Biochemistry, Cell biology, Glycolysis, Pyruvate kinase and PKM2 are his primary areas of study. His work carried out in the field of Cell biology brings together such families of science as Cell culture, Cell growth and Metabolic pathway. His Cell growth study incorporates themes from Carcinogenesis, Carbohydrate metabolism and Biosynthesis.
His Glycolysis research incorporates themes from Cancer cell, Signal transduction and Serine. His studies deal with areas such as Enzyme activator, Pyruvate dehydrogenase kinase, Pyruvate dehydrogenase phosphatase, Intracellular and Gene isoform as well as Pyruvate kinase. His work focuses on many connections between PKM2 and other disciplines, such as Phosphorylation, that overlap with his field of interest in Tyrosine kinase.
His scientific interests lie mostly in Biochemistry, Cell biology, Cancer research, Cancer cell and Cancer. All of his Biochemistry and Metabolism, Glutamine, Pyruvate kinase, PKM2 and Glycolysis investigations are sub-components of the entire Biochemistry study. His research investigates the connection between Cell biology and topics such as Cell growth that intersect with issues in Amino acid and Intracellular.
Matthew G. Vander Heiden has researched Cancer research in several fields, including Carcinogenesis, Leukemia, Metastasis and In vivo. His studies in Cancer cell integrate themes in fields like Pancreatic cancer, Serine, Biosynthesis, Enzyme and Extracellular. His Cancer study integrates concerns from other disciplines, such as Pharmacology and Bioinformatics.
His main research concerns Cancer research, Cancer cell, Cell biology, Metabolism and In vivo. The various areas that Matthew G. Vander Heiden examines in his Cancer research study include Cell culture, Cell and Metastasis, Brain metastasis. To a larger extent, Matthew G. Vander Heiden studies Cancer with the aim of understanding Cancer cell.
Matthew G. Vander Heiden combines subjects such as Lipogenesis, Heme binding, ATP synthase and Cell growth with his study of Cell biology. His Metabolism study is associated with Biochemistry. His In vivo research includes themes of Carcinogenesis, Protein kinase B, Neutralizing antibody and p38 mitogen-activated protein kinases.
Matthew G. Vander Heiden spends much of his time researching Cancer research, Cancer cell, In vivo, Cell and Cell type. His work in the fields of Cancer research, such as Stromal cell, intersects with other areas such as Netrin. His Cancer cell study is concerned with the larger field of Cancer.
His biological study spans a wide range of topics, including Branched-chain amino acid, Epigenetics and Metabolic pathway. The study incorporates disciplines such as Immune system, Metabolism and Cell biology in addition to Cell type. His Cell biology study which covers Cancer metabolism that intersects with Tumor microenvironment.
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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden;Lewis C. Cantley;Craig B. Thompson.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang;David W. White;Stefan Gross;Bryson D. Bennett.
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk;Matthew G. Vander Heiden;Marian H. Harris;Arvind Ramanathan.
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Sophia Y. Lunt;Matthew G. Vander Heiden.
Annual Review of Cell and Developmental Biology (2011)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Düvel;Jessica L. Yecies;Suchithra Menon;Pichai Raman.
Molecular Cell (2010)
Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria
Matthew G. Vander Heiden;Navdeep S. Chandel;Edward K. Williamson;Paul T. Schumacker.
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo;Paulo A. Gameiro;Eric L. Bell;Katherine R. Mattaini.
Targeting cancer metabolism: a therapeutic window opens
Matthew G. Vander Heiden;Matthew G. Vander Heiden.
Nature Reviews Drug Discovery (2011)
Understanding the Intersections between Metabolism and Cancer Biology
Matthew G. Vander Heiden;Matthew G. Vander Heiden;Ralph J. DeBerardinis.
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Cosimo Commisso;Shawn M. Davidson;Rengin G. Soydaner-Azeloglu;Seth J. Parker.
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