Matthew G. Vander Heiden

Overview

Best Publications

• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  Matthew G. Vander Heiden;Lewis C. Cantley;Craig B. Thompson

  16441
  Citations

• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  6452
  Citations

• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

  Lenny Dang;David W. White;Stefan Gross;Bryson D. Bennett

  4456
  Citations

• The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

  Heather R. Christofk;Matthew G. Vander Heiden;Marian H. Harris;Arvind Ramanathan

  3183
  Citations

• Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

  Sophia Y. Lunt;Matthew G. Vander Heiden

  3071
  Citations

• Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

  Katrin Düvel;Jessica L. Yecies;Suchithra Menon;Pichai Raman

  2171
  Citations

• Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

  Christian M. Metallo;Paulo A. Gameiro;Eric L. Bell;Katherine R. Mattaini

  2046
  Citations

• Understanding the Intersections between Metabolism and Cancer Biology

  Matthew G. Vander Heiden;Matthew G. Vander Heiden;Ralph J. DeBerardinis

  1875
  Citations

• Targeting cancer metabolism: a therapeutic window opens

  Matthew G. Vander Heiden;Matthew G. Vander Heiden

  1864
  Citations

• Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

  Matthew G. Vander Heiden;Navdeep S. Chandel;Edward K. Williamson;Paul T. Schumacker

  1750
  Citations

• Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

  Cosimo Commisso;Shawn M. Davidson;Rengin G. Soydaner-Azeloglu;Seth J. Parker

  1614
  Citations

• Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

  Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis

  1241
  Citations

• Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

  Dimitrios Anastasiou;Dimitrios Anastasiou;George Poulogiannis;George Poulogiannis;John M. Asara;John M. Asara;Matthew B. Boxer

  1227
  Citations

• Pyruvate kinase M2 is a phosphotyrosine-binding protein

  Heather R. Christofk;Matthew G. Vander Heiden;Ning Wu;John M. Asara;John M. Asara

  1173
  Citations

• Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

  Eva M. Palsson-McDermott;Anne M. Curtis;Gautam Goel;Gautam Goel;Mario A.R. Lauterbach

  1135
  Citations

• Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

  Lucas B. Sullivan;Dan Y. Gui;Aaron M. Hosios;Lauren N. Bush

  1070
  Citations

• Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?

  Vander Heiden Mg;Thompson Cb

  944
  Citations

• Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

  Taro Hitosugi;Sumin Kang;Matthew G. Vander Heiden;Tae Wook Chung

  855
  Citations

• Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

  Matthew G. Vander Heiden;Dimitrios Anastasiou;George Poulogiannis;John M. Asara

  3
  Citations

• Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

  J. Locasale;J. Locasale;Alexandra Grassian;Rameen Beroukhim;Matthew Langer Meyerson

  2
  Citations