

    Wei Xu;Hui Yang;Ying Liu;Ying Yang

  • Regulation of cellular metabolism by protein lysine acetylation.

    Shimin Zhao;Wei Xu;Wenqing Jiang;Wei Yu

  • The Hippo–YAP pathway in organ size control and tumorigenesis: an updated version

    Bin Zhao;Li Li;Qunying Lei;Kun-Liang Guan

  • Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

    Shimin Zhao;Yan Lin;Wei Xu;Wenqing Jiang

  • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

    Shunyou Wang;Jing Gao;Qunying Lei;Nora Rozengurt

  • TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

    Qun Ying Lei;Heng Zhang;Bin Zhao;Zheng Yu Zha

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.

    Bin Zhao;Li Li;Qing Lu;Lloyd H. Wang

  • TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

    Heng Zhang;Chen Ying Liu;Zheng Yu Zha;Bin Zhao

  • Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

    Lei Lv;Dong Li;Di Zhao;Ruiting Lin

  • The Hippo–YAP pathway: new connections between regulation of organ size and cancer

    Bin Zhao;Qun-Ying Lei;Kun-Liang Guan

  • Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

    Yaohui Chen;Jinye Zhang;Yan Lin;Qunying Lei

  • The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase *

    Chen Ying Liu;Zheng Yu Zha;Xin Zhou;Heng Zhang

  • Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.

    Xue Gao;Shuhai Lin;Shuhai Lin;Feng Ren;Jin Tao Li

  • Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase

    Wenqing Jiang;Shiwen Wang;Mengtao Xiao;Yan Lin

  • Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

    Ruiting Lin;Ren Tao;Xue Gao;Tingting Li

  • Lysine-5 acetylation negatively regulates lactate dehydrogenase a and is decreased in pancreatic cancer

    Di Zhao;Shao Wu Zou;Ying Liu;Xin Zhou

  • Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.

    Lei Lv;Yan Ping Xu;Di Zhao;Fu Long Li

Frequent Co-Authors

Kun-Liang Guan
Kun-Liang Guan Westlake University
Yue Xiong
Yue Xiong University of North Carolina at Chapel Hill
Evelina Gatti
Evelina Gatti Aix-Marseille University
Weiguo Hu
Weiguo Hu Chinese Academy of Sciences
Sagar Lonial
Sagar Lonial Emory University
Sergio Lavandero
Sergio Lavandero University of Chile
Leonidas C. Platanias
Leonidas C. Platanias Northwestern University
Hsing Jien Kung
Hsing Jien Kung Taipei Medical University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Felix Randow
Felix Randow MRC Laboratory of Molecular Biology

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