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Thomas J. Flotte

Thomas J. Flotte

Overview

Thomas J. Flotte is affiliated with the Mayo Clinic in the United States and contributes extensively to research in the fields of medicine and computer science. Their work spans oncology, artificial intelligence, and molecular biology, with a particular focus on the intersection of cancer research and advanced computational methods.

The scientist's research topics include cutaneous melanoma detection and management, AI applications in cancer detection, melanoma and MAPK pathways, CAR-T cell therapy research, generative adversarial networks and image synthesis, immunotherapy and immune responses, and cancer immunotherapy and biomarkers.

Frequent co-authors collaborating with Thomas J. Flotte include Matthew S. Block, Tina J. Hieken, Svetomir N. Markovic, Carrie Strand, and Steven N. Hart.

Publication venues where they have frequently contributed are:

  • Journal of Pathology Informatics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Gastro Hep Advances
  • Annals of Surgical Oncology
  • Journal of Clinical Oncology

Selected recent papers authored or co-authored by Thomas J. Flotte include:

  • Delta-Like Protein 3 Expression and Targeting in Merkel Cell Carcinoma, 2020, The Oncologist
  • Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for high-risk operable Stage III melanoma: the Phase II NeoACTIVATE trial, 2024, Nature Communications
  • Image-to-image translation for automatic ink removal in whole slide images, 2020, Journal of Medical Imaging
  • Dicom_wsi: A Python Implementation for Converting Whole-Slide Images to Digital Imaging and Communications in Medicine Compliant Files, 2021, Journal of Pathology Informatics
  • Resolving the Heterogeneous Tumor-Centric Cellular Neighborhood through Multiplexed, Spatial Paracrine Interactions in the Setting of Immune Checkpoint Blockade, 2022, Cancer Research Communications

Best Publications

  • Optical Coherence Tomography

    David Huang;Eric A. Swanson;Charles P. Lin;Joel S. Schuman

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

    Katherine A. Hoadley;Christina Yau;Christina Yau;Toshinori Hinoue;Denise M. Wolf

  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy

    Alison M. Taylor;Alison M. Taylor;Juliann Shih;Gavin Ha;Gavin Ha;Galen F. Gao

  • Ultraviolet laser-induced fluorescence of colonic tissue: basic biology and diagnostic potential.

    Kevin T. Schomacker;Joan K. Frisoli;Carolyn C. Compton;Thomas J. Flotte

  • Er:YAG laser ablation of tissue: effect of pulse duration and tissue type on thermal damage.

    Joseph T. Walsh;Thomas J. Flotte;Thomas F. Deutsch

  • Erratum: Comprehensive Characterization of Cancer Driver Genes and Mutations (ARTICLE (2018) 173(2) (371–385), (S009286741830237X), (10.1016/j.cell.2018.02.060))

    Matthew H. Bailey;Collin Tokheim;Eduard Porta-Pardo;Sohini Sengupta

  • Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines.

    M E Hemler;F Sanchez-Madrid;T J Flotte;A M Krensky

  • Damage to hair follicles by normal-mode ruby laser pulses

    Melanie C Grossman;Christine Dierickx;William Farinelli;Thomas Flotte

  • Selective photothermolysis of cutaneous pigmentation by Q-switched Nd: YAG laser pulses at 1064, 532, and 355 nm.

    R. Rox Anderson;Randall J. Margolis;Shinichi Watenabe;Thomas Flotte

  • Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.

    Minjung Kim;Joseph D. Gans;Cristina Nogueira;Cristina Nogueira;Audrey Wang

  • Pulsed CO2 laser tissue ablation: Effect of tissue type and pulse duration on thermal damage

    Joseph T. Walsh.;Thomas J. Flotte;R. Rox Anderson;Thomas F. Deutsch

  • Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

    Franz X. Schaub;Varsha Dhankani;Ashton C. Berger;Mihir Trivedi

  • Comparison of responses of tattoos to picosecond and nanosecond Q-switched neodymium: YAG lasers

    E. Victor Ross;E. Victor Ross;George Naseef;Charles Lin;Michael Kelly

  • Photodynamic Therapy of Experimental Choroidal Neovascularization Using Lipoprotein-Delivered Benzoporphyrin

    J W Miller;A W Walsh;M Kramer;T Hasan

  • Expression of murine CD1 on gastrointestinal epithelium.

    Paul A. Bleicher;Steven P. Balk;Steven P. Balk;Susan J. Hagen;Richard S. Blumberg;Richard S. Blumberg

  • Vascular targeting in photodynamic occlusion of subretinal vessels.

    Ursula Schmidt-Erfurth;Ursula Schmidt-Erfurth;Tayyaba Hasan;Evangelos Gragoudas;Norm Michaud

  • Treatment of Tattoos by Q-Switched Ruby Laser: A Dose-Response Study

    C.R. Taylor;R.W. Gange;J.S. Dover;T.J. Flotte

  • Dendritic cell and macrophage staining by monoclonal antibodies in tissue sections and epidermal sheets.

    T J Flotte;T A Springer;G J Thorbecke

  • Confocal scanning laser microscopy of benign and malignant melanocytic skin lesions in vivo.

    Richard G.B. Langley;Milind Rajadhyaksha;Peter J. Dwyer;Arthur J. Sober

  • Microphotocoagulation: selective effects of repetitive short laser pulses

    Johann Roider;Franz Hillenkamp;Thomas Flotte;Reginald Birngruber

Frequent Co-Authors

R. Rox Anderson
R. Rox Anderson Harvard University
Tayyaba Hasan
Tayyaba Hasan Harvard University
Evangelos S. Gragoudas
Evangelos S. Gragoudas Massachusetts Eye and Ear Infirmary
Martin C. Mihm
Martin C. Mihm Brigham and Women's Hospital
Joan W. Miller
Joan W. Miller Massachusetts Eye and Ear Infirmary
Andrew D. Cherniack
Andrew D. Cherniack Broad Institute
Christina Yau
Christina Yau University of California, San Francisco
Maciej Wiznerowicz
Maciej Wiznerowicz Poznan University of Medical Sciences
Houtan Noushmehr
Houtan Noushmehr Henry Ford Health System

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